Skip to main content
SpringerLink
Log in

Z-drugs and falls in nursing home patients: data from the INCUR study

  • Short Communication
  • Published:
Aging Clinical and Experimental Research Aims and scope Submit manuscript

Abstract

Background

Z-drugs are the most prescribed treatment for insomnia, but their negative effect on the body sway can increase the risk of falls.

Aims

Evaluating the association between Z-drugs and falls in a resident cohort.

Methods

Prospective observational study using the data collected in the Incidence of pNeumonia and related ConseqUences in nursing home Residents (INCUR) study.

Results

During the one-year follow-up, among the 800 participants (median age 87), 93 individuals fell (64 fracturing and 29 without fracturing). Lower calf circumference (adjusted OR 0.92, 95% CI 0.86–0.97, p = 0.006) and the use of selective serotonin reuptake inhibitors (adjusted OR 1.86, 95% CI 1.1–3.05, p = 0.01) predicted falls, whereas the use of Z-drugs (adjusted OR 2.37, 95% CI 1.13–4.94, p = 0.02) and lower body mass index (adjusted OR 0.9, 95% CI 0.84–0.97, p = 0.005) were associated with falls without fractures.

Conclusions

Z-drugs predicted falls without fractures in residents. Alternative strategies to promote sleep in residents should be pursued.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. De Souto BP, Lapeyre-Mestre M, Mathieu C et al (2013) Indicators of benzodiazepine use in nursing home residents in France: a cross-sectional study. J Am Med Dir Assoc 14:29–33

    Article  Google Scholar 

  2. Aronson J (2009) Hypnosedatives. Meyler’s side effects of psychiatric drugs. Elsevier, Amsterdam, pp 375–450

    Google Scholar 

  3. Berry SD, Lee Y, Cai S et al (2013) Nonbenzodiazepine sleep medication use and hip fractures in nursing home residents. JAMA Intern Med 173:754–761

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  4. Demougeot L, Rolland Y, Gérard S et al (2013) Incidence and economical effects of pneumonia in the older population living in French nursing homes: design and methods of the INCUR study. BMC Public Health 17:861

    Article  Google Scholar 

  5. Damanti S, Ramirez GA, Da Prat V et al (2022) Selective serotonin reuptake inhibitors and fractures in older nursing home residents: data from the INCUR study. Maturitas. https://doi.org/10.1016/j.maturitas.2021.11.012

    Article  PubMed  Google Scholar 

  6. Tang Y-J, Ho S-Y, Chu F-Y et al (2015) Is zolpidem associatedwith increased risk of fractures in the elderly withsleep disorders? a nationwide case cross-overstudy in Taiwan. PLoS ONE 10:e0146030

    Article  PubMed  PubMed Central  Google Scholar 

  7. Wang PS, Bohn RL, Glynn RJ et al (2001) Zolpidem use and hip fractures in older people. J Am Geriatr Soc 49:1685–1690

    Article  PubMed  CAS  Google Scholar 

  8. Kang DY, Park S, Rhee CW et al (2012) Zolpidem use and risk of fracture in elderly insomniapatients. J Prev Med Public Health 45:219–226

    Article  PubMed  PubMed Central  Google Scholar 

  9. Treves N, Perlman A, Geron LK et al (2018) Z-drugs and risk for falls and fractures in older adults-a systematic review and meta-analysis. Age Ageing 47:201–208

    Article  PubMed  Google Scholar 

  10. Choi EJ, Lee YS, Yang EJ et al (2017) Characteristics and risk factors for falls in tertiary hospital inpatients. J Korean Acad Nurs 47:420–430

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

The INCUR project was supported by Pfizer. We thank Dr. Luca Mollo and Dr.Sedipeh Attal at Pfizer for their help and assistance. We also thank all thepeople who made the INCUR project possible, in particular the clinicaland administrative personnel of the participating nursing homes: CentreHospitalier de Castelnaudary, De Vinci, Faux-Bourg Saint Adrien, Jean Loubès, Le Pastel, Domaine de Lasplanes, La Triade, Le Castelou, Le Garnagues, Maréchal Leclerc, Montréal, Saint Jacques, Saint Joseph.

Funding

The INCUR study was funded by Pfizer. The funding agency had no role in the design and conduction of the study, as well as in the writing of the present report.

Author information

Authors and Affiliations

  1. Unit of General Medicine and Advanced Care, IRCCS San Raffaele Institute, Milan, Italy

    Sarah Damanti & Moreno Tresoldi

  2. Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse (CHU Toulouse), 31000, Toulouse, France

    Philipe de Souto Barreto & Yves Rolland

  3. UMR INSERM 1027, University of Toulouse III, 31000, Toulouse, France

    Philipe de Souto Barreto & Yves Rolland

  4. Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

    Matteo Cesari

  5. Geriatric Unit, IRCCS Istituti Clinici Scientifici Maugeri, Milan, Italy

    Matteo Cesari

Authors
  1. Sarah Damanti
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Moreno Tresoldi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Philipe de Souto Barreto
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yves Rolland
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Matteo Cesari
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

SD: had a substantial contribution in conception or design of the work, drafting the work and approving the final version to be published. MT: had a substantial contribution in the design of the work, in revising the work critically for important intellectual content and in approving the final version to be published, PDSB and YR: had a substantial contribution in the acquisition, analysis, and interpretation of data for the work, revising the work critically for important intellectual content and approving the final version to be published, MC: had a substantial role in the conception and design of the work, in the acquisition, analysis and interpretation of data for the work, in revising the work critically for important intellectual content and in approving the final version to be published.

Corresponding author

Correspondence to Sarah Damanti.

Ethics declarations

Conflict of interest

The authors report no conflicts with any product mentioned or concept discussed in this article.

Ethical approval

The Ethics Committee of the Centre Hospitalier Universitaire de Toulouse and the Consultative Committee for the Treatment of Research Information on Health approved the study.

Informed consent

The Ethics Committee dispensed from the collection of written informed consents because of the epidemiological nature of the study.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file1 (DOCX 20 KB)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Damanti, S., Tresoldi, M., de Souto Barreto, P. et al. Z-drugs and falls in nursing home patients: data from the INCUR study. Aging Clin Exp Res 34, 3145–3149 (2022). https://doi.org/10.1007/s40520-022-02237-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40520-022-02237-2

Keywords

Search

Navigation