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The relationship between primary sarcopenia and SARC-F, serum MMP9, TIMP1 levels, and MMP9/TIMP1 ratio in the geriatric patients

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Key summary points

AbstractSection Aim

The aim of this study was to determine the relationship between primary sarcopenia and SARC-F score, serum MMP9 (Matrix metalloproteinase), TIMP1 (Tissue inhibitor of metalloproteinase) levels, and MMP9/TIMP1 ratio in the geriatric patients.

AbstractSection Finding

The SARC-F and MMP9/TIMP1 ratio showed significant and similar diagnostic accuracy for sarcopenia.

AbstractSection Message

The ability of SARC-F to screen similarly to more objective biomarkers such as the MMP9 / TIMP1 ratio for sarcopenia supports the use of the SARC-F questionnaire in daily practice.

Abstract

Purpose

The purpose of this study is to evaluate the relationship between serum MMP9 (Matrix metalloproteinase), TIMP1 (Tissue inhibitor of metalloproteinase) levels and MMP9/TIMP1 ratio and primary sarcopenia in geriatric patients, and compare the diagnostic accuracy of such biomarkers with that of the SARC-F score.

Methods

A total of 88 patients aged 65 years and older were assessed in the study. Comorbidities and geriatric syndromes were determined and patients with secondary sarcopenia were excluded. EWGSOP2 criteria were used as diagnostic criteria for sarcopenia and SARC-F questionnaire was used to find individuals at risk for sarcopenia. Serum MMP9 and TIMP1 levels were analyzed by ELISA method.

Results

SARC-F, serum MMP9 and MMP9/TIMP1 ratio were significantly higher in the group with sarcopenia compared to the group without sarcopenia (p = 0.001, p = 0.026 and p = 0.006, respectively). In univariate logistic regression analysis, while SARC-F score and MMP9/TIMP1 ratio were significant, MMP9, TIMP1, age and gender were not. In the multivariate logistic regression analysis of the SARC-F score and the MMP9/TIMP1 ratio, it was determined that both of them were associated with sarcopenia [Odds ratio (OR) 1.447 (95%) confidence interval (CI) 1.170–1.791, p = 0.001; OR 1.127, (95%) CI 1.016–1.249, p = 0.023, respectively]. ROC curve analysis showed that the area under ROC curve (AUC) of SARC-F and MMP9/TIMP1 was 0.703 (p = 0.001, %95 CI 0.594–0.812) and 0.670 (p = 0.006, %95 CI 0.557–0.783), respectively.

Conclusion

Although this study supports the use of SARC-F questionnaire in daily practice; if SARC-F can’t be applicable, the MMP9/TIMP1 ratio could be an alternative choice to the SARC-F.

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Funding

This work was supported by The Research Fund of Istanbul University-Cerrahpasa (Project Number 33498).

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Correspondence to Veysel Suzan.

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The study has been approved by the ethics committee of the Cerrahpasa Medical Faculty.

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Written informed consent was obtained from each subject.

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Suzan, V., Yavuzer, H., Bag Soytas, R. et al. The relationship between primary sarcopenia and SARC-F, serum MMP9, TIMP1 levels, and MMP9/TIMP1 ratio in the geriatric patients. Eur Geriatr Med 12, 1229–1235 (2021). https://doi.org/10.1007/s41999-021-00519-y

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  • DOI: https://doi.org/10.1007/s41999-021-00519-y

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