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Interleukin-10 promoter (−1082) polymorphism in association with repeated hospital-acquired infections in elderly patients

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Abstract

Background

Infections are frequent complications of hospitalization, particularly in the elderly. Pro- and anti-inflammatory cytokines are essential components of the host response to pathogens and polymorphisms in their genes may contribute to inter-individual variations of the inflammatory response. The aim of this study was to investigate whether cytokine polymorphisms, separately or in combination, could be determining factors in the development of repeated nosocomial infections in elderly hospitalized patients.

Methods

Tumor necrosis factor-α (−308) and (−238), interleukin-6 (−174) and (−6331), interleukin-10 (−1082) and (−592) polymorphisms were genotyped by PCR and hybridization with fluorescent-labeled probes in 245 hospitalized elderly patients (mean age 85.2 years; SD 6) and compared with those in 145 healthy adults.

Results

The distribution of genotypes did not differ between elderly patients and control subjects. The presence of the interleukin-10 A592 or A1082 allele was more frequent individually and after adjustment for multiple comparisons in patients who suffered from several infections (p = 0.012, odds ratio = 5.3; 95 % confidence interval = 1.2–23.1).

Conclusion

Our data support a determinant role for interleukin-10 (−1082) polymorphism in the development of nosocomial infections.

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Abbreviations

TNF:

Tumor necrosis factor

IL:

Interleukin

SNP:

Single nucleotide polymorphism

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Acknowledgments

This work was supported by the Soins Courants 2006 grant SCR06010 from the French Ministry of Health, Direction de la Recherche Clinique.

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None.

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Authors and Affiliations

  1. Service de Biochimie, Assistance Publique-Hôpitaux de Paris (APHP), Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, Paris, 75679 Paris cedex 04, France

    Phuong-Nhi Bories, Lydie Denjean & Theodora Popovici

  2. Département de Médecine Interne et Gériatrie, Assistance Publique-Hôpitaux de Paris (APHP), Hôpital Henri-Mondor, Créteil, 94010, France

    Marie Laurent, Evelyne Liuu & Elena Paillaud

  3. Faculté de Médecine, Université Paris Est, LIC EA 4393, Créteil, 94010, France

    Marie Laurent & Elena Paillaud

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  1. Phuong-Nhi Bories
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  2. Marie Laurent
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Correspondence to Phuong-Nhi Bories.

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Bories, PN., Laurent, M., Liuu, E. et al. Interleukin-10 promoter (−1082) polymorphism in association with repeated hospital-acquired infections in elderly patients. Aging Clin Exp Res 26, 25–31 (2014). https://doi.org/10.1007/s40520-013-0177-8

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  • DOI: https://doi.org/10.1007/s40520-013-0177-8

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