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Genomic evolution of bovine viral diarrhea virus based on complete genome and individual gene analyses

  • Veterinary Microbiology - Research Paper
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Abstract

Bovine viral diarrhea virus (BVDV) genome consists of a single-stranded, positive-sense RNA with high genetic diversity. In the last years, significant progress has been achieved in BVDV knowledge evolution through phylodynamic analysis based on the partial 5′UTR sequences, whereas a few studies have used other genes or the complete coding sequence (CDS). However, no research has evaluated and compared BVDV evolutionary history based on the complete genome (CG), CDS, and individual genes. In this study, phylodynamic analyses were carried out with BVDV-1 (Pestivirus A) and BVDV-2 (Pestivirus B) CG sequences available on the GenBank database and each genomic region: CDS, UTRs, and individual genes. In comparison to the CG, the estimations for both BVDV species varied according to the dataset used, pointing out the importance of considering the analyzed genomic region when concluding. This study may provide new insight into BVDV evolution history while highlighting the need to increase the available BVDV CG sequences to perform more comprehensive phylodynamic studies in the future.

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Acknowledgements

We acknowledge researchers who laboriously collected and analyzed the bovine viral diarrhea virus sequences published and available in the GenBank database.

Author information

Authors and Affiliations

  1. Centro de Investigación Veterinaria de Tandil (CIVETAN) CONICET-CICPBA-UNCPBA, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Paraje Arroyo Seco S/N, Campus Universitario, 7000, Tandil, CP, Argentina

    Maximiliano J. Spetter

  2. Laboratorio de Virología Veterinaria, Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible (IPADS, INTA-CONICET), Ruta 226 km 73.5, 7620, Balcarce Buenos Aires, CP, Argentina

    Enrique L. Louge Uriarte, Andrea E. Verna & Erika A. González Altamiranda

  3. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Godoy Cruz 2290, C1033AAJ, Buenos Aires, Argentina

    Andrea E. Verna & Erika A. González Altamiranda

  4. Facultad de Ciencias Agrarias, Universidad Nacional de Mar del Plata, Ruta 226 km 73.5, 7620, Buenos Aires, CP, Argentina

    Anselmo C. Odeón

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  1. Maximiliano J. Spetter
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  5. Erika A. González Altamiranda
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Contributions

All authors contributed to the study conception and design. Maximiliano J. Spetter, Enrique L. Louge Uriarte, and Erika A. González Altamiranda performed material preparation, data collection, and analysis. Maximiliano J. Spetter wrote the first draft of the manuscript, and all authors commented on previous versions. All authors read and approved the final version of the manuscript.

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Correspondence to Erika A. González Altamiranda.

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Spetter, M.J., Louge Uriarte, E.L., Verna, A.E. et al. Genomic evolution of bovine viral diarrhea virus based on complete genome and individual gene analyses. Braz J Microbiol 54, 2461–2469 (2023). https://doi.org/10.1007/s42770-023-00986-4

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