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A community-based study of reporting demographic and clinical information concordance between informants and cognitively impaired participants

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Abstract

Background

Understanding concordance between informants’ and cognitively impaired participants’ information reporting is crucial for Alzheimer’s and Alzheimer’s-related dementia studies.

Methods

The Brain Attack Surveillance in Corpus Christi-Cognitive is a community-based cohort study. Households in Nueces County, Texas, USA, were randomly identified. 330 dyads of participants and their named informants answered questions. Models were generated to examine which predictors, including age, gender, ethnicity, cognitive function, and relationship to informant, influenced answer discordance.

Results

For demographic items, female participants and participants with spouses/partners as informants had significantly less discordance, with incidence rate rations (IRRs) of 0.65 (CI = 0.44, 0.96) and 0.41 (CI = 0.23, 0.75), respectively. For health items, better cognitive function of the participant was associated with less discordance, with an IRR of 0.85 (CI = 0.76, 0.94).

Conclusions

Demographic information concordance is most associated with gender and informant–participant relationship. Level of cognitive function is most associated with concordance for health information.

ClinicalTrials.gov identifier NCT03403257.

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Data availability

Reasonable requests for data sharing will be considered by the corresponding author based on IRB approvals and existing data use agreements.

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Funding

This study was supported by National Institues of Health, R01NS100687.

Author information

Authors and Affiliations

  1. Department of Neurology, University of Michigan Medical School, 1500 E. Medical Center Drive, CVC 3194, Ann Arbor, MI, 48109-5855, USA

    Noreen Khan, Emily M. Briceño, Nelda Garcia, Deborah A. Levine & Lewis B. Morgenstern

  2. Department of Physical Medicine and Rehabilitation, University of Michigan Medical School, Ann Arbor, MI, USA

    Emily M. Briceño

  3. School of Public Health, Department of Health Behavior and Health Education, University of Michigan, Ann Arbor, MI, USA

    Roshanak Mehdipanah

  4. University of Michigan Institute for Social Research, Ann Arbor, MI, USA

    Lisa Lewandowski-Romps, Steven G. Heeringa & Kenneth M. Langa

  5. Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA

    Deborah A. Levine & Kenneth M. Langa

  6. Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI, USA

    Kenneth M. Langa

  7. Center for Social Epidemiology and Population Health, University of Michigan School of Public Health, Ann Arbor, MI, USA

    Lewis B. Morgenstern

Authors
  1. Noreen Khan
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  2. Emily M. Briceño
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  3. Roshanak Mehdipanah
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  4. Lisa Lewandowski-Romps
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  5. Steven G. Heeringa
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  6. Nelda Garcia
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  7. Deborah A. Levine
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  8. Kenneth M. Langa
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  9. Lewis B. Morgenstern
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Contributions

NK, LL-R, SGH, and LBM contributed to writing. LL-R and SGH contributed to data curation and analysis. EB, RM, KL, DL, and LBM contributed to research design, conceptualization, and methodology. NG conducted data collection.

Corresponding author

Correspondence to Lewis B. Morgenstern.

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Conflict of interest

The authors report no competing interests other than funding from academic organizations and the NIH. This work was supported from NIH Grant R01NS100687.

Ethical approval

As per the University of Michigan Institutional Review Board approval, informed consent was provided by the informant for both informant and participants since the participants were by definition cognitively impaired.

Statement of human and animal rights

This project was approved by the University of Michigan IRB.

Informed consent

Caregivers provided informed consent for themselves and the cognitively impaired participants.

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Khan, N., Briceño, E.M., Mehdipanah, R. et al. A community-based study of reporting demographic and clinical information concordance between informants and cognitively impaired participants. Aging Clin Exp Res 35, 1571–1576 (2023). https://doi.org/10.1007/s40520-023-02435-6

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  • DOI: https://doi.org/10.1007/s40520-023-02435-6

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