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Drug Treatment of Heart Failure in Children: Gaps and Opportunities

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Abstract

Medical therapy for pediatric heart failure is based on a detailed mechanistic understanding of the underlying causes, which are diverse and unlike those encountered in most adult patients. Diuresis and improved perfusion are the immediate goals of care in the child with acute decompensated heart failure. Conversion to maintenance oral therapy for heart failure is based on the results of landmark studies in adults, as well as recent pediatric clinical trials and heart failure guidelines. There will continue to be an important role for newer drugs, some of which are in active trials in adults, and some of which are already approved for use in children. The need to plan for clinical trials in children during drug development for heart failure is emphasized.

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Authors and Affiliations

  1. Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

    Molly Weisert, Jennifer A. Su, Jondavid Menteer, Robert E. Shaddy & Paul F. Kantor

  2. Division of Cardiology, Heart Institute, Children’s Hospital Los Angeles, Los Angeles, CA, USA

    Molly Weisert, Jennifer A. Su, Jondavid Menteer, Robert E. Shaddy & Paul F. Kantor

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Robert Shaddy and Paul Kantor have served as Consultants to Novartis. Molly Weisert, Jennifer Su, and Jondavid Menteer declare no potential conflicts of interest that might be relevant to this manuscript.

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Weisert, M., Su, J.A., Menteer, J. et al. Drug Treatment of Heart Failure in Children: Gaps and Opportunities. Pediatr Drugs 24, 121–136 (2022). https://doi.org/10.1007/s40272-021-00485-9

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