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Methodological study on endogenous calcium absorptivity using rats and 41Ca tracing

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Abstract

Elemental calcium plays an important role in human physiology. In order to study the relationship between Ca-intake, Ca-chemical formulation, and Ca-absorptivity, a balance experiment using a 41Ca tracer technique in SD rats was conducted to measure the endogenous fecal calcium and true absorption of calcium. Apparent absorption of calcium was measured as a control to the endogenous calcium labeling experiment. These results show that by using 41Ca labeled endogenous calcium in vivo, researchers could obtain the true calcium absorption data without extrinsic labeling. Therefore, the method was not affected by the chemical structure or type of calcium supplement and might be used in evaluating the absorptivity of marketed calcium supplements.

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Acknowledgements

We wish to thank experimentalist Lu Zheng from Beijing Union University for her help with the 41Ca biological tracer.

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Authors and Affiliations

  1. China Institute of Atomic Energy, Beijing, 102413, China

    Hui Zhang, Liang Dou, Xiao-Ming Wang, Qing-Zhang Zhao, Shan Jiang & Ming He

  2. Technical Physics Institute of Heilongjiang Academy of Sciences, Harbin, 150086, China

    Hui Zhang

  3. Department of Biology, College of Applied Arts and Sciences, Beijing Union University, Beijing, 100083, China

    Sheng-Quan Mi

Authors
  1. Hui Zhang
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  2. Liang Dou
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  3. Xiao-Ming Wang
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  4. Sheng-Quan Mi
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  5. Qing-Zhang Zhao
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  6. Shan Jiang
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  7. Ming He
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Corresponding author

Correspondence to Ming He.

Additional information

This work was supported by the National Nature Science Foundation of China (No. 11375272).

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Zhang, H., Dou, L., Wang, XM. et al. Methodological study on endogenous calcium absorptivity using rats and 41Ca tracing. NUCL SCI TECH 29, 56 (2018). https://doi.org/10.1007/s41365-018-0387-z

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