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Maternal and neonatal outcomes of pregnancy complicated by urolithiasis: a systematic review and meta-analysis

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Abstract

Background

The effect of urolithiasis on pregnancy-related outcomes remains unknown. The aim of this study was to determine the risk of adverse maternal and neonatal outcomes.

Methods

We searched PubMed, Embase, and the Cochrane Library through December 2020 for studies reporting on adverse maternal and neonatal outcomes in patients with urolithiasis. Risk ratios (ORs) with 95% confidence intervals (CIs) were calculated for these outcomes in pregnant mothers with urolithiasis and compared to healthy controls.

Results

Eight studies comprising 26,577 mothers with urolithiasis were included in our analysis. Preterm birth (OR = 1.63; 95% CI 1.37–1.95, p < 0.001) or very preterm birth risk (OR = 1.49, 95% CI 1.06–2.11, p = 0.02) was more common in patients with urolithiasis compared to healthy controls. Mothers with urolithiasis had an increased incidence of preeclampsia (OR = 1.75, 95% CI 1.33–2.3, p < 0.001), hypertension (OR = 2.97, 95% CI 1.31–6.71, p = 0.009), caesarean section (OR 1.31, 95% CI 1.11–1.55, p = 0.001), and gestational diabetes mellitus (OR 1.84, 95% CI 1.37–2.46, p < 0.001).

Conclusion

Patients with urolithiasis may be at increased risk of developing adverse maternal or neonatal outcomes.

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Author information

Author notes

  1. Qin Zhou and Wen-Qing Chen are equal contribution.

Authors and Affiliations

  1. Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Qingchun Road 79, Hangzhou, 31000, People’s Republic of China

    Qin Zhou, Wen-Qing Chen, Xi-Shao Xie, Shi-Long Xiang, Hao Yang & Jiang-Hua Chen

  2. Key Laboratory of Nephropathy, Hangzhou, People’s Republic of China

    Qin Zhou, Wen-Qing Chen, Xi-Shao Xie, Shi-Long Xiang, Hao Yang & Jiang-Hua Chen

  3. Kidney Disease Immunology Laboratory, The Third-Grade Laboratory, State Administration of Traditional Chinese Medicine of China, Hangzhou, People’s Republic of China

    Qin Zhou, Wen-Qing Chen, Xi-Shao Xie, Shi-Long Xiang, Hao Yang & Jiang-Hua Chen

  4. Key Laboratory of Multiple Organ Transplantation, Ministry of Health, Hangzhou, People’s Republic of China

    Qin Zhou, Wen-Qing Chen, Xi-Shao Xie, Shi-Long Xiang, Hao Yang & Jiang-Hua Chen

  5. Institute of Nephropathy, Zhejiang University, Hangzhou, People’s Republic of China

    Qin Zhou, Wen-Qing Chen, Xi-Shao Xie, Shi-Long Xiang, Hao Yang & Jiang-Hua Chen

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  1. Qin Zhou
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Contributions

QZ and JHC conceived the study and revised the manuscript critically for important intellectual content. QZ and WQC made substantial contributions to its design, acquisition, analysis and interpretation of data. XSX, SLX, and HY participated in the design, acquisition, analysis and interpretation of data. All authors read and approved the final manuscript.

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Correspondence to Jiang-Hua Chen.

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Zhou, Q., Chen, WQ., Xie, XS. et al. Maternal and neonatal outcomes of pregnancy complicated by urolithiasis: a systematic review and meta-analysis. J Nephrol 34, 1569–1580 (2021). https://doi.org/10.1007/s40620-021-01093-z

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  • DOI: https://doi.org/10.1007/s40620-021-01093-z

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