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Self-Reported Non-adherence to Medication in Japanese Patients with Cardiovascular Diseases

  • Original Research Article
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American Journal of Cardiovascular Drugs Aims and scope Submit manuscript

Abstract

Objective

Non-adherence to medication is an important problem in cardiovascular treatment. The aim of this study was to assess self-reported non-adherence in Japanese patients with cardiovascular disease.

Methods

A total of 1372 outpatients at three university hospitals who completed self-reported questionnaires were analyzed in this prospective study (mean age 67 ± 12 years; 31% female). Self-reported adherence to cardiovascular drugs was measured with a modified Siegal scale. Depressive symptoms were defined as a Patient Health Questionnaire-9 score of ≥ 10.

Results

A total of 227 patients (17%) were defined as non-adherent. Multiple logistic regression analysis showed that ≥ 2 times daily dosing frequency, age < 65 years and active employment were significantly associated with non-adherence, with odds ratios of 4.42 [95% confidence interval (CI) 3.02–6.48], 1.70 (95% CI 1.23–2.35) and 1.43 (95% CI 1.03–1.99), respectively. However, depression was not a significant factor in non-adherence.

Conclusions

Our study showed that self-reported non-adherence to medications was 17% in Japanese patients with cardiovascular disease in the university hospital setting. Daily dosing frequency, younger age and employment were significantly associated with non-adherence.

Trial Registration

University hospital Medical Information Network Clinical Trials Registry (UMIN-CTR) no. UMIN 000023514.

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Acknowledgements

We thank Professor Hiroshi Kasanuki, Dr. Hiroto Ito and the Japanese Society of Psychosomatic Cardiology for their support and the research coordinators at Asmo Clinical Pharmacology Laboratories, Ltd., for their assistance.

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Authors and Affiliations

  1. Department of Cardiology, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan

    Tsuyoshi Suzuki, Tsuyoshi Shiga & Nobuhisa Hagiwara

  2. Department of Medicine, Tokyo Women’s Medical University Medical Center East, Tokyo, Japan

    Hisako Omori

  3. Department of Cardiology, Institute of Geriatrics, Tokyo Women’s Medical University, Tokyo, Japan

    Fujio Tatsumi

  4. Department of Psychiatry, Tokyo Women’s Medical University, Tokyo, Japan

    Katsuji Nishimura

Authors
  1. Tsuyoshi Suzuki
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  2. Tsuyoshi Shiga
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  3. Hisako Omori
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  4. Fujio Tatsumi
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  5. Katsuji Nishimura
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  6. Nobuhisa Hagiwara
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Corresponding author

Correspondence to Tsuyoshi Shiga.

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Funding

This study was supported by the Health and Labour Sciences Research Grant (H24-Seishin-Ippan-001).

Conflict of interest

Dr. Shiga has received lecture fees from Toa Eiyo and Daiichi-Sankyo. Dr. Hagiwara has received research funding from Eisai, Nippon Boehringer Ingelheim and Daiichi-Sankyo and has received lecture fees from Nippon Boehringer Ingelheim and Bristol-Myers Squibb. The other authors, T. Suzuki, H. Omori, F. Tatsumi, and K. Nishimura, have nothing to disclose.

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Suzuki, T., Shiga, T., Omori, H. et al. Self-Reported Non-adherence to Medication in Japanese Patients with Cardiovascular Diseases. Am J Cardiovasc Drugs 18, 311–316 (2018). https://doi.org/10.1007/s40256-018-0278-z

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  • DOI: https://doi.org/10.1007/s40256-018-0278-z

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