Skip to main content

Advertisement

Log in

Alcohol use and Depression During Adolescence and Young Adulthood: a Summary and Interpretation of Mixed Findings

  • Alcohol (RF Leeman, Section Editor)
  • Published:
Current Addiction Reports Aims and scope Submit manuscript

Abstract

Alcohol use disorder (AUD) and alcohol misuse are common among adolescents and young adults and are associated with significant personal and societal problems. Similarly, major depressive disorder (MDD) and depressive symptoms are prevalent in this population and when they co-occur with alcohol misuse leads to even more severe consequences. Numerous studies have investigated the association between depressive symptoms, AUD, and various drinking behaviors presenting an unclear picture. In this review, we summarize studies among adolescents and young adults that have examined these relationships. From this review, it emerges that several factors affect results, including study design (cross-sectional vs longitudinal), participants’ age (adolescents vs young adults), severity of problems considered (AUD vs heavy drinking; MDD vs depressive symptoms), and gender. Adolescents with AUD are at higher risk for MDD in particular at a younger age. During adolescence, several drinking behaviors, including weekly alcohol use and heavy drinking, increase the risk for depressive symptoms and MDD, while during young adulthood primarily AUD, but not other drinking behaviors, is associated with increased risk for MDD. Gender may have an effect on the association between depression and drinking behaviors but its role is still unclear. Some evidence suggests that the association between AUD and MDD is bidirectional such that mood problems contribute to the onset of alcohol problems and vice versa. More longitudinal studies are needed to examine these associations in young adults and to clarify the effect of gender on these associations. To date, findings suggest the critical need to reduce any alcohol use at a young age and to treat both depressive symptoms and AUD to prevent the occurrence of comorbid disorders.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. Pedrelli P, Nyer M, Yeung A, Zulauf C, Wilens T. College students: mental health problems and treatment considerations. Acad Psychiatry. 2015;39(5):503–11.

    Article  PubMed Central  PubMed  Google Scholar 

  2. Kessler RC et al. Age of onset of mental disorders: a review of recent literature. Curr Opin Psychiatry. 2007;20(4):359–64.

    Article  PubMed Central  PubMed  Google Scholar 

  3. Center for Behavioral Health Statistics and Quality. Behavioral health trends in the United States: results from the 2014 National Survey on Drug Use and Health (HHS Publication No. SMA 15–4927, NSDUH Series H-50). 2015. Retrieved from http://www.samhsa.gov/data/.

  4. Wechsler H, Davenport A, Dowdall G, Moeykens B, Castillo S. Health and behavioral consequences of binge drinking in college: a national survey of students at 140 campuses. J Am Med Assoc. 1994;272:1672–7.

    Article  CAS  Google Scholar 

  5. Alcoholism, N.I.o.A.A.a., Moderate & binge drinking, 2013.

  6. Glasheen C, Pemberton MR, Lipari R, Copello EA, Mattson ME. Binge drinking and the risk of suicidal thoughts, plans, and attempts. Addict Behav. 2015;43:42–9.

    Article  PubMed  Google Scholar 

  7. Baliunas D, Rehm J, Irving H, Shuper P. Alcohol consumption and risk of incident human immunodeficiency virus infection: a meta-analysis. Int J Public Health. 2010;55(3):159–66.

    Article  PubMed  Google Scholar 

  8. Marlatt GA et al. Screening and brief intervention for high-risk college student drinkers: results from a 2-year follow-up assessment. J Consult Clin Psychol. 1998;66(4):604–15.

    Article  CAS  PubMed  Google Scholar 

  9. Hingson RW, Edwards EM, Heeren T, Rosenbloom D. Age of drinking onset and injuries, motor vehicle crashes, and physical fights after drinking and when not drinking. Alcohol Clin Exp Res. 2009;33(5):783–90.

    Article  PubMed Central  PubMed  Google Scholar 

  10. Jackson KM et al. Transitioning into and out of large-effect drinking in young adulthood. J Abnorm Psychol. 2001;110(3):378–91.

    Article  CAS  PubMed  Google Scholar 

  11. Johnston LD. Monitoring the future national results on adolescent drug use-overview of key findings 2006, vol. 2006. Bethesda: National Institute on Drug Abuse; 2007. NIH Publication No 07–6202.

    Google Scholar 

  12. Jennison KM. The short-term effects and unintended long-term consequences of binge drinking in college: a 10-year follow-up study. Am J Drug Alcohol Abuse. 2004;30(3):659–84.

    Article  PubMed  Google Scholar 

  13. Bouchery EE, Harwood HJ, Sacks JJ, Simon CJ, Brewer RD. Economic costs of excessive alcohol consumption in the U.S., 2006. Am J Prev Med. 2011;41(5):516–24.

    Article  PubMed  Google Scholar 

  14. Cassano P, Fava M. Depression and public health: an overview. J Psychosom Res. 2002;52:849–57.

    Article  Google Scholar 

  15. Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005;62:593–602.

    Article  PubMed  Google Scholar 

  16. Kessler RC, Berglund P, Demler O, Jin R, Koretz D, Merikangas KR, et al. The epidemiology of major depressive disorder: results from the national comorbidity survey replication (NCS-R). J Am Med Assoc. 2003;289:3095–105.

    Article  Google Scholar 

  17. Murray CJL, Lopez AD, editors. The global burden of disease. A comprehensive assessment of mortality and disability from diseases, injuries, and risk factors in 1990 and projected to 2020. Cambridge: Harvard University Presss; 1996.

    Google Scholar 

  18. Druss BG, Rosenheck RA, Sledge WH. Health and disability costs of depressive illness in a major U.S. corporation. Am J Psychiatry. 2000;157:1274–8.

    Article  CAS  PubMed  Google Scholar 

  19. Hankin BL, Abramson LY, Moffitt TE, Silva PA, McGee R, Angell KE. Development of depression from preadolescence to young adulthood: emerging gender differences in a 10-year longitudinal study. J Abnorm Psychol. 1998;107:128–40.

    Article  CAS  PubMed  Google Scholar 

  20. Zisook S et al. Effect of age at onset on the course of major depressive disorder. Am J Psychiatry. 2007;164(10):1539–46.

    Article  PubMed  Google Scholar 

  21. American College Health Association. American College Health Association-National College Health Assessment II: reference group executive summary fall 2011. Hanover: American College Health Association; 2012.

    Google Scholar 

  22. Steinberg L, Morris AS. Adolescent development. Annu Rev Psychol. 2001;52:83–110.

    Article  CAS  PubMed  Google Scholar 

  23. Arnett JJ, Ramos KD, Jensen LA. Ideologies in emerging adulthood: balancing the ethics of autonomy and community. J Adult Dev. 2001;8:69–79.

    Article  Google Scholar 

  24. Ge X, Lorenz FO, Conger RD, Elder Jr GH, Simons RL. Trajectory of stressful life events and depressive symptoms during adolescence. Dev Psychol. 1994;30:467–83.

    Article  Google Scholar 

  25. Mazure CM. Life stressors as risk factors in depression. Clin Psychol Sci Pract. 1998;5:291–313.

    Article  Google Scholar 

  26. Abela JRZ, Skitch SA. Dysfunctional attitudes, self-esteem, and hassles: cognitive vulnerability to depression in children of affectively ill parents. Behav Res Ther. 2006;45:1127–40.

    Article  PubMed  Google Scholar 

  27. Cooper ML, Frone MR, Russell M, Mudar P. Drinking to regulate positive and negative emotions: a motivational model of alcohol use. J Pers Soc Psychol. 1995;69(5):990–1005.

    Article  CAS  PubMed  Google Scholar 

  28. Harford TC, Yi HY, Hilton ME. Alcohol abuse and dependence in college and noncollege samples: a ten-year prospective follow-up in a national survey. J Stud Alcohol Drugs. 2006;67(6):803–9.

    Article  Google Scholar 

  29. White HR, Xie M, Thompson W, Loeber R, Stouthamer-Loeber M. Psychopathology as a predictor of adolescent drug use trajectories. Psychol Addict Behav. 2001;15(3):210–8.

    Article  CAS  PubMed  Google Scholar 

  30. Thomasson HR. Gender differences in alcohol metabolism. Recent Dev Alcohol. 1995;12:163–79.

    CAS  PubMed  Google Scholar 

  31. Weitzman ER. Poor mental health, depression, and associations with alcohol consumption, harm, and abuse in a national sample of young adults in college. J Nerv Ment Dis. 2004;192(4):269–77.

    Article  PubMed  Google Scholar 

  32. Wade TJ, Cairney J, Pevalin DJ. Emergence of gender differences in depression during adolescence: national panel results from three countries. J Am Acad Child Adolesc Psychiatry. 2002;41(2):190–8.

    Article  PubMed  Google Scholar 

  33. Edwards A, Heron J, Dick D, Hickman M, Lewis G, Macleod J, et al. Adolescent alcohol use is positively associated with later depression in a population-based U.K. Cohort. J Stud Alcohol Drugs. 2014;75(5):758–65.

    Article  PubMed Central  PubMed  Google Scholar 

  34. Edwards AC, Joinson C, Dick DM, Kendler KS, Macleod J, Munafò M, et al. The association between depressive symptoms from early to late adolescence and later use and harmful use of alcohol. Eur Child Adolesc Psychiatry. 2014;23(12):1219–30. Longitudinal study on direction of the association between MDD and AUD.

    Article  PubMed Central  PubMed  Google Scholar 

  35. Brière F, Rohde P, Seeley J, Klein D, Lewinsohn P. Comorbidity between major depression and alcohol use disorder from adolescence to adulthood. Compr Psychiatry. 2014;55(3):526–33.

    Article  PubMed Central  PubMed  Google Scholar 

  36. Rohde P, Lewinsohn PM, Kahler CW, Seeley JR, Brown RA. Natural course of alcohol use disorders from adolescence to young adulthood. J Am Acad Child Adolesc Psychiatry. 2001;40(1):83–90.

    Article  CAS  PubMed  Google Scholar 

  37. Fergusson D, Boden J, Horwood L. Alcohol misuse and psychosocial outcomes in young adulthood: results from a longitudinal birth cohort studied to age 30. Drug Alcohol Depend. 2013;133(2):513–9. Longitudinal study outlining an association between alcohol misuse and MDD in youth.

    Article  PubMed  Google Scholar 

  38. Mason W, Kosterman R, Haggerty K, Hawkins J, Redmond C, Spoth R, et al. Dimensions of adolescent alcohol involvement as predictors of young-adult major depression. J Stud Alcohol Drugs. 2008;69(2):275–85.

    Article  PubMed Central  PubMed  Google Scholar 

  39. Hill K, White H, Chung I, Hawkins J, Catalano R. Early adult outcomes of adolescent binge drinking: person- and variable-centered analyses of binge drinking trajectories. Alcohol Clin Exp Res. 2000;24(6):892–901.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  40. Cairns KE, Yap MB, Pilkington PD, Jorm AF. Risk and protective factors for depression that adolescents can modify: a systematic review and meta-analysis of longitudinal studies. J Affect Disord. 2014;169:61–75. Meta-analyses including information on the association between alcohol use and depressive symptoms.

    Article  PubMed  Google Scholar 

  41. Repetto P, Zimmerman M, Caldwell C. A longitudinal study of the relationship between depressive symptoms and alcohol use in a sample of inner-city black youth. J Stud Alcohol. 2004;65(2):169–78.

    Article  PubMed  Google Scholar 

  42. Crum R, Green K, Storr C, Chan Y, Ialongo N, Stuart E, et al. Depressed mood in childhood and subsequent alcohol use through adolescence and young adulthood. Arch Gen Psychiatry. 2008;65(6):702.

    Article  PubMed Central  PubMed  Google Scholar 

  43. Owens T, Shippee N, Hensel D. Emotional distress, drinking, and academic achievement across the adolescent life course. J Youth Adolesc. 2008;37(10):1242–56.

    Article  PubMed Central  PubMed  Google Scholar 

  44. White AM, Kraus CL, Swartzwelder HS. Many college freshmen drink at levels far beyond the binge threshold. Alcohol Clin Exp Res. 2006;30(6):1006–10.

    Article  PubMed  Google Scholar 

  45. Fleming C, Mason W, Mazza J, Abbott R, Catalano R. Latent growth modeling of the relationship between depressive symptoms and substance use during adolescence. Psychol Addict Behav. 2008;22(2):186–97.

    Article  PubMed  Google Scholar 

  46. Poulin C, Hand D, Boudreau B, Santor D. Gender differences in the association between substance use and elevated depressive symptoms in a general adolescent population. Addiction. 2005;100(4):525–35.

    Article  PubMed  Google Scholar 

  47. Schwinn T, Schinke S, Trent D. Substance use among late adolescent urban youths: mental health and gender influences. Addict Behav. 2010;35(1):30–4.

    Article  PubMed Central  PubMed  Google Scholar 

  48. Dawson D, Grant B, Stinson F, Chou P. Psychopathology associated with drinking and alcohol use disorders in the college and general adult populations. Drug Alcohol Depend. 2005;77(2):139–50.

    Article  PubMed  Google Scholar 

  49. McCarty CA, Kosterman R, Mason WA, McCauley E, Hawkins JD, Herrenkohl TI, et al. Longitudinal associations among depression, obesity and alcohol use disorders in young adulthood. Gen Hosp Psychiatry. 2009;31(5):442–50.

    Article  PubMed Central  PubMed  Google Scholar 

  50. Cranford J, Eisenberg D, Serras A. Substance use behaviors, mental health problems, and use of mental health services in a probability sample of college students. Addict Behav. 2009;34(2):134–45.

    Article  PubMed  Google Scholar 

  51. Valentiner D, Mounts N, Deacon B. Panic attacks, depression and anxiety symptoms, and substance use behaviors during late adolescence. J Anxiety Disord. 2004;18(5):573–85.

    Article  PubMed  Google Scholar 

  52. Dvorak R, Lamis D, Malone P. Alcohol use, depressive symptoms, and impulsivity as risk factors for suicide proneness among college students. J Affect Disord. 2013;149(1–3):326–34.

    Article  PubMed Central  PubMed  Google Scholar 

  53. Pedrelli P, Farabaugh A, Zisook S, Tucker D, Rooney K, Katz J, et al. Gender, depressive symptoms and patterns of alcohol use among college students. Psychopathology. 2011;44(1):27–33.

    Article  PubMed  Google Scholar 

  54. Lamis D, Malone P, Langhinrichsen-Rohling J, Ellis T. Body investment, depression, and alcohol use as risk factors for suicide proneness in college students. Crisis. 2010;31(3):118–27.

    Article  PubMed Central  PubMed  Google Scholar 

  55. Gonzalez V, Reynolds B, Skewes M. Role of impulsivity in the relationship between depression and alcohol problems among emerging adult college drinkers. Exp Clin Psychopharmacol. 2011;19(4):303–13.

    Article  PubMed  Google Scholar 

  56. Kenney S, Lac A, LaBrie J, Hummer J, Pham A. Mental health, sleep quality, drinking motives, and alcohol-related consequences: a path-analytic model. J Stud Alcohol Drugs. 2013;74(6):841–51.

    Article  PubMed Central  PubMed  Google Scholar 

  57. Vickers K, Patten C, Bronars C, Lane K, Stevens S, Croghan I, et al. Binge drinking in female college students: the association of physical activity, weight concern, and depressive symptoms. J Am Coll Heal. 2004;53(3):133–40.

    Article  Google Scholar 

  58. Owens T, Shippee N. Depressed mood and drinking occasions across high school: comparing the reciprocal causal structures of a panel of boys and girls. J Adolesc. 2009;32(4):763–80.

    Article  PubMed Central  PubMed  Google Scholar 

  59. Babor TF, de la Fuente JR, Saunders J, Grant M. AUDIT: the alcohol use disorders identification test. Guidelines for use in primary health care. Geneva: World Health Organization; 1992.

    Google Scholar 

  60. Falk D, Yi HY, Hiller-Sturmhöfel S. An epidemiologic analysis of co-occurring alcohol and drug use and disorders: findings from the National Epidemiologic Survey of Alcohol and Related Conditions (NESARC). Alcohol Res Health. 2008;31(2):100–10.

    PubMed Central  PubMed  Google Scholar 

  61. Fergusson DM, Boden JM, Horwood LJ. Tests of causal links between alcohol abuse or dependence and major depression. Arch Gen Psychiatry. 2009;66(3):260–6.

    Article  PubMed  Google Scholar 

  62. Deykin E, Levy J, Wells V. Adolescent depression, alcohol and drug abuse. Am J Public Health. 1987;77(2):178–82.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  63. Mushquash A, Stewart S, Sherry S, Sherry D, Mushquash C, MacKinnon A. Depressive symptoms are a vulnerability factor for heavy episodic drinking: a short-term, four-wave longitudinal study of undergraduate women. Addict Behav. 2013;38(5):2180–6.

    Article  PubMed  Google Scholar 

  64. Schöne C, Tandler SS, Stiensmeier-Pelster J. Contingent self-esteem and vulnerability to depression: academic contingent self-esteem predicts depressive symptoms in students. Front Psychol. 2015;20(6):1573.

    Google Scholar 

  65. Salom CL, Kelly AB, Alati R, Williams GM, Patton GC, Williams JW. Individual, school-related and family characteristics distinguish co-occurrence of drinking and depressive symptoms in very young adolescents. Drug Alcohol Rev. 2015.

  66. Rao U, Hammen CL, Poland RE. Mechanisms underlying the comorbidity between depressive and addictive disorders in adolescents: interactions between stress and HPA activity. Am J Psychiatry. 2009;166(3):361–9.

    Article  PubMed Central  PubMed  Google Scholar 

  67. Lisdahl KM, Gilbart ER, Wright NE, Shollenbarger S. Dare to delay? The impacts of adolescent alcohol and marijuana use onset on cognition, brain structure, and function. Front Psychol. 2013;1(4):53.

    Google Scholar 

  68. Demir B, Ulug B, Lay Ergun E, Erbas B. Regional cerebral blood flow and neuropsychological functioning in early and late onset alcoholism. Psychiatry Res. 2002;115:115–25.

    Article  PubMed  Google Scholar 

  69. Jacobus J, Tapert SF. Neurotoxic effects of alcohol in adolescence. Annu Rev Clin Psychol. 2013;9:703–21.

    Article  PubMed  Google Scholar 

  70. Squeglia LM, Tapert SF, Sullivan EV, Jacobus J, Meloy MJ, Rohlfing T, et al. Brain development in heavy-drinking adolescents. Am J Psychiatry. 2015;172(6):531–42.

    Article  PubMed Central  PubMed  Google Scholar 

  71. Khantzian EJ. The self-medication hypothesis revisited: the dually diagnosed patient. Primary Psychiatry. 2003;10(9):47–54.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Paola Pedrelli.

Ethics declarations

Grant Support

This study was supported by grants from the National Institute on Alcohol Abuse and Alcoholism (K23AA020064) to P. Pedrelli.

Conflict of Interest

Paola Pedrelli, Ben Shapero, Abigail Archibald, and Chelsea Dale declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

This article is part of the Topical Collection on Alcohol

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Pedrelli, P., Shapero, B., Archibald, A. et al. Alcohol use and Depression During Adolescence and Young Adulthood: a Summary and Interpretation of Mixed Findings. Curr Addict Rep 3, 91–97 (2016). https://doi.org/10.1007/s40429-016-0084-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40429-016-0084-0

Keywords

Navigation