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One Pot and Two Pot Synthetic Strategies and Biological Applications of Epoxy-Chalcones

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Abstract

Epoxy chalcone is a heterocyclic molecule and an important precursor for the synthesis of biologically active compounds. This mini-review is elucidating the synthetic strategies of chalcone epoxide via one pot and two pot routes including nature of reactants, nature of catalyst and variety of catalyst to improve yield of desired product, biological applications and advantages and drawbacks of these synthetic strategies. One pot route has wide variety of reactants and efficient one is the condensation of aldehyde and ketone. However, two pot route is consisted of chalcone synthesis preceding to epoxy chalcone. The synthetic routes for the preparation of epoxy chalcone and the usage as a precursor for the synthesis of various organic molecules with biological application is comprehensively discussed. This review is outstanding in organic chemistry and pharmaceutical industries to produce new molecules with various applications.

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Acknowledgements

The authors would like to thank to Minister of Higher Education Malaysia and Postgraduate Research Grant, Universiti Malaysia Sarawak for financial support.

Funding

This work was supported by Minister of Higher Education through F07/FRGS/1883/2019 and Universiti Malaysia Sarawak through F07/PGRS/1794/2019.

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  1. Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300, Kota Samarahan, Sarawak, Malaysia

    Saba Farooq & Zainab Ngaini

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  2. Zainab Ngaini
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Farooq, S., Ngaini, Z. One Pot and Two Pot Synthetic Strategies and Biological Applications of Epoxy-Chalcones. Chemistry Africa 3, 291–302 (2020). https://doi.org/10.1007/s42250-020-00128-5

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