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Dear Editor,
We appreciate the interest in our article and thank Dr. Beuy Joob for his knowledgeable comments on our study. Non-coding variants (rs17782313) of the MC4R have been related to susceptibility to polygenic obesity [1]. Therefore, we agree that additional SNPs within the MC4R gene, also SNPs in other genes implicated in the pathogenesis of obesity and cardio-metabolic factors, may be involved, and these should be considered and assessed in further studies. However, our study provides valuable information, as a hypothesis, to be evaluated by cohort studies [2, 3]. Moreover, we agree that other lifestyle and environmental factors could affect our observed results and as well as, the confounding role of other unknown factors is undeniable. Further studies should mostly focus on the effect of polygenic interactions between obesity and its metabolic risk factors.
Reference
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Mohammadi M, Khodarahmi M, Kahroba H, Farhangi MA (2020) Dietary patterns interact with the variations of 18q21.23 rs17782313 locus on regulation of hypothalamicpituitary axis hormones and cardio-metabolic risk factors in obesity. Eat Weight Disord. https://doi.org/10.1007/s40519-020-00855-1(Epub ahead of print)
Mahmoudi-Nezhad M, Farhangi MA, Kahroba H (2020) Cocaine and amphetamine regulated transcript prepropeptide gene (CARTPT) polymorphism interacts with Diet Quality Index-International (DQI-I) and Healthy Eating Index (HEI) to affect hypothalamic hormones and cardio-metabolic risk factors among obese individuals. J Transl Med 18(1):16. https://doi.org/10.1186/s12967-020-02208-z
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Khodarahmi, M., Farhangi, M.A. & Mohammadi, M. Gene- diet interaction of 18q21.23 rs17782313 locus and dietary patterns in regulation of hypothalamic-pituitary axis hormones and cardio-metabolic risk factors in obesity. Eat Weight Disord 25, 1497 (2020). https://doi.org/10.1007/s40519-020-00889-5
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DOI: https://doi.org/10.1007/s40519-020-00889-5