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Relationship between the overall survival in glioblastomas and the radiomic features of intraoperative ultrasound: a feasibility study

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Abstract

Purpose

Predicting the survival of patients diagnosed with glioblastoma (GBM) is essential to guide surgical strategy and subsequent adjuvant therapies. Intraoperative ultrasound (IOUS) can contain biological information that could be correlated with overall survival (OS). We propose a simple extraction method and radiomic feature analysis based on IOUS imaging to estimate OS in GBM patients.

Methods

A retrospective study of surgically treated glioblastomas between March 2018 and November 2019 was performed. Patients with IOUS B-mode and strain elastography were included. After preprocessing, segmentation and extraction of radiomic features were performed with LIFEx software. An evaluation of semantic segmentation was carried out using the Dice similarity coefficient (DSC). Using univariate correlations, radiomic features associated with OS were selected. Subsequently, survival analysis was conducted using Cox univariate regression and Kaplan–Meier curves.

Results

Sixteen patients were available for analysis. The DSC revealed excellent agreement for the segmentation of the tumour region. Of the 52 radiomic features, two texture features from B-mode (conventional mean and the grey-level zone length matrix/short-zone low grey-level emphasis [GLZLM_SZLGE]) and one texture feature from strain elastography (grey-level zone length matrix/long-zone high grey-level emphasis [GLZLM_LZHGE]) were significantly associated with OS. After establishing a cut-off point of the statistically significant radiomic features, we allocated patients in high- and low-risk groups. Kaplan–Meier curves revealed significant differences in OS.

Conclusion

IOUS-based quantitative texture analysis in glioblastomas is feasible. Radiomic tumour region characteristics in B-mode and elastography appear to be significantly associated with OS.

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Data availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Acknowledgements

We thank all the members of the Radiology Department of our hospital for their support in carrying out this work.

Funding

No funding was received for this research.

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Authors and Affiliations

  1. Department of Neurosurgery, University Hospital Río Hortega, Calle Dulzaina, 2, 47012, Valladolid, Spain

    Santiago Cepeda, Sergio García-García, Ignacio Arrese & Rosario Sarabia

  2. Department of Radiology, University Hospital Río Hortega, Calle Dulzaina, 2, 47012, Valladolid, Spain

    María Velasco-Casares

Authors
  1. Santiago Cepeda
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  2. Sergio García-García
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  3. Ignacio Arrese
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  4. María Velasco-Casares
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  5. Rosario Sarabia
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by SG-G, RS, MV-C and IA. The first draft of the manuscript was written by SC and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Santiago Cepeda.

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Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers' bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the Ethics Committee of our center and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Cepeda, S., García-García, S., Arrese, I. et al. Relationship between the overall survival in glioblastomas and the radiomic features of intraoperative ultrasound: a feasibility study. J Ultrasound 25, 121–128 (2022). https://doi.org/10.1007/s40477-021-00569-9

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  • DOI: https://doi.org/10.1007/s40477-021-00569-9

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