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Collapsing focal segmental glomerulosclerosis successfully treated with combination of steroid pulse and low-density lipoprotein apheresis: lessons for the clinical nephrologist

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Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.

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References

  1. Stokes MB, Valeri AM, Markowitz GS, D’Agati VD (2006) Cellular focal segmental glomerulosclerosis: clinical and pathologic features. Kidney Int 70:1783–1792. https://doi.org/10.1038/sj.ki.5001903

    Article  CAS  PubMed  Google Scholar 

  2. Nicholas Cossey L, Larsen CP, Liapis H (2017) Collapsing glomerulopathy: a 30-year perspective and single, large center experience. Clin Kidney J 10:443–449. https://doi.org/10.1093/ckj/sfx029

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Albaqumi M, Soos TJ, Barisoni L, Nelson PJ (2006) Collapsing glomerulopathy. J Am Soc Nephrol 17:2854–2863. https://doi.org/10.1681/ASN.2006030225

    Article  CAS  PubMed  Google Scholar 

  4. Muso E, Mune M, Hirano T, Hattori M, Kimura K, Watanabe T, Yokoyama H, Sato H, Uchida S, Wada T, Shoji T, Yuzawa Y, Takemura T, Sugiyama S, Nishizawa Y, Ogahara S, Yorioka N, Sakai S, Ogura Y, Yukawa S, Iino Y, Imai E, Matsuo S, Saito T (2015) Immediate therapeutic efficacy of low-density lipoprotein apheresis for drug-resistant nephrotic syndrome: evidence from the short-term results from the POLARIS Study. Clin Exp Nephrol 19:379–386. https://doi.org/10.1007/s10157-014-0996-8

    Article  CAS  PubMed  Google Scholar 

  5. Muso E (2014) Beneficial effect of LDL-apheresis in refractory nephrotic syndrome. Clin Exp Nephrol 18:286–290. https://doi.org/10.1007/s10157-013-0930-5

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Ruan XZ, Varghese Z, Moorhead JF (2009) An update on the lipid nephrotoxicity hypothesis. Nat Rev Nephrol 5:713–721. https://doi.org/10.1038/nrneph.2009.184

    Article  CAS  PubMed  Google Scholar 

  7. Nakamura T, Kawagoe Y, Ogawa H, Ueda Y, Hara M, Shimada N, Ebihara I, Koide H (2005) Effect of low-density lipoprotein apheresis on urinary protein and podocyte excretion in patients with nephrotic syndrome due to diabetic nephropathy. Am J Kidney Dis 45:48–53. https://doi.org/10.1053/j.ajkd.2004.09.013

    Article  PubMed  Google Scholar 

  8. Thomas DB, Franceschini N, Hogan SL, Ten Holder S, Jennette CE, Falk RJ, Jennette JC (2006) Clinical and pathologic characteristics of focal segmental glomerulosclerosis pathologic variants. Kidney Int 69:920–926. https://doi.org/10.1038/sj.ki.5000160

    Article  CAS  PubMed  Google Scholar 

  9. Chun MJ, Korbet SM, Schwartz MM, Lewis EJ (2004) Focal segmental glomerulosclerosis in nephrotic adults: presentation, prognosis, and response to therapy of the histologic variants. J Am Soc Nephrol 15:2169–2177. https://doi.org/10.1097/01.ASN.0000135051.62500.97

    Article  PubMed  Google Scholar 

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Acknowledgements

We thank editage (http://www.editage.jp) for English language editing.

Funding

No funding was received for this study.

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Contributions

YF, MK, and YS provided the patient with medical treatment. YF, HH, and HH analyzed the renal histopathological findings. YF contributed to the conception and design of the study. YF acquired, analyzed and interpreted the data. YF drafted the manuscript. YF, HH, HH, and YS critically revised the manuscript for significant intellectual content. All authors have read and approved the final version for publication.

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Correspondence to Yoshitaka Furuto.

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This article does not contain any studies with human participants performed by any of the authors.

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Furuto, Y., Hashimoto, H., Kawamura, M. et al. Collapsing focal segmental glomerulosclerosis successfully treated with combination of steroid pulse and low-density lipoprotein apheresis: lessons for the clinical nephrologist. J Nephrol 35, 1279–1282 (2022). https://doi.org/10.1007/s40620-021-01213-9

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