Skip to main content
SpringerLink
Log in

Food Consumption is Associated with Hyperuricemia in Boys

  • Original article
  • Published:
High Blood Pressure & Cardiovascular Prevention Aims and scope Submit manuscript

Abstract

Introduction

Hyperuricemia is related to health issues among children and adolescents, once the uric acid concentration is associated with metabolic syndrome, hypertension, insulin resistance, obesity, and dyslipidemia. However, few studies are addressing uric acid levels and food uptake in this age group.

Aim

To verify the association between food consumption and uric acid in children and adolescents.

Methods

This is a cross-sectional study developed with 2335 children and adolescents of both genders aged 6–17 years old. Blood collection was performed after 12 h of fasting. Uric acid values were classified according to tertiles, in which the highest tertile was considered as hyperuricemia. Food consumption was evaluated by weekly consumption frequency questionnaire. Pearson correlation and logistic binary regressions were used for statistical analysis. Models were adjusted for age, systolic blood pressure, body mass index (BMI), and skin color/ethnicity.

Results

It was found an association between red meat consumption and hyperuricemia only in boys in the crude model (OR = 1.56; 95% CI 1.12; 2.18). Also, there was an association between pasta (OR = 1.52; 95% CI 1.11; 2.10) with hyperuricemia in boys, when adjusted age, systolic blood pressure, BMI, and skin color/ethnicity.

Conclusion

The knowledge of food patterns which are predisposing factors for the increase in serum uric acid levels is important for the implementation of strategies and public health policies for health promotion among children and adolescents.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Data availability

The dataset analyzed during the current study is available from the corresponding author on a reasonable request.

References

  1. Ford ES, Choi HK. Associations between concentrations of uric acid with concentrations of vitamin A and beta-carotene among adults in the United States. Nutr Res. 2013;33(12):995–1002. https://doi.org/10.1016/j.nutres.2013.08.008.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Schmidt JA, Crowe FL, Appleby PN, Key TJ, Travis RC. Serum uric acid concentrations in meat eaters, fish eaters, vegetarians and vegans: a cross-sectional analysis in the EPIC-Oxford cohort. PLoS ONE. 2013;8(2):e56339. https://doi.org/10.1371/journal.pone.0056339.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Liu D, Jiang L, Gan L, Su Y, Li F. Association between serum uric acid level and body mass index in sex—and age-specific groups in southwestern China. Endocr Pract. 2019;25(5):438–45. https://doi.org/10.4158/EP-2018-0426.

    Article  PubMed  Google Scholar 

  4. Batt C, Phipps-Green AJ, Black MA, Cadzow M, Merriman ME, Topless R, et al. Sugar-sweetened beverage consumption: a risk factor for prevalent gout with SLC2A9 genotype-specific effects on serum urate and risk of gout. Ann Rheum Dis. 2014;73(12):2101–6. https://doi.org/10.1136/annrheumdis-2013-203600.

    Article  PubMed  Google Scholar 

  5. Genoni G, Menegon V, Secco GG, Sonzini M, Martelli M, Castagno M, et al. Insulin resistance, serum uric acid and metabolic syndrome are linked to cardiovascular dysfunction in pediatric obesity. Int J Cardiol. 2017;249:366–71. https://doi.org/10.1016/j.ijcard.2017.09.031.

    Article  PubMed  Google Scholar 

  6. Liu Z, Chen T, Niu H, Ren W, Li X, Cui L, et al. The establishment and characteristics of rat model of atherosclerosis induced by hyperuricemia. Stem Cells Int. 2016;2016:1–7. https://doi.org/10.1155/2016/1365257.

    Article  CAS  Google Scholar 

  7. Falsetti P, Acciai C. Oral vitamin C supplementation and serum uric acid: Comment on the article by Juraschek et al. Arthritis Care Res. 2012;64(6):941–4. https://doi.org/10.1002/acr.21614.

    Article  Google Scholar 

  8. Tsai Y-T, Liu J-P, Tu Y-K, Lee M-S, Chen P-R, Hsu H-C, et al. Relationship between dietary patterns and serum uric acid concentrations among ethnic Chinese adults in Taiwan. Asia Pac J Clin Nutr. 2012;21(2):263–70.

    CAS  PubMed  Google Scholar 

  9. Zykova SN, Storhaug HM, Toft I, Chadban SJ, Jenssen TG, White SL. Cross-sectional analysis of nutrition and serum uric acid in two Caucasian cohorts: the AusDiab Study and the Tromsø study. Nutr J. 2015;14(1):1–11. https://doi.org/10.1186/s12937-015-0032-1.

    Article  CAS  Google Scholar 

  10. Jia G, Aroor AR, Whaley-Connell AT, Sowers JR. Fructose and uric acid: is there a role in endothelial function? Curr Hypertens Rep. 2014;16(6):434. https://doi.org/10.1007/s11906-014-0434-z.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Nguyen S, Choi HK, Lustig RH, Hsu C. Sugar-sweetened beverages, serum uric acid, and blood pressure in adolescents. J Pediatr. 2009;154(6):807–13. https://doi.org/10.1016/j.jpeds.2009.01.015.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Mosca A, Nobili V, De Vito R, Crudele A, Scorletti E, Villani A, et al. Serum uric acid concentrations and fructose consumption are independently associated with NASH in children and adolescents. J Hepatol. 2017;66(5):1031–6. https://doi.org/10.1016/j.jhep.2016.12.025.

    Article  CAS  PubMed  Google Scholar 

  13. Zhao Y, Yu Y, Li H, Li M, Zhang D, Guo D, et al. The association between metabolic syndrome and biochemical markers in beijing adolescents. Int J Environ Res Public Health. 2019;16(22):1–10. https://doi.org/10.3390/ijerph16224557.

    Article  CAS  Google Scholar 

  14. Kubota M. Hyperuricemia in children and adolescents: present knowledge and future directions. J Nutr Metab. 2019. https://doi.org/10.1155/2019/3480718.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Hyun LJ. Prevalence of hyperuricemia and its association with metabolic syndrome and cardiometabolic risk factors in korean children and adolescents: analysis based on the 2016–2017 korea national health and nutrition examination survey. Korean J Pediatr. 2019;62(8):317–23. https://doi.org/10.3345/kjp.2019.00444.

    Article  Google Scholar 

  16. Mariz L, Medeiros C, Vieira C, Enders B, Coura A. Modificação na frequência alimentar de crianças e adolescentes: acompanhamento em serviço de referência. Revista Latino-Americana de Enfermagem. 2013;21(4):973–81. https://doi.org/10.1590/S0104-11692013000400020.

    Article  PubMed  Google Scholar 

  17. Ramayani ORE. Childhood hyperuricemia as risk factor of hypertension in adulthood. Indones Biomed J. 2012;4(1):12. https://doi.org/10.18585/inabj.v4i1.156.

    Article  Google Scholar 

  18. Brasil. Agenda Nacional de Prioridades de Pesquisa em Saúde. 2. ed., 4. Brasília: Editora do Ministério da Saúde; 2015, p 68.

  19. Barros MVG, Nahas M V. Medidas de Atividade Física: Teoria e Aplicação em Diversos Grupos Populacionais. Tópicos em Atividade Física e Saúde. 2003. p. 160.

  20. Suttikomin W, Leelahagul P, Khamvang S, Chaimongkol C, Chaiwut N. Obesity and serum uric acid in secondary school-age students of srinagarindra the princess mother school, Phayao, Thailand. Indian J Public Health. 2018;62(2):133–7. https://doi.org/10.4103/ijph.IJPH_117_17.

    Article  PubMed  Google Scholar 

  21. Feig DI, Johnson RJ. Hyperuricemia in childhood primary hypertension. Hypertension. 2003;42(3):247–52. https://doi.org/10.1161/01.HYP.0000085858.66548.59.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Desideri G, Virdis A, Casiglia E, Borghi C, Cicero AFG, Muiesan ML, et al. Exploration into uric and cardiovascular disease: uric acid right for heArt Health (URRAH) Project, a study protocol for a retrospective observational study. High Blood Press Cardiovasc Prev. 2018;25(2):197–202. https://doi.org/10.1007/s40292-018-0250-7.

    Article  CAS  PubMed  Google Scholar 

  23. Heidemann C, Scheidt-Nave C, Richter A, Mensink GBM. Dietary patterns are associated with cardiometabolic risk factors in a representative study population of German adults. Br J Nutr. 2011;106(8):1253–62. https://doi.org/10.1017/S0007114511001504.

    Article  CAS  PubMed  Google Scholar 

  24. Li X, Song P, Li J, Wang P, Li G. Relationship between hyperuricemia and dietary risk factors in Chinese adults: a cross-sectional study. Rheumatol Int. 2015;35(12):2079–89. https://doi.org/10.1007/s00296-015-3315-0.

    Article  CAS  PubMed  Google Scholar 

  25. Stöckl D, Döring A, Thorand B, Heier M, Belcredi P, Meisinger C. Reproductive factors and serum uric acid levels in females from the general population: the KORA F4 study. PLoS ONE. 2012;7(3):e32668. https://doi.org/10.1371/journal.pone.0032668.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Kolz M, Johnson T, Sanna S, Teumer A, Vitart V, Perola M, et al. Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet. 2009. https://doi.org/10.1371/journal.pgen.1000504.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Redon P, Maloberti A, Facchetti R, Redon J, Lurbe E, Bombelli M, et al. Gender-related differences in serum uric acid in treated hypertensive patients from central and east European countries: findings from the blood pressure control rate and cardiovascular risk profile study. J Hypertens. 2019;37(2):380–8. https://doi.org/10.1097/HJH.0000000000001908.

    Article  CAS  PubMed  Google Scholar 

  28. Maloberti A, Maggioni S, Occhi L, Triglione N, Panzeri F, Nava S, et al. Sex-related relationships between uric acid and target organ damage in hypertension. J Clin Hypertens. 2018;20(1):193–200. https://doi.org/10.1111/jch.13136.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We acknowledge the National Council for Scientific and Technological Development (CNPq) and Coordination for the Improvement of Higher Education Personnel (CAPES), for the granting of a scholarship that made this work possible.

Author information

Authors and Affiliations

  1. Graduate Program in Human Movement Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

    Luiza Naujorks Reis, Leticia Borfe & Anelise Reis Gaya

  2. Graduate Program in Health Promotion, University of Santa Cruz do Sul, Santa Cruz do Sul, Rio Grande do Sul, Brazil

    Caroline Brand, Silvia Isabel Rech Franke, Jane Dagmar Pollo Renner & Cézane Priscila Reuter

  3. Centro Universitario Regional Noreste, Universidad de la República, Rivera, Uruguay

    Javier Brazo-Sayavera

Authors
  1. Luiza Naujorks Reis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Leticia Borfe
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Caroline Brand
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Silvia Isabel Rech Franke
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jane Dagmar Pollo Renner
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Anelise Reis Gaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Javier Brazo-Sayavera
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Cézane Priscila Reuter
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

LNR and CPR conceptualized and designed the study. LNR, LB, CB, and CPR acquired the data, carried out the analyses, interpreted the data, and drafted the article. CB, SIRF, JDPR, ARG, and JBS critically reviewed the article. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Cézane Priscila Reuter.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Consent to participate

Informed consent was obtained from all individual participants included in the study.

Ethics approval

This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of University Santa Cruz do Sul (July 10, 2014).

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Reis, L.N., Borfe, L., Brand, C. et al. Food Consumption is Associated with Hyperuricemia in Boys. High Blood Press Cardiovasc Prev 27, 409–415 (2020). https://doi.org/10.1007/s40292-020-00406-w

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40292-020-00406-w

Keywords

Search

Navigation