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SERS Nanotags and Their Applications in Biosensing and Bioimaging

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Abstract

Owing to the unique advantages of surface enhanced Raman scattering (SERS) in high sensitivity, specificity, multiplexing capability and photostability, it has been widely used in many applications, among which SERS biosensing and bioimaging are the focus in recent years. The successful applications of SERS for non-invasive biomarker detection and bioimaging under in vitro, in vivo and ex vivo conditions, offer significant clinical information to improve diagnostic and prognostic outcomes. This review provides recent developments and applications of SERS, in particular SERS nanotags in biosensing and bioimaging, describing case studies in which different types of biomarkers have been investigated, as well as outlining future challenges that need to be addressed before SERS sees both pathological and clinical use.

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Acknowledgements

This work was supported by the Australian Research Council (ARC) Discovery Early Career Research Award (DECRA-DE 140101056) to Y.W.

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Authors and Affiliations

  1. Department of Molecular Sciences, Macquarie University, Sydney, NSW, 2109, Australia

    Wei Zhang & Yuling Wang

  2. ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP), Macquarie University, Sydney, NSW, 2109, Australia

    Wei Zhang, Lianmei Jiang, James A. Piper & Yuling Wang

  3. Department of Physics and Astronomy, Macquarie University, Sydney, NSW, 2109, Australia

    Lianmei Jiang & James A. Piper

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  1. Wei Zhang
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  2. Lianmei Jiang
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  3. James A. Piper
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  4. Yuling Wang
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Correspondence to Yuling Wang.

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Zhang, W., Jiang, L., Piper, J.A. et al. SERS Nanotags and Their Applications in Biosensing and Bioimaging. J. Anal. Test. 2, 26–44 (2018). https://doi.org/10.1007/s41664-018-0053-9

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  • DOI: https://doi.org/10.1007/s41664-018-0053-9

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