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The relationship between all-cause mortality sarcopenia and sarcopenic obesity among hospitalized older people

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Abstract

Background and aim

Sarcopenia and sarcopenic obesity (SO) are associated with adverse health outcomes in older people. Data on sarcopenia- and SO-related mortality are insufficient for hospitalized older people. The aim of this study was to evaluate the relationship between sarcopenia, SO and mortality among hospitalized older people.

Methods

Two-centered prospective observational study was conducted among 350 hospitalized older people in geriatric units of two university hospitals. Sarcopenia was defined according to the European Working Group on Sarcopenia in Older People. Obesity was defined according to fat mass percentage. Medical history, cognitive status, nutritional status and functionality and laboratory tests were assessed. All-cause mortality rate was recorded at 2 years.

Results

The prevalence of SO was 21.1%. The prevalence of sarcopenia was 11.4%. Both sarcopenia (log rank p < 0.001) and SO (log rank p < 0.001) were associated with all-cause mortality at 2 years. There was no difference between sarcopenia and SO for mortality. SO (HR 5.23, p < 0.001), sarcopenia (HR 9.26, p < 0.001), male gender (HR 2.25, p = 0.035), Lawton IADL (HR 0.77, p = 0.02), heart failure (HR 3.25, p = 0.02) and chronic obstructive lung disease (HR 5.16, p = 0.01) were independently related to all-cause mortality.

Discussion and conclusions

Both sarcopenia and SO showed an independent relationship for 2-year all-cause mortality after hospital discharge. These results suggest that preventive and treatment options should be taken to decrease mortality associated with these conditions among hospitalized older people.

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Acknowledgements

This study was granted by the scientific research project department of Yildirim Bayazit University School of University under protocol number 1207.

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Authors and Affiliations

  1. Department of Geriatric Medicine, Ankara University School of Medicine, Ankara, Turkey

    Volkan Atmis, Remzi Bahsi, Tugba Turgut, Deniz Mut Sürmeli, Hande Selvi Öztorun, Çağlar Çoşarderelioğlu, Sevgi Aras & Murat Varli

  2. Department of Geriatric Medicine, Ataturk’s Training and Research Hospital, Ankara, Turkey

    Ahmet Yalcin, Sumeyye Ulutas & Samet Yaman

  3. Gazi Osman Paşa-Ankara, Turkey

    Ahmet Yalcin

  4. Department of Geriatric Medicine, Yildirim Bayazit University School of Medicine, Ankara, Turkey

    Kamile Silay

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  1. Volkan Atmis
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  2. Ahmet Yalcin
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Correspondence to Ahmet Yalcin.

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The authors declare that there is no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee (the Research Ethics Committee of Yildirim Bayazit University School of Medicine approved the project under Protocol No. 1207) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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All study participants or their proxy provided written informed consent.

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Atmis, V., Yalcin, A., Silay, K. et al. The relationship between all-cause mortality sarcopenia and sarcopenic obesity among hospitalized older people. Aging Clin Exp Res 31, 1563–1572 (2019). https://doi.org/10.1007/s40520-019-01277-5

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  • DOI: https://doi.org/10.1007/s40520-019-01277-5

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