FormalPara Key Points

Microscopic colitis is a prevalent condition among older adults above the age of 60 years.

Patients suspected with long-standing or recurrent non-bloody watery diarrhea should always be referred for colonoscopy with three biopsies from right and left colon followed by extensive histopathological evaluations.

Oral budesonide is the drug of choice for microscopic colitis, but nonsteroidal medications, including bismuth subsalicylate, biologics, bile acid sequestrants, and supportive antidiarrheal drugs followed by thiopurines, may be useful alternatives.

1 Introduction

Microscopic colitis, a chronic disorder of unknown etiology with a female preponderance, is a common but treatable cause of recurrent non-bloody watery diarrhea. The diarrhea, together with symptoms such as abdominal cramps, urgency, and fecal incontinence, can have a significant negative impact on quality of life and social function. The disease has been reported to have an increasing incidence, and its incidence may, in some geographical areas, exceed those of ulcerative colitis and Crohn’s disease among elderly individuals [1]. Microscopic colitis is associated with ulcerative colitis and Crohn’s disease in the umbrella diagnosis of inflammatory bowel disease (IBD) [1]. Microscopic colitis is named so because specific histological changes are identified under a microscope, whereas an endoscopic examination of the colon is usually macroscopically normal, although endoscopic findings such as ulceration of vascular mucosal pattern, a “furrowed” or “mosaic” pattern, mucosal erythema, edema, nodularity, or mucosal defects, including “cat scratches,” have been reported [2,3,4], which are, however, not pathognomonic. There are two major histological subtypes of microscopic colitis: collagenous and lymphocytic colitis, although incomplete forms exist [5]. The distinction between subtypes does not influence management decisions or prognosis. Due to the lack of reliable biomarkers, colonoscopy with random biopsies is always required to reach a diagnosis. Consequently, healthcare providers should be familiar with the clinical features and the most rational management of the older adults.

For the management of microscopic colitis, a treatment course with oral budesonide 9 mg/day for 6–8 weeks is considered first-line therapy [6,7,8]. However, patients often experience relapse when budesonide is withdrawn, and some patients may become intolerant, dependent, or even fail to respond. Accordingly, alternative therapeutics, including bismuth subsalicylate, biologics, bile acid sequestrants, and thiopurines, may be indicated to control the symptoms and enhance the quality of life of patients affected by this debilitating chronic disease, as recommended by international guidelines [9,10,11]. Loperamide is not included in all recommendations, but this drug is widely used for management of microscopic colitis, alone or in combination with other therapies, even though no formal, well-powered trials have been performed. Regarding the prognosis, recent data from a 5 year prospective European cohort of patients with microscopic colitis has shown that 40% had a relapsing or chronic active disease course, and that disease activity after 1 year seems to be predictive of the subsequent disease course [12].

The aim of this review is to provide the reader updated information about the diagnosis of microscopic colitis and rational management, with alternative treatment options for elderly patients not responding sufficiently to first-choice budesonide therapy.

2 Epidemiology

The incidence and prevalence of microscopic colitis have increased over time, emphasizing the importance of recognizing and diagnosing it in the clinic [13]. In Denmark, the overall incidence of microscopic colitis increased from 2.3 cases in 2001 to 24.3 per 100,000 patient years in 2016 (with a mean age at diagnosis of 65 years) [14], and similarly, in Switzerland, the incidence rose from 0.36 per 100,000 patient years in 1994–1997 to 6.85 in 2017, with a mean age of 63 years at diagnosis [15]. Comparable trends have been observed in the USA [16], although with subsequent stabilization of incidence [17]. In this context, it should be noted that epidemiological studies have proven that the incidence of microscopic colitis exceeds those of ulcerative colitis and Crohn’s disease in individuals aged ≥ 60 years. Thus, using nationwide health registries in Denmark, the above-mentioned incidence of microscopic colitis of 24.3 per 100,000 patient years in 2016 should be compared with 18.6 for ulcerative colitis and 9.1 Crohn’s disease per 100,000 patient years in 2013 [14, 18].

Various factors, including improved awareness of this condition among gastroenterologists and pathologists, as well as varying occurrence of risk factors (e.g., cigarette smoking, medications, intestinal infections, female sex, and concomitant diseases) at various geographical locations [1, 19, 20], may influence differences in its incidence, as a substantial difference among geographical regions has been observed [1]. Based on a recent meta-analysis, predominantly from data originating from North America and Europe, pooled worldwide incidences of the subtypes collagenous and lymphocytic colitis were 4.9 [95% confidence interval (CI) 4.2–5.7] and 5.0 [95% CI 4.0–6.1] cases, respectively, per 100,000 patient years [9].

3 Symptoms

The symptoms of microscopic colitis are nonspecific and may mimic those of irritable bowel syndrome [21,22,23], and as histology is required, the diagnosis might easily be overlooked in clinical settings [24]. The disease is characterized by a clinicopathological triad of (1) a history of chronic (i.e., for more than 4 weeks) or recurrent/intermittent non-bloody watery diarrhea, (2) a normal or almost normal colonoscopy, and (3) a distinct histological pattern in colonic biopsy specimens when examined under a microscope [1]. Apart from non-bloody watery diarrhea, which is often a key symptom in the early hours, other symptoms include urgency, fecal incontinence, fatigue, abdominal cramps or bloating, weight loss, arthralgia related to disease flares, and impaired quality of life. However, increased incidences of bile salt diarrhea [25] and celiac disease [26, 27] are associated with microscopic colitis [21]. Therefore, celiac disease should be excluded in all individuals suspected of microscopic colitis. Moreover, bile acid induced diarrhea should always be considered in those not responding properly to budesonide with continued diarrhea.

The pathogenesis of microscopic colitis is complex and multifactorial, and involves innate and adaptive immune responses to luminal antigens, genetic risk factors, and autoimmunity, as well as extracellular matrix alterations, all of which contribute by varied mechanisms to watery diarrhea [28, 29]. Moreover, similar symptoms and histologic findings may develop following therapy with checkpoint inhibitors, a therapeutic option that is increasingly used for a broad variety of oncological and hematological diseases also in older adults [30,31,32].

4 Diagnosis

The diagnosis of microscopic colitis is based on a combination of the clinical presentation and histological changes. Therefore, all patients with chronic or recurrent non-bloody watery diarrhea should undergo colonoscopy with biopsies (Fig. 1). Thus, histological examinations are key for reaching a diagnosis, as the endoscopic findings may be normal, unlike the characteristics for flares of ulcerative colitis or Crohn’s disease.

Fig. 1
figure 1

Graphical flow chart indicating the approach to diagnosis and management of microscopic colitis

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Controversy exists regarding where and how many biopsy specimens should be obtained at the time of colonoscopy. According to the American Society for Gastrointestinal Endoscopy (ASGE), two or more biopsies are suggested from each of the following locations: the right, transverse, descending, and sigmoid colons during colonoscopy; or two or more biopsies should be obtained from the transverse, sigmoid, and descending colons if flexible sigmoidoscopy is performed [33]. However, the various available guidelines are not evidence based, rely on expert opinions, and have not been prospectively validated. A recent systematic review of the optimum number of colon biopsies for diagnosing microscopic colitis recommended a minimum of six biopsies to be taken from the ascending and descending colons (three from each part) [34].Thus, a combination of clinical symptoms (watery diarrhea, urgency, and often bloating) and histological findings are needed to reach the diagnosis of microscopic colitis.

5 Pathology

Histological examination distinguishes collagenous and lymphocytic colitis. The collagenous form was originally described by Lindström et al. in 1976 [35], and the term microscopic colitis was introduced by Read et al. in 1980 [36], and in 1989, Lazenby et al. [37] introduced the term lymphocytic colitis. Although histologic findings are not pathognomonic or verified, they do help the pathologist reach the histological diagnosis when paired with the appropriate clinical context.

Nonetheless, in addition to the widely accepted histological criteria, an additional subtype with less prominent histological findings on hematoxylin–eosin (HE) stained specimens, known as incomplete microscopic colitis or microscopic colitis not otherwise specified, exists [38], and some patients with this condition may respond to treatment used for microscopic colitis [39] (Table 1). Due to the fact that incomplete microscopic colitis or microscopic colitis not otherwise specified exists, in clinical settings, a lower threshold should be considered in relation to the definition of the distinctive findings on a colonic biopsy in collagenous colitis, which is defined as a thickened subepithelial collagen band (> 10 µm, compared with normal ≤ 5 µm) [40], although a less prominent intraepithelial lymphocyte (IEL) infiltrate may be observed [1] (Table 1). In lymphocytic colitis, more pronounced IEL, defined as more than 20 IEL per 100 surface epithelial cells, combined with an increased inflammatory infiltrate in the lamina propria and a nonsignificantly thickened collagenous band, is a distinct feature [1] (Table 1). Additionally, a mixed infiltrate of acute and chronic inflammatory cells appears in the lamina propria during lymphocytic colitis. In collagenous colitis, inflammation of the lamina propria may be less prominent, but surface epithelial damage tends to be more pronounced than that in lymphocytic colitis. Biopsies frequently contain a neutrophilic infiltrate, even with active cryptitis [41], but acute inflammation should not predominate [1].

Table 1 Key histological findings in microscopic colitis: Differences between collagenous, lymphocytic, and incomplete microscopic colitis are shown
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However, a correct diagnosis is crucial for the appropriate treatment of microscopic colitis and for differentiating this condition from other conditions with similar symptoms [25, 42].

6 Medications that Trigger Microscopic Colitis

Although the etiology of microscopic colitis has not yet been clarified, autoimmune diseases and medications may trigger an imbalanced mucosal immune response in the colon of genetically predisposed individuals, which may aid in the emergence of microscopic colitis [1, 29]. Thus, microscopic mucosal inflammation is likely to be the cause of the diarrhea that accompanies microscopic colitis [1].

Examples of culprit medications linked to microscopic colitis are as follows: nonsteroidal anti-inflammatory drugs (NSAIDs) [43, 44] including ibuprofen and diclofenac often used for a wide range of musculoskeletal conditions in elderly people [45]; proton-pump inhibitors [43, 44] such as lansoprazole and omeprazole, drugs reported to be used in more than 50% of individuals above 65 years [46]; histamine-2 receptor antagonists [47] such as ranitidine and famotidine; selective serotonin-reuptake inhibitors [43, 44] such as sertraline and citalopram; clozapine (an antagonist to dopamine type 2 and the serotonin type 2A receptors) [48]; acetylic salicylic acid [49] such as aspirin; statins [50] such as simvastatin and atorvastatin; and immune checkpoint inhibitors [1, 31] such as pembrolizumab. Therefore, healthcare providers should always review the medications of patients with symptomatic microscopic colitis to induce remission through optimized therapy. Nevertheless, in studies using patients with diarrhea as a control group, much less evidence of drug-induced microscopic colitis was found compared with those that used healthy controls [51, 52]. This raises the possibility that these medications may worsen diarrhea and bring cases to clinical attention, rather than actually causing microscopic colitis.

7 Prognosis

Although the symptoms can significantly impact quality of life, the prognosis is good, and no increased risk of colon cancer has been reported, in contrast to what has been found with other diseases under IBD [53], such as ulcerative colitis [54] and Crohn’s disease [55]. On the contrary, patients with microscopic colitis seem to have a reduced risk of colorectal cancer [56] or colonic adenoma [57] and, based on all available data, chromo-endoscopic surveillance in individuals diagnosed with microscopic colitis is not required [58]. However, a recent Swedish nationwide population-based matched cohort study revealed a 27% increased risk of major adverse cardiovascular events in microscopic colitis, which underlines the need for additional pathophysiological studies, with a focus on the mechanisms behind such complications in microscopic colitis [59]. In the interim, medical professionals should offer guidance and treatments targeted at lowering the risk of cardiovascular disease in the elderly population with this disease.

8 Clinical Studies Investigating Therapy for Microscopic Colitis

A general problem exists when assessing clinical data from various trials on the management of microscopic colitis. In contrast to clinical trials addressing the effectiveness of therapies for the two classical IBDs, i.e., ulcerative colitis and Crohn’s disease, where well-established and validated clinical indices [e.g., Harvey Bradshaw [60] and Crohn’s Disease Activity Index (CDAI) [61] for Crohn’s disease, and the Mayo score [62] or Simple Clinical Colitis Activity Index [63] for ulcerative colitis] are widely adapted, variable and not well-defined activity scores for treatment responses (e.g., stool frequency complemented by stool weight in some studies, or time to a histological response in some other studies) are used in clinical trials for microscopic colitis. Thus, validated instruments for assessing response and remission are seldom used in microscopic colitis trials. As a result, it is difficult to make firm conclusions about the comparative effectiveness of various treatment options in microscopic colitis due to the heterogeneity in definitions of treatment response.

Chande et al. [64] has previously paid attention to the need for more accurate and uniform outcome measures in clinical trials studying the effectiveness of various therapies for microscopic colitis in an effort to define the disease activity of this disease, and thus, reliable assessments of clinical response and remission. In this context, Hjortswang et al. [65] proposed clinical criteria, including bowel movements and stool consistency, where clinical remission in collagenous colitis was defined as a mean of less than three stools per day (and with less than one watery stool per day) within the previous 7 days. In a recent systematic review of 25 clinical studies dealing with microscopic colitis therapy, this definition was identified in only four of the trials [66]. This may cause marked variance when assessing and comparing data from different clinical trials of therapeutics for this condition, and head-to-head trials between different drugs are scarce. Moreover, the Hjortswang criteria were solely derived for collagenous colitis and not for lymphocytic colitis [65]. Nonetheless, patients with microscopic colitis often complain of other troublesome symptoms, including abdominal discomfort, urgency, and fecal incontinence, which impair their health-related quality of life. These other symptoms are still unaccounted for using these criteria. As no standards have been developed to define disease activity in microscopic colitis, this matter may preclude the evaluation of responsiveness to the therapies investigated, as well as any risk stratification of patients in clinical studies.

Based on the limitations described, Cotter et al. [67] aimed to identify clinical features of microscopic colitis associated with disease severity in elderly patients (median age in this study of 66 years) in an effort to create a Microscopic Colitis Disease Activity Index (MCDAI) comparable to the CDAI scores utilized to assess disease activity in clinical trials [61]. The amount of daily unformed stools, nocturnal stools, stomach pain, fecal urgency and incontinence, and weight loss are all included in the MCDAI scores [67], which is still awaiting external validation.

9 Therapy for Microscopic Colitis

9.1 First-Line Therapy with Budesonide

No therapeutic differences exist in the management of collagenous and lymphocytic colitis, and based on evidence from several clinical trials, budesonide is considered the drug of choice for the management of microscopic colitis [6,7,8], including its incomplete form [39]. Budesonide is a second-generation glucocorticoid with low systemic bioavailability due to a 80–90% first-pass hepatic metabolism [61] and with less dysfunction of the hypothalamic–pituitary–adrenal axis compared with therapeutically equivalent doses of oral prednisone [68]. Compared with other corticosteroids, budesonide has a markedly reduced incidence of systemic adverse events, with the most frequent adverse effect reported being cushingoid features and hypokalemia [69]. Moreover, adrenal insufficiency has never been reported when budesonide is discontinued without tapering after a 6–8 week induction treatment course of 9 mg daily.

Although the vast majority of patients in a population-based cohort respond to budesonide induction therapy [70], some patients may only experience a partial response, others may have no response, and some patients may even be intolerant (Fig. 2). As recurrence shortly after cessation of a treatment course is a frequent phenomenon [8, 71,72,73], budesonide may be prescribed as maintenance therapy at the lowest possible dose, for example 3 mg/day or every second day, together with calcium and vitamin D supplementation [1]. In a recent systematic review and meta-analysis of 35 studies (i.e., 11 randomized controlled trails and 24 observational studies) with 1657 patients diagnosed with microscopic colitis treated with budesonide induction therapy, the overall pooled clinical remission rate on budesonide maintenance therapy for a median duration of 39 weeks (range, 24–62 weeks) was 84% [73]. In this study, the pooled recurrence rate after the discontinuation of budesonide induction therapy was 50%, with a median time to recurrence that ranged from 2 to 61 weeks, whereas the pooled recurrence rate after discontinuation of maintenance therapy was 58%, with a median time to recurrence of 6–48 weeks [73]. In another recent population-based study, 162 patients with microscopic colitis received budesonide induction therapy, of whom 96 had recurrence after discontinuation. Of these patients, 35% continued with long-term budesonide maintenance with a median duration of follow-up of 5.6 years (0.3–18.9 years) [74]. However, the incidence of metabolic bone disease (i.e., osteopenia/osteoporosis), diabetes mellitus, hypertension, glaucoma, and cataracts, which are all predisposed comorbid conditions in elderly individuals, did not increase among those on long-term budesonide maintenance [46% (95% CI, 0.35–0.56) I2 = 0%] versus those who received induction therapy or placebo [33% (95% CI, 0.23–0.44) I2 = 79%], and none stopped long-term maintenance therapy due to adverse events [73, 74]. Nevertheless, larger, more robust prospective trials are required to fully assess the effectiveness and safety of long-term maintenance budesonide for microscopic colitis.

Fig. 2
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Proposed therapeutic algorithm to control microscopic colitis in older adults. ICI, immune checkpoint inhibitors

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9.2 Alternatives to Budesonide in the Management of Microscopic Colitis

Alternatives to budesonide with antidiarrheal or immunomodulatory drugs (including biologics), such as bismuth subsalicylate, biologics, loperamide, bile acid sequestrants, and thiopurines, may be trialed for patients with troublesome microscopic colitis (those who are intolerant or fail to respond to budesonide and those who develop marked adverse events to this therapy), or as maintenance therapy to avoid any side effects of glucocorticoids. In these circumstances a frailty check is of importance in geriatric practice when considering the various therapeutic options based on side effects in older patients (Fig. 1). In this context, prednisolone has been found to be inferior to budesonide [1, 75]; methotrexate showed effectiveness in only one study where 75% received combined budesonide, thus limiting the conclusions [76]; and mesalazine, a cornerstone in therapy of ulcerative colitis, was not been found to be superior to placebo [77, 78]. Moreover, no formal and well-powered data exist for probiotics or newer small molecules, such as Janus Kinase inhibitors, for the management of microscopic colitis.

Based on a recent systematic review and meta-analysis conducted until April 2023, alternatives to budesonide are comparable to those reported in clinical trials [66] (Table 2), as explained below.

Table 2 Response rates of alternatives to budesonide for management of microscopic colitis
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9.3 Bismuth Subsalicylate

Based on results from clinical studies, bismuth subsalicylate, a substance with antisecretory and anti-inflammatory properties, has been shown to reduce diarrhea in various diseases, including microscopic colitis [79], although its antidiarrheal mechanism is still not clarified [80]. The recommended dose of bismuth subsalicylate for microscopic colitis is nine tablets [262 mg each] per day in three divided doses. Based on a meta-analysis of seven studies with 377 participants, 75% of patients showed a response to treatment with bismuth subsalicylate (95% CI, 0.65–0.83; I2 = 70.12%), and 50% achieved remission (95% CI, 0.35–0.65; I2 = 71.06%) [66]. However, robust, prospective, placebo-controlled studies stratified by disease severity and subtype are needed to ascertain the genuine advantages of bismuth subsalicylate. That said, prolonged usage of bismuth subsalicylate is not recommended as it may increase the risk of neurotoxicity and accelerate weakness in older patients [81, 82].

9.4 Biologics

In recent years, tumor necrosis factor (TNF) inhibitors (infliximab and adalimumab), together with the α4β7 integrin inhibitor, vedolizumab, and more recently the anti-IL-12/IL-23 antibody, ustekinumab, have all been investigated in the management of microscopic colitis. A recent meta-analysis identified 22 studies that used biologics for microscopic colitis [66]. However, the majority (17/22) were case reports/series, with only four cohort studies. Only two studies reported the use of ustekinumab (an IL-12/IL-23 inhibitor), while 13 studies examined the effects of TNF inhibitors (infliximab or adalimumab), and 11 studies included patients who received vedolizumab, an anti-integrin. Because the majority of the studies had insufficient participant numbers (i.e., fewer than five participants), they did not meet the inclusion criteria. Eight of the studies, comprising 156 patients, were included in the meta-analysis [66] (89 patients on TNF inhibitors and 67 patients on anti-integrin). A response rate of 73% (95% CI, 0.63–0.83; I2 = 0.00%) and a remission rate of 44% (95% CI, 0.32–0.56; I2 = 0.00%) were recorded when using a TNF inhibitor. Using an anti-integrin, a response was found in 73% (95% CI, 0.57–0.87; I2 = 35.93%) with a remission rate of 56% (95% CI, 0.36–0.75; I2 = 46.30%). Owing to sparse data on the effectiveness of ustekinumab in microscopic colitis, more well-powered trials are still warranted. Another recent systematic review and meta-analysis of TNF inhibitors and vedolizumab in 14 studies involving 164 patients additionally identified these biologics to be of clinical benefit for the management of steroid-refractory microscopic colitis and suggested that vedolizumab may be superior to TNF inhibitors [83]. In the context of elderly patients, vedolizumab seems to have a preferred safety profile of the available biologics among these patients [84], although no head-to-head studies have been performed for microscopic colitis [85]. This observation was also noticed in a recent multicenter cohort study [86]. However, cheaper therapeutic alternatives to budesonide should be attempted first, as the expense of biologics may be a potential barrier to their widespread use in the management of microscopic colitis.

9.5 Loperamide

Loperamide, a synthetic opioid that primarily affects intestinal opiate receptors to control diarrhea [87], has been studied for microscopic colitis in seven minor studies, five of which were retrospective cohorts. In these studies with 2 mg tablets (up to eight tablets daily), a meta-analysis showed that 62% of the patients responded to loperamide therapy (95% CI, 0.43–0.80; I2 = 92.99%) [66]. For the treatment of microscopic colitis, formal, prospective, and well-powered investigations on loperamide are still required. Until then, this medication may be used as a symptomatic treatment option for elderly individuals with urgency and mild microscopic colitis, or as part of a combination therapy when symptoms do not entirely subside in response to the prescription medication, such as budesonide, although this treatment is not recommended by available guidelines.

9.6 Bile Acid Sequestrants

Cholestyramine (a bile acid-binding resin indicated to reduce diarrhea caused by bile acid malabsorption) may be used as a therapy for microscopic colitis [88] or to decrease budesonide dependence in microscopic colitis [89]. Cholestyramine is prescribed at a starting dose of 4 g once or twice per day, and subsequently increased slowly depending on the clinical response to a maximum dose of 24 g/day.

In a meta-analysis, nine studies with 408 patients were identified to examine the effects of bile acid sequestrants on microscopic colitis [66]. Overall, 60% of patients responded to this treatment (95% CI, 0.51–0.68; I2 = 61.65%) and 29% (95% CI, 0.12–0.55) achieved remission. However, in a recent study, no differences were reported in the effectiveness of bile acid sequestrants for microscopic colitis between patients with and without stool or blood tests suggesting bile acid malabsorption [88].

9.7 Thiopurines

When symptoms are refractory and considerably affect the quality of life, thiopurines (azathioprine 2–2.5 mg/kg per day or mercaptopurine 1–1.5 mg/kg per day), which are antimetabolites of purines and immunomodulators [90], may be considered for the maintenance of clinical remission as a last resort both based on effectiveness [66], but also due to the risk of complications. Thus, the risk of potential drug interactions, and the development of non-melanoma skin cancer, lymphoma, and infections need to be carefully considered before prescribing this drug to individuals above the age of 60 years [91]. Moreover, owing to the delayed onset of action of approximately 3 months, thiopurines are not ideal for induction therapy [92]. Based on five studies included in a meta-analysis for long-term therapy, an overall response rate to thiopurine exposure was reported in 49% of patients (95% CI, 0.27–0.71; I2 = 81.45%), and remission was achieved in 38% (95% CI, 0.23–0.54; I2 = 50.05%) after a median of 15 months of therapy [66]. Nonetheless, several studies have reported high rates of intolerance to these drugs, and it still remains unknown how long thiopurines should be prescribed in cases of beneficial effects. If this therapy is tolerated, patients should be monitored regularly with routine blood samples, including complete blood cell count and liver and pancreatic function tests [92].

10 Conclusions

Symptoms related to flares of chronic microscopic colitis are frequent among older adults and include non-bloody watery diarrhea, urgency, and fecal incontinence, which may easily be clinically misdiagnosed as irritable bowel syndrome due to the similarity of symptoms. However, microscopic colitis should always be taken into consideration in geriatric settings in cases of unexplained non-bloody watery diarrhea in elderly individuals aged 60 years or older.

As no biomarkers have yet been identified, patients with long-standing or recurrent watery diarrhea should be referred for colonoscopy with six biopsies in total: three from the ascending and three from the descending colon, even if no macroscopic endoscopic signs are visible. Such biopsies require extensive histopathological evaluation under a microscope to reach a definitive diagnosis and to initiate rational therapy, as medicines are available to control symptoms of microscopic colitis.

All patients diagnosed with microscopic colitis should be recommended to stop smoking and any culprit medication should be discontinued. Although the current treatment options for microscopic colitis are affiliated with limitations, the management of microscopic colitis aims to resolve symptoms and, in this way, improve the quality of life of these patients. Oral budesonide is the drug of choice, but nonsteroidal medications with reasonable response rates, such as bismuth subsalicylate, biologics, bile acid sequestrants, and the supportive antidiarrheal drug loperamide followed by thiopurines (for maintenance therapy only), may be indicated as alternatives for those who are dependent, intolerant, or even fail to respond to this medication [66]. Nevertheless, even if a standard treatment regimen with budesonide (9 mg daily for 6–8 weeks) is usually prescribed, it is still unclear as to how long patients with microscopic colitis on the alternative treatment options should be treated, or if any prophylactic therapy exists.

Finally, as microscopic colitis—a chronic disease with recurrent non-bloody, secretory diarrhea—can be a disabling life experience with impacts on every aspect of patients’ lives, including urgency and often unpredictable fecal incontinence, patients with symptoms should be offered regular follow-ups, and all elderly individuals with microscopic colitis should have easy access to a gastroenterologist in case of flaring disease. In this way, microscopic colitis deserves the same attention as the classical entities of inflammatory bowel diseases.