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Poor kidney graft survival in anorexia nervosa patients

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Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity Aims and scope Submit manuscript

Abstract

Background

Anorexia nervosa is a condition associated with poor outcomes in a variety of circumstances such as recurrence of eating disorders, psychiatric disorders, and organ damage.

Objective

In the present study, we first sought to determine the 5-year kidney graft survival in patients with anorexia nervosa and then to evaluate the BMI course and medical complications.

Methods

In this multicenter, retrospective, case–control study, we analyzed the impact of anorexia nervosa on graft outcomes compared to transplant recipients with low or normal BMI.

Results

We enrolled 137 women in this study: 19 with anorexia nervosa, 59 with low BMI (BMI < 18.5 kg/m2), and 59 with normal BMI (18.5–24.9 kg/m2). Anorexia nervosa was significantly associated with lower graft survival compared to either of the other groups (hazard ratio 5.5 [95% CI 3.4–8.9], p = 0.005); there was no difference in graft survival between patients with low or normal BMI. Cardiovascular complications were more frequent in the anorexia nervosa group (37%) than in patients with low (6%) or normal BMI (7%) (p = 0.001).

Conclusion

We conclude that patients with anorexia nervosa should be considered a high-risk group.

Level of evidence

Level III, evidence obtained from well-designed cohort or case–control analytic studies.

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Abbreviations

CKD:

Chronic kidney disease

CMV:

Cytomegalovirus

DGF:

Delayed graft function

ECD:

Expanded criteria donor

ESRD:

End stage renal disease

GFR:

Glomerular filtration rate

KT:

Kidney transplantation

SD:

Standard deviation

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Acknowledgements

We thank Professor Henri Kreis for his help throughout this work.

Author information

Authors and Affiliations

  1. Service de Néphrologie Dialyse, Hôpital Privé Francheville, 4 Place Francheville, 24000, Périgueux, France

    Magalie Geneviève

  2. Service de Néphrologie Dialyse Transplantation, Hôpital Foch, Suresnes, France

    Albane Sartorius

  3. Centre Hospitalier Universitaire de Nantes, Institut Transplantation Urologie Néphrologie, Nantes, France

    Magali Giral

  4. Université de Nantes, Nantes, France

    Magali Giral

  5. Service Néphrologie-Transplantation Rénale-Dialyse, Centre Hospitalier Universitaire de Grenoble, Grenoble, France

    Bénédicte Janbon

  6. Service de Néphrologie Transplantation Dialyse, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France

    Magalie Geneviève, Pierre Merville, Christian Combe & Karine Moreau

  7. Université de Bordeaux, Bordeaux, France

    Pierre Merville & Christian Combe

  8. Service de Néphrologie Dialyse Transplantation, Hôpital Necker, Paris, France

    Christophe Legendre

  9. Hôpital Necker, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes, Paris, France

    Christophe Legendre

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  1. Magalie Geneviève
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  2. Albane Sartorius
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  3. Magali Giral
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  4. Bénédicte Janbon
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  5. Pierre Merville
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Correspondence to Magalie Geneviève.

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The authors declare that they have no conflict of interest.

Research involving human participants

Ethical approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Ethical approval was waived by the local Ethics Committee of Medical University of Bordeaux in view of the retrospective nature of the study and all the procedures being performed were part of the routine care.

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Geneviève, M., Sartorius, A., Giral, M. et al. Poor kidney graft survival in anorexia nervosa patients. Eat Weight Disord 26, 1447–1455 (2021). https://doi.org/10.1007/s40519-020-00959-8

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  • DOI: https://doi.org/10.1007/s40519-020-00959-8

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