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Higher orthostatic heart rate predicts mortality: The Irish Longitudinal Study on Ageing (TILDA)

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Abstract

Background

Orthostatic hemodynamic signals may predict adverse outcomes in elders.

Aims

To study the association between orthostatic hemodynamics and incident mortality in The Irish Longitudinal Study on Ageing (TILDA).

Methods

Wave 1 subjects underwent an active stand with non-invasive beat-to-beat blood pressure monitoring. We compared wave 1 active stands, dead vs alive in wave 2.

Results

Compared to the 4,415 participants who had not died, the 53 who had died had a higher baseline heart rate [HR mean of 69 vs 65 beats per minute (bpm)] and a higher mean orthostatic HR, especially between 30 and 60 s post-stand (mean of 79 vs 73 bpm). After adjusting for age, sex, baseline HR, mini-mental state examination score and cardiovascular comorbidities and medications, the mean HR between 30 and 60 s post-stand independently predicted mortality (baseline HR did not).

Discussion

Higher early orthostatic HR may be an independent risk marker. Further validation is required.

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Fig. 1

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Acknowledgments

Funding was gratefully received from the Atlantic Philanthropies, The Irish Government, and Irish Life plc. The sponsors played no part in the design, methods, subject recruitment, data collection, analysis, or preparation of this paper.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical standards

Ethical approval was obtained from the Trinity College Dublin Research Ethics Committee, and all participants provided written informed consent.

Author information

Authors and Affiliations

  1. The Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, Lincoln Gate, Dublin 2, Republic of Ireland

    Roman Romero-Ortuno, Matthew D. L. O’Connell, Ciarán Finucane, Chie Wei Fan & Rose Anne Kenny

Authors
  1. Roman Romero-Ortuno
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  2. Matthew D. L. O’Connell
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  3. Ciarán Finucane
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  4. Chie Wei Fan
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  5. Rose Anne Kenny
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Corresponding author

Correspondence to Roman Romero-Ortuno.

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Romero-Ortuno, R., O’Connell, M.D.L., Finucane, C. et al. Higher orthostatic heart rate predicts mortality: The Irish Longitudinal Study on Ageing (TILDA). Aging Clin Exp Res 27, 239–242 (2015). https://doi.org/10.1007/s40520-014-0261-8

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  • DOI: https://doi.org/10.1007/s40520-014-0261-8

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