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First Trimester CD93 as a Novel Marker of Preeclampsia and Its Complications: A Pilot Study

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Abstract

Introduction

CD93 plays a crucial role in endothelial homeostasis and angiogenesis. Recently its role in hypertension has been investigated, holding promise for novel targeted diagnostic and therapeutic strategies.

Aim

We assessed for the first time differences in first trimester serum CD93 levels in women who lately developed preeclampsia (PE) vs. normotensive pregnancy (NP).

Methods

First trimester serum CD93 concentrations were assessed in a multicenter cohort of 83 women (34 PE and 49 NP) by ELISA Immunoassay.

Results

Serum CD93 was lower in women who developed PE vs. NP (111.8 ± 24.4 vs. 137.5 ± 22.3 ng/ml; p < 0.001). Serum CD93 was associated with a decreased risk of developing PE (OR 0.950, 95% CI 0.922-0.978) and composite neonatal outcome (OR 0.952, CI 0.923-0.982), after adjustment for confounders.

Conclusions

PE is accompanied by decreased serum CD93 levels. CD93 might play a role during placentation leading to defective angiogenesis, vascular dysfunction, and PE development.

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Author information

Author notes

  1. Federica Piani and Giovanni Tossetta have contributed equally as co-first authors.

  2. Daniela Marzioni and Claudio Borghi have contributed equally as co-senior authors.

Authors and Affiliations

  1. Hypertension and Cardiovascular Risk Research Center, Medical and Surgical Sciences Department, Alma Mater Studiorum University of Bologna, Bologna, Italy

    Federica Piani & Claudio Borghi

  2. Cardiovascular Medicine Unit, Heart, Chest and Vascular Deptartment, IRCCS Azienda-Ospedaliero Universitaria Di Bologna, Bologna, Italy

    Federica Piani & Claudio Borghi

  3. Department of Experimental and Clinical Medicine, Università Politecnica delle Marche, Ancona, Italy

    Giovanni Tossetta, Sonia Fantone & Daniela Marzioni

  4. Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy

    Chiara Agostinis

  5. Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20072, Milan, Italy

    Nicoletta Di Simone

  6. IRCCS Humanitas Research Hospital, Via Manzoni 56; Rozzano, 20089, Milan, Italy

    Nicoletta Di Simone

  7. Department of Biology, Ecology and Earth Science, University of Calabria, Rende, Italy

    Maurizio Mandalà

  8. Department of Life Sciences, University of Trieste, Trieste, Italy

    Roberta Bulla

Authors
  1. Federica Piani
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  2. Giovanni Tossetta
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  3. Sonia Fantone
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  4. Chiara Agostinis
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  5. Nicoletta Di Simone
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  6. Maurizio Mandalà
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  7. Roberta Bulla
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  8. Daniela Marzioni
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  9. Claudio Borghi
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Corresponding author

Correspondence to Federica Piani.

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The authors declare no competing interests regarding this work.

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Piani, F., Tossetta, G., Fantone, S. et al. First Trimester CD93 as a Novel Marker of Preeclampsia and Its Complications: A Pilot Study. High Blood Press Cardiovasc Prev 30, 591–594 (2023). https://doi.org/10.1007/s40292-023-00608-y

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  • DOI: https://doi.org/10.1007/s40292-023-00608-y

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