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Application of Tissue Engineering and Regenerative Medicine in Prelabor Rupture of Membranes: a Review of the Current Evidence

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Abstract

Preterm prelabor rupture of membranes (PPROM) is the main cause of preterm delivery, resulting in increased perinatal morbidity and mortality. Several techniques have been studied for the healing of ruptured membranes, with some success. Before new techniques using tissue/organ engineering are applied in clinical practice, these techniques must be validated in clinical trials. To address this issue, the objective of this study was to summarize the current literature on interventions to seal or heal the amniotic membranes after PPROM. An electronic search was conducted using the keywords “fetal membranes,” “premature rupture,” “amnion,” “tissue engineering,” “fibrin tissue adhesive,” “regenerative medicine,” “tissue adhesive,” “wound healing,” and “fetoscopy” through the MEDLINE, Embase, and Cochrane CENTRAL databases, with the limitation of English-language studies. Through a review of the identified studies, it was found that spontaneous healing of the fetal membrane has not been successful. Several efforts have been made to seal membranes before or after rupture using different methods, including amniopatches, collagen, tissue patches, fibrin sealant, mussel-mimetic sealant, engineered cell matrix, and immunological supplements. However, most studies have been conducted in ex vivo or in vivo settings, so the safety and applicability of these techniques to spontaneous rupture of membranes in clinical settings have not been sufficiently tested. Overall, the current evidence is limited regarding the safety and effectiveness of interventions against PPROM.

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References

  1. Mercer BM. Preterm premature rupture of the membranes. J Obstet Gynecol. 2003;101(1):178–93.

    Google Scholar 

  2. Beydoun SN, Yasin SY. Premature Rupture of the Membranes before 28 Weeks - Conservative Management. Am J Obstet Gynecol. 1986;155(3):471–9. https://doi.org/10.1016/0002-9378(86)90257-7.

    Article  CAS  PubMed  Google Scholar 

  3. Bengtson JM, Vanmarter LJ, Barss VA, Greene MF, Tuomala RE, Epstein MF. Pregnancy Outcome after Premature Rupture of the Membranes at or before 26 Weeks Gestation. Obstet Gynecol. 1989;73(6):921–7.

    CAS  PubMed  Google Scholar 

  4. Waters TP, Mercer B. Preterm PROM: prediction, prevention, principles. Clin Obstet Gynecol. 2011;54(2):307–12. https://doi.org/10.1097/GRF.0b013e318217d4d3.

    Article  PubMed  Google Scholar 

  5. Gomez R, Romero R, Edwin SS, David C. Pathogenesis of preterm labor and preterm premature rupture of membranes associated with intraamniotic infection. Infect Dis Clin N Am. 1997;11(1):135–76. https://doi.org/10.1016/s0891-5520(05)70347-0.

    Article  CAS  Google Scholar 

  6. Dutta EH, Behnia F, Boldogh I, Saade GR, Taylor BD, Kacerovsky M, et al. Oxidative stress damage-associated molecular signaling pathways differentiate spontaneous preterm birth and preterm premature rupture of the membranes. Mol Hum Reprod. 2016;22(2):143–57. https://doi.org/10.1093/molehr/gav074.

    Article  CAS  PubMed  Google Scholar 

  7. Berkowitz GS, Blackmore-Prince C, Lapinski RH, Savitz DA. Risk factors for preterm birth subtypes. Epidemiology. 1998;9(3):279–85.

    Article  CAS  Google Scholar 

  8. Harger JH, Hsing AW, Tuomala RE, Gibbs RS, Mead PB, Eschenbach DA, et al. Risk factors for preterm premature rupture of fetal membranes: a multicenter case-control study. Am J Obstet Gynecol. 1990;163(1 Pt 1):130–7. https://doi.org/10.1016/s0002-9378(11)90686-3.

    Article  CAS  PubMed  Google Scholar 

  9. Ramsey PS, Lieman JM, Brumfield CG, Carlo W. Chorioamnionitis increases neonatal morbidity in pregnancies complicated by preterm premature rupture of membranes. Am J Obstet Gynecol. 2005;192(4):1162–6. https://doi.org/10.1016/j.ajog.2004.11.035.

    Article  PubMed  Google Scholar 

  10. Thibeault DW, Beatty EC Jr, Hall RT, Bowen SK, O'Neill DH. Neonatal pulmonary hypoplasia with premature rupture of fetal membranes and oligohydramnios. J Pediatr. 1985;107(2):273–7. https://doi.org/10.1016/s0022-3476(85)80148-7.

    Article  CAS  PubMed  Google Scholar 

  11. Bryant-Greenwood GD. The extracellular matrix of the human fetal membranes: structure and function. Placenta. 1998;19(1):1–11. https://doi.org/10.1016/s0143-4004(98)90092-3.

    Article  CAS  PubMed  Google Scholar 

  12. Gratacos E, Sanin-Blair J, Lewi L, Toran N, Verbist G, Cabero L, et al. A histological study of fetoscopic membrane defects to document membrane healing. Placenta. 2006;27(4-5):452–6. https://doi.org/10.1016/j.placenta.2005.03.008.

    Article  CAS  PubMed  Google Scholar 

  13. McLaren J, Taylor DJ, Bell SC. Increased incidence of apoptosis in non-labour-affected cytotrophoblast cells in term fetal membranes overlying the cervix. Hum Reprod. 1999;14(11):2895–900. https://doi.org/10.1093/humrep/14.11.2895.

    Article  CAS  PubMed  Google Scholar 

  14. Borgida AF, Mills AA, Feldman DM, Rodis JF, Egan JF. Outcome of pregnancies complicated by ruptured membranes after genetic amniocentesis. Am J Obstet Gynecol. 2000;183(4):937–9. https://doi.org/10.1067/mob.2000.108872.

    Article  CAS  PubMed  Google Scholar 

  15. Johnson JWC, Egerman RS, Moorhead J. Cases with Ruptured Membranes That Reseal. Am J Obstet Gynecol. 1990;163(3):1024–32.

    Article  CAS  Google Scholar 

  16. Thomson AJ. Royal Coll Obstetricians. Care of Women Presenting with Suspected Preterm Prelabour Rupture of Membranes from 24(+0) Weeks of Gestation Green-top Guideline No. 73. BJOG: An International Journal of Obstetrics and Gynaecology. 2019;126(9):E152–E65. https://doi.org/10.1111/1471-0528.15803.

    Article  CAS  Google Scholar 

  17. Quintero RA, Morales WJ, Allen M, Bornick PW, Arroyo J, LeParc G. Treatment of iatrogenic previable premature rupture of membranes with intra-amniotic injection of platelets and cryoprecipitate (amniopatch): preliminary experience. Am J Obstet Gynecol. 1999;181(3):744–9. https://doi.org/10.1016/s0002-9378(99)70522-3.

    Article  CAS  PubMed  Google Scholar 

  18. Deprest J, Emonds MP, Richter J, DeKoninck P, Van Mieghem T, Van Schoubroeck D, et al. Amniopatch for iatrogenic rupture of the fetal membranes. Prenat Diagn. 2011;31(7):661–6. https://doi.org/10.1002/pd.2780.

    Article  PubMed  Google Scholar 

  19. Papadopulos NA, Klotz S, Raith A, Foehn M, Schillinger U, Henke J, et al. Amnion cells engineering: a new perspective in fetal membrane healing after intrauterine surgery? Fetal Diagn Ther. 2006;21(6):494–500. https://doi.org/10.1159/000095660.

    Article  PubMed  Google Scholar 

  20. Papadopulos NA, Kyriakidis DI, Schillinger U, Totis A, Henke J, Kovacs L, et al. Successful anatomic repair of fetoscopic access sites in the mid-gestational rabbit model using amnion cell engineering. In Vivo. 2010;24(5):745–50.

    PubMed  Google Scholar 

  21. Gratacos E, Wu J, Yesildaglar N, Devlieger R, Pijnenborg R, Deprest JA. Successful sealing of fetoscopic access sites with collagen plugs in the rabbit model. Am J Obstet Gynecol. 2000;182(1 Pt 1):142–6. https://doi.org/10.1016/s0002-9378(00)70503-5.

    Article  CAS  PubMed  Google Scholar 

  22. Baumgarten K, Moser S. The technique of fibrin adhesion for premature rupture of the membranes during pregnancy. J Perinat Med. 1986;14(1):43–9. https://doi.org/10.1515/jpme.1986.14.1.43.

    Article  CAS  PubMed  Google Scholar 

  23. Uchide K, Terada S, Hamasaki H, Suzuki N, Akasofu K. Intracervical fibrin instillation as an adjuvant to treatment for second trimester rupture of membranes. Arch Gynecol Obstet. 1994;255(2):95–8. https://doi.org/10.1007/BF02391804.

    Article  CAS  PubMed  Google Scholar 

  24. Gibble JW, Ness PM. Fibrin glue: the perfect operative sealant? Transfusion. 1990;30(8):741–7. https://doi.org/10.1046/j.1537-2995.1990.30891020337.x.

    Article  CAS  PubMed  Google Scholar 

  25. Sciscione AC, Manley JS, Pollock M, Maas B, Shlossman PA, Mulla W, et al. Intracervical fibrin sealants: a potential treatment for early preterm premature rupture of the membranes. Am J Obstet Gynecol. 2001;184(3):368–73. https://doi.org/10.1067/mob.2001.111796.

    Article  CAS  PubMed  Google Scholar 

  26. Harmanli OH, Wapner RJ, Lontz JF. Efficacy of fibrin glue for in vitro sealing of human chorioamniotic membranes. J Reprod Med. 1998;43(11):986–90.

    CAS  PubMed  Google Scholar 

  27. Young BK, Roque H, Abdelhak YE, Poiolek D, Demopulos R, Lockwood CJ. Minimally invasive endoscopy in the treatment of preterm premature rupture of membranes by application of fibrin sealant. J Perinat Med. 2000;28(4):326–30. https://doi.org/10.1515/JPM.2000.042.

    Article  CAS  PubMed  Google Scholar 

  28. Reddy UM, Shah SS, Nemiroff RL, Ballas SK, Hyslop T, Chen J, et al. In vitro sealing of punctured fetal membranes: potential treatment for midtrimester premature rupture of membranes. Am J Obstet Gynecol. 2001;185(5):1090–3. https://doi.org/10.1067/mob.2001.117685.

    Article  CAS  PubMed  Google Scholar 

  29. Calado E, Ayres-de-Campos D. Premature rupture of membranes at 20 weeks: report of a successful outcome after transcervical application of fibrin glue. Fetal Diagn Ther. 2007;22(1):14–7. https://doi.org/10.1159/000095836.

    Article  PubMed  Google Scholar 

  30. Bilic G, Brubaker C, Messersmith PB, Mallik AS, Quinn TM, Haller C, et al. Injectable candidate sealants for fetal membrane repair: bonding and toxicity in vitro. Am J Obstet Gynecol. 2010;202(1):85 e1–9. https://doi.org/10.1016/j.ajog.2009.07.051.

    Article  CAS  Google Scholar 

  31. Haller CM, Buerzle W, Brubaker CE, Messersmith PB, Mazza E, Ochsenbein-Koelble N, et al. Mussel-mimetic tissue adhesive for fetal membrane repair: a standardized ex vivo evaluation using elastomeric membranes. Prenat Diagn. 2011;31(7):654–60. https://doi.org/10.1002/pd.2712.

    Article  CAS  PubMed  Google Scholar 

  32. Haller CM, Buerzle W, Kivelio A, Perrini M, Brubaker CE, Gubeli RJ, et al. Mussel-mimetic tissue adhesive for fetal membrane repair: an ex vivo evaluation. Acta Biomater. 2012;8(12):4365–70. https://doi.org/10.1016/j.actbio.2012.07.047.

    Article  CAS  PubMed  Google Scholar 

  33. Kivelio A, Dekoninck P, Perrini M, Brubaker CE, Messersmith PB, Mazza E, et al. Mussel mimetic tissue adhesive for fetal membrane repair: initial in vivo investigation in rabbits. Eur J Obstet Gynecol Reprod Biol. 2013;171(2):240–5. https://doi.org/10.1016/j.ejogrb.2013.09.003.

    Article  CAS  PubMed  Google Scholar 

  34. Dam P, Laha S, Bhattacharya P, Daga P. Role of amnioseal in premature rupture of membranes. J Obstet Gynaecol India. 2011;61(3):296–300.

    Article  CAS  Google Scholar 

  35. Pensabene V, Patel PP, Williams P, Cooper TL, Kirkbride KC, Giorgio TD, et al. Repairing Fetal Membranes with a Self-adhesive Ultrathin Polymeric Film: Evaluation in Mid-gestational Rabbit Model. Ann Biomed Eng. 2015;43(8):1978–88. https://doi.org/10.1007/s10439-014-1228-9.

    Article  PubMed  Google Scholar 

  36. Vaitkiene D, Bergstrom S. Management of Amniocentesis in Women with Oligohydramnios Due to Membrane Rupture - Evaluation of a Cervical Adapter. Gynecol Obstet Investig. 1995;40(1):28–31. https://doi.org/10.1159/000292297.

    Article  CAS  Google Scholar 

  37. Luks FI, Deprest JA, Peers KH, Steegers EA, van Der Wildt B. Gelatin sponge plug to seal fetoscopy port sites: technique in ovine and primate models. Am J Obstet Gynecol. 1999;181(4):995–6. https://doi.org/10.1016/s0002-9378(99)70338-8.

    Article  CAS  PubMed  Google Scholar 

  38. O'Brien JM, Milligan DA, Barton JR. Gelatin sponge embolization. a method for the management of iatrogenic preterm premature rupture of the membranes. Fetal Diagn Ther. 2002;17(1):8–10. https://doi.org/10.1159/000047997.

    Article  PubMed  Google Scholar 

  39. Papadopulos NA, Van Ballaer PP, Ordonez JL, Laermans IJ, Vandenberghe K, Lerut TE, et al. Fetal membrane closure techniques after hysteroamniotomy in the midgestational rabbit model. Am J Obstet Gynecol. 1998;178(5):938–42. https://doi.org/10.1016/s0002-9378(98)70527-7.

    Article  CAS  PubMed  Google Scholar 

  40. Quintero RA, Morales WJ, Bornick PW, Allen M, Garabelis N. Surgical treatment of spontaneous rupture of membranes: the amniograft--first experience. Am J Obstet Gynecol. 2002;186(1):155–7. https://doi.org/10.1067/mob.2002.119185.

    Article  PubMed  Google Scholar 

  41. Mendoza GA, Acuna E, Allen M, Arroyo J, Quintero RA. In vitro laser welding of amniotic membranes. Lasers Surg Med. 1999;24(5):315–8. https://doi.org/10.1002/(sici)1096-9101(1999)24:5<315::aid-lsm1>3.0.co;2-1.

    Article  CAS  PubMed  Google Scholar 

  42. Quintero RA, Mendoza GA, Allen M, Arroyo J, Bornick PW, Morales WJ, et al. In vivo laser welding of collagen-based graft material to the amnion in a rabbit model of ruptured membranes. Prenatal Neonatal Med. 1999;4(6):453–6.

    Google Scholar 

  43. Carnaghan HK, Harrison MR. Presealing of the chorioamniotic membranes prior to fetoscopic surgery: preliminary study with unfertilized chicken egg models. Eur J Obstet Gynecol Reprod Biol. 2009;144(Suppl 1):S142–5. https://doi.org/10.1016/j.ejogrb.2009.02.026.

    Article  PubMed  Google Scholar 

  44. Engels AC, Van Calster B, Richter J, DeKoninck P, Lewi L, De Catte L, et al. Collagen plug sealing of iatrogenic fetal membrane defects after fetoscopic surgery for congenital diaphragmatic hernia. Ultrasound Obstet Gynecol. 2014;43(1):54–9. https://doi.org/10.1002/uog.12547.

    Article  CAS  PubMed  Google Scholar 

  45. Snowise S, Mann LK, Moise KJ Jr, Johnson A, Bebbington MW, Papanna R. Preterm prelabor rupture of membranes after fetoscopic laser surgery for twin-twin transfusion syndrome. Ultrasound Obstet Gynecol. 2017;49(5):607–11. https://doi.org/10.1002/uog.15958.

    Article  CAS  PubMed  Google Scholar 

  46. Devaud YR, Zuger S, Zimmermann R, Ehrbar M, Ochsenbein-Kolble N. Minimally Invasive Surgical Device for Precise Application of Bioadhesives to Prevent iPPROM. Fetal Diagn Ther. 2019;45(2):102–10. https://doi.org/10.1159/000487393.

    Article  PubMed  Google Scholar 

  47. Petratos PB, Baergen RN, Bleustein CB, Felsen D, Poppas DP. Ex vivo evaluation of human fetal membrane closure. Lasers Surg Med. 2002;30(1):48–53. https://doi.org/10.1002/lsm.1140.

    Article  PubMed  Google Scholar 

  48. Devlieger R, Ardon H, Verbist L, Gratacos E, Pijnenborg R, Deprest JA. Increased polymorphonuclear infiltration and iatrogenic amniotic band after closure of fetoscopic access sites with a bioactive membrane in the rabbit at midgestation. Am J Obstet Gynecol. 2003;188(3):844–8. https://doi.org/10.1067/mob.2003.213.

    Article  PubMed  Google Scholar 

  49. Young BK, Mackenzie AP, Roman AS, Stephenson CD, Minior V, Rebarber A, et al. Endoscopic closure of fetal membrane defects: comparing iatrogenic versus spontaneous rupture cases. J Matern Fetal Neonatal Med. 2004;16(4):235–40. https://doi.org/10.1080/14767050400014774.

    Article  CAS  PubMed  Google Scholar 

  50. Rouzaire M, Comptour A, Belville C, Bouvier D, Clairefonda G, Ponelle F, et al. All-trans retinoic acid promotes wound healing of primary amniocytes through the induction of LOXL4, a member of the lysyl oxidase family. Int J Biochem Cell B. 2016;81:10–9. https://doi.org/10.1016/j.biocel.2016.10.007.

    Article  CAS  Google Scholar 

  51. Quintero RA, Romero R, Dzieczkowski J, Mammen E, Evans MI. Sealing of ruptured amniotic membranes with intra-amniotic platelet-cryoprecipitate plug. Lancet. 1996;347(9008):1117. https://doi.org/10.1016/s0140-6736(96)90316-5.

    Article  CAS  PubMed  Google Scholar 

  52. Deprest JA, Papadopulos NA, Decaluw H, Yamamoto H, Lerut TE, Gratacos E. Closure techniques for fetoscopic access sites in the rabbit at mid-gestation. Hum Reprod. 1999;14(7):1730–4. https://doi.org/10.1093/humrep/14.7.1730.

    Article  CAS  PubMed  Google Scholar 

  53. Quintero RA. New horizons in the treatment of preterm premature rupture of membranes. Clin Perinatol. 2001;28(4):861–75. https://doi.org/10.1016/s0095-5108(03)00083-6.

    Article  CAS  PubMed  Google Scholar 

  54. Devlieger R, Riley SC, Verbist L, Leask R, Pijnenborg R, Deprest JA. Matrix metalloproteinases-2 and-9 and their endogenous tissue inhibitors in tissue remodeling after sealing of the fetal membranes in a sheep model of fetoscopic surgery. J Soc Gynecol Investig. 2002;9(3):137–45. https://doi.org/10.1016/S1071-5576(02)00142-9.

    Article  CAS  PubMed  Google Scholar 

  55. Lewi L, Van Schoubroeck D, Van Ranst M, Bries G, Emonds MP, Arabin B, et al. Successful patching of iatrogenic rupture of the fetal membranes. Placenta. 2004;25(4):352–6. https://doi.org/10.1016/j.placenta.2003.09.003.

    Article  CAS  PubMed  Google Scholar 

  56. Cobo T, Borrell A, Fortuny A, Hernandez S, Perez M, Palacio M, et al. Treatment with amniopatch of premature rupture of membranes after first-trimester chorionic villus sampling. Prenat Diagn. 2007;27(11):1024–7. https://doi.org/10.1002/pd.1825.

    Article  PubMed  Google Scholar 

  57. Mallik AS, Fichter MA, Rieder S, Bilic G, Stergioula S, Henke J, et al. Fetoscopic closure of punctured fetal membranes with acellular human amnion plugs in a rabbit model. Obstet Gynecol. 2007;110(5):1121–9. https://doi.org/10.1097/01.AOG.0000284624.23598.7c.

    Article  PubMed  Google Scholar 

  58. Ochsenbein-Kolble N, Jani J, Lewi L, Verbist G, Vercruysse L, Portmann-Lanz B, et al. Enhancing sealing of fetal membrane defects using tissue engineered native amniotic scaffolds in the rabbit model. Am J Obstet Gynecol. 2007;196(3):263 e1–7. https://doi.org/10.1016/j.ajog.2006.10.904.

    Article  Google Scholar 

  59. Mandelbrot L, Bourguignat L, Mellouhi IS, Gavard L, Morin F, Bierling P. Treatment by autologous amniopatch of premature rupture of membranes following mid-trimester amniocentesis. Ultrasound Obstet Gynecol. 2009;33(2):245–6. https://doi.org/10.1002/uog.6243.

    Article  CAS  PubMed  Google Scholar 

  60. Chmait RH, Kontopoulos EV, Chon AH, Korst LM, Llanes A, Quintero RA. Amniopatch treatment of iatrogenic preterm premature rupture of membranes (iPPROM) after fetoscopic laser surgery for twin-twin transfusion syndrome. J Matern Fetal Neonatal Med. 2017;30(11):1349–54. https://doi.org/10.1080/14767058.2016.1214123.

    Article  PubMed  Google Scholar 

  61. Engels AC, Joyeux L, Van der Merwe J, Jimenez J, Pranpanus S, Barrett DW, et al. Tissuepatch is biocompatible and seals iatrogenic membrane defects in a rabbit model. Prenat Diagn. 2018;38(2):99–105. https://doi.org/10.1002/pd.5191.

    Article  CAS  PubMed  Google Scholar 

  62. O'Brien JM, Barton JR, Milligan DA. An aggressive interventional protocol for early midtrimester premature rupture of the membranes using gelatin sponge for cervical plugging. Am J Obstet Gynecol. 2002;187(5):1143–6. https://doi.org/10.1067/mob.2002.127124.

    Article  PubMed  Google Scholar 

  63. Maged AM, Kamel HH, Sanad AS, Mahram AE, AbdAllah AA, Elkhateeb R, et al. The value of amniopatch in pregnancies associated with spontaneous preterm premature rupture of fetal membranes: a randomized controlled trial. J Matern Fetal Neonatal Med. 2019;34:1–7. https://doi.org/10.1080/14767058.2019.1605348.

    Article  CAS  Google Scholar 

  64. Engels AC, Hoylaerts MF, Endo M, Loyen S, Verbist G, Manodoro S, et al. In vitro sealing of iatrogenic fetal membrane defects by a collagen plug imbued with fibrinogen and plasma. Prenat Diagn. 2013;33(2):162–7. https://doi.org/10.1002/pd.4032.

    Article  CAS  PubMed  Google Scholar 

  65. Louis-Sylvestre C, Rand JH, Gordon RE, Salafia CM, Berkowitz RL. In vitro studies of the interactions between platelets and amniotic membranes: A potential treatment for preterm premature rupture of the membranes. Am J Obstet Gynecol. 1998;178(2):287–93. https://doi.org/10.1016/S0002-9378(98)80014-8.

    Article  CAS  PubMed  Google Scholar 

  66. Devlieger R, Riley SC, Verbist L, Leask R, Pijnenborg R, Deprest JA. Matrix metalloproteinases-2 and -9 and their endogenous tissue inhibitors in tissue remodeling after sealing of the fetal membranes in a sheep model of fetoscopic surgery. J Soc Gynecol Investig. 2002;9(3):137–45.

    Article  CAS  Google Scholar 

  67. Young BK, Roman AS, MacKenzie AP, Stephenson CD, Minior V, Rebarber A, et al. The closure of iatrogenic membrane defects after amniocentesis and endoscopic intrauterine procedures. Fetal Diagn Ther. 2004;19(3):296–300. https://doi.org/10.1159/000076715.

    Article  PubMed  Google Scholar 

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Acknowledgements

We thank Eun-Sun Park at Seoul National University Medical library for her contribution to developing the search strategy in the MEDLINE database via Ovid.

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  1. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Korea

    Young Mi Jung, Chan-Wook Park, Joong Shin Park, Jong Kwan Jun & Seung Mi Lee

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YMJ and SML performed the literature search and collected data. SML, CWP, and JSP made substantial contribution to the conception of the study. YMJ and JKJ contributed to the study design and interpretation of included research studies. The final version of the manuscript has been read and approved by all authors.

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Jung, Y.M., Park, CW., Park, J.S. et al. Application of Tissue Engineering and Regenerative Medicine in Prelabor Rupture of Membranes: a Review of the Current Evidence. Reprod. Sci. 28, 1774–1784 (2021). https://doi.org/10.1007/s43032-021-00525-2

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