Cervical Lymphoma Mimicking Cervical Fibroid: A Report of Three Cases and Review of Literature

Abstract

Objective

Primary cervical lymphoma is a rare clinical condition among the Non-Hodgkin’s lymphomas. Here, we describe our experience with primary lymphoma of the cervix.

Methods

Chart review of patients with lymphoma of the cervix at tertiary care center in Southern India, during the period 2010–2012.

Results

Three cases of primary lymphoma of the cervix were identified from our records. The ages of these women were 54, 36, and 49. All three presented with vaginal bleeding and a cervical mass. The first patient had a large, infiltrative, smooth cervical mass, the biopsy of which was reported as a cervical lymphoma. The second patient had a cervical mass, diagnosed as cervical fibroid, and underwent a difficult hysterectomy. The final biopsy report was reported as cervical lymphoma. The last patient underwent hysterectomy elsewhere for cervical fibroid and presented to us 3 months later with a pelvic mass. Biopsy of this mass as well as the cervix (slide review) of the original specimen showed lymphoma. All the three patients underwent chemotherapy with R-CHOP. One patient died after her 12th cycle of chemotherapy, one patient is well at 16 months follow-up. The last patient decided to continue her chemotherapy in her home town.

Conclusion

Primary cervical lymphoma is a rare diagnosis often made after hysterectomy or large excision biopsy. The mainstay of treatment is chemotherapy and surgery is usually reserved for a persistent cervical mass.