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Is the Diet Industry Disrupting Your Microbiota?

  • Metabolism in Tropical Medicine (K Schlosser Montes, Section Editor)
  • Published:
Current Tropical Medicine Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Gut microbes are essential to human health and dietary patterns can influence bacterial diversity and abundance, resulting in either health or disease. Here, we review if high-fat diets motivated by the diet industry can result in disruption of microbiota, which in turn leads to disease.

Recent Findings

A high-fat diet induces microbiota dysbiosis, which is related to obesity and chronic diseases. Some mechanisms include higher bile acid secretion, which conduct its detergent effect on bacterial cell membranes, inducing the loss of non-bile-resistant species. In addition, by adopting a low-carbohydrate dietary pattern, microorganisms are deprived from short-chain fatty acids.

Summary

Evidence shows that a high-fat diet can unchain dysbiosis resulting in chronic illness and obesity.

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Abbreviations

BMI:

body mass index

CNS:

central nervous system

HFD:

high-fat diet

KD:

ketogenic diet

LPL:

lipopolysaccharides

MD:

Mediterranean diet

SCFAs:

short-chain fatty acids

TJs:

tight junctions

TMAO:

TMA-N-oxide

VLCD:

very low–carbohydrate diet

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Authors and Affiliations

  1. Guatemala, Guatemala

    Elisa M. Sinibaldi & Ana María Zelaya

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  1. Elisa M. Sinibaldi
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Sinibaldi, E.M., Zelaya, A.M. Is the Diet Industry Disrupting Your Microbiota?. Curr Trop Med Rep 6, 256–262 (2019). https://doi.org/10.1007/s40475-019-00189-8

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