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ICG and Sunitinib-loaded NH2-MOFs for Folate-mediated Hepatocellular Carcinoma Dual-modal Therapy

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Chemical Research in Chinese Universities Aims and scope

Abstract

This research investigated a novel folic acid(FA)-modified zirconium core metal-organic framework(MOF) Uio-66 as a nanocarrier to deliver indocyanine green(ICG) and Sunitinib to cancer cells for combination therapy. Platinum-loaded Uio-66 nanoparticles(Pu) were synthesized via a one-pot method, followed by the modification with FA on their surfaces. This afforded FPu that enabled subsequent loading of ICG and Sunitinib to achieve dual-modal cancer therapy. Drug loading/release test and singlet oxygen detection were also conducted in vitro, and the nanoparticles showed considerable drug loading efficiency for both ICG and Sunitinib, coupled with a high singlet oxygen generation rate. Specifically, drug loading and encapsulation efficiency of Sunitinib were 2.30% and 72.67%, while those for ICG were 2.87% and 90.28%, respectively. Additionally, cytotoxicity test on HepG2 human hepatocellular carcinoma cancer cell line revealed that the fully functional nanoparticles possess excellent biocompatibility and as such could be further investigated as a potential drug delivery system for effectual carcinoma cancer treatment.

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References

  1. Finn R. S., Zhu A.X., Hepatology, 2021, 73, 150

    Article  Google Scholar 

  2. https://www.iarc.who.int/faq/latest-global-cancer-data-2020-qa/ Accessed on 2021-04-26

  3. Lee H. A., Park S., Seo Y. S., Yoon W. S., Shin I. S., Rim C. H., J. Hepatobiliary Pancreat Sci., Epub Ahead of print, PMID: 33179421

  4. McGlynn K. A., Petrick J. L., El-Serag H. B., Hepatology, 2021, 73, 4

    Article  CAS  Google Scholar 

  5. Huang A., Yang X. R., Chung W. Y., Dennison A. R., Zhou J., Signal Transduct Target Ther., 2020, 5, 146

    Article  Google Scholar 

  6. Zhu A. X., Sahani D. V., Duda D. G., di Tomaso E., Ancukiewicz M., Catalano O. A., Sindhwani V., Blaszkowsky L. S., Yoon S. S., Lahdenranta J., Bhargava P., Meyerhardt J., Clark J. W., Kwak E. L., Hezel A. F., Miksad R., Abrams T. A., Enzinger P. C., Fuchs C. S., Ryan D. P., Jain R. K., J. Clin. Oncol., 2009, 27, 3027

    Article  CAS  Google Scholar 

  7. Polom K., Murawa D., Rho Y. S., Nowaczyk P., Hünerbein M., Murawa P., Cancer, 2011, 117(21), 4812

    Article  Google Scholar 

  8. Baj J., Sitarz R., Łokaj M., Forma A., Czeczelewski M., Maani A., Garruti G., Molecules, 2020, 25(7), 1724

    Article  CAS  Google Scholar 

  9. Zhang X., Li Y., Wei M., Liu C., Yu T., Yang J., Drug Deliv., 2019, 26(1), 129

    Article  CAS  Google Scholar 

  10. Wang Y., Xie Y., Li J., Peng Z. H., Sheinin Y., Zhou J., Oupický D., ACS Nano, 2017, 11(2), 2227

    Article  CAS  Google Scholar 

  11. Yu Z., Xiao Z., Shuai X., Tian J., J. Mater. Chem. B, 2020, 8(30), 6418

    Article  CAS  Google Scholar 

  12. Desmettre T., Devoisselle J. M., Mordon S., SurvOphthalmol, 2000, 45(1), 15

    CAS  Google Scholar 

  13. Santos J. H., Quimque M. T. J., Macabeo A. P. G., Corpuz M. J. T., Wang Y. M., Lu T. T., Lin C. H., Villaflores O. B., Pharmaceutics, 2020, 12(5), 437

    Article  CAS  Google Scholar 

  14. Jarai B. M., Stillman Z., Attia L., Decker G. E., Bloch E. D., Fromen C. A., ACS Appl Mater Interfaces, 2020, 12(35), 38989

    Article  CAS  Google Scholar 

  15. Liu C., Luo L., Zeng L., Xing J., Xia Y., Sun S., Zhang L., Yu Z., Yao J., Yu Z., Akakuru O. U., Saeed M., Wu A., Small, 2018, 14(35), e1801851

    Article  Google Scholar 

  16. Ogiwara N., Kobayashi H., Concepción P., Rey F., Kitagawa H., Angew. Chem. Int. Ed. Engl., 2019, 58(34), 11731

    Article  CAS  Google Scholar 

  17. Zhang W., Ji W., Li L., Qin P., Khalil I. E., Gu Z., Wang P., Li H., Fan Y., Ren Z., Shen Y., Zhang W., Fu Y., Huo F., ACS Appl. Mater. Interfaces, 2020, 12(47), 52660

    Article  CAS  Google Scholar 

  18. Chen S. S., Hu C., Liu C. H., Chen Y. H., Ahamad T., Alshehri S. M., Huang P. H., Wu K. C., J. Hazard Mater., 2020, 397, 122431

    Article  CAS  Google Scholar 

  19. Dong H., Yang G. X., Zhang X., Meng X. B., Sheng J. L., Sun X. J., Feng Y. J., Zhang F. M., Chemistry, 2018, 24(64), 17148

    Article  CAS  Google Scholar 

  20. Gao X., Cui R., Ji G., Liu Z., Nanoscale, 2018, 10(13), 6205

    Article  CAS  Google Scholar 

  21. Dong H., Yang G. X., Zhang X., Meng X. B., Sheng J. L., Sun X. J., Feng Y. J., Zhang F. M., Chemistry, 2018, 24(64), 17148

    Article  CAS  Google Scholar 

  22. Liu M. C., Liu L., Wang X. R., Shuai W. P., Hu Y., Han M., Gao J. Q., Int. J. Nanomedicine, 2016, 11, 1395

    Article  Google Scholar 

  23. Koirala N., Das D., Fayazzadeh E., Sen S., McClain A., Puskas J. E., Drazba J. A., McLennan G., J. Biomed. Mater. Res. A, 2019, 107(11), 2522

    Article  CAS  Google Scholar 

  24. Kulkarni T. A., Bade A. N., Sillman B., Shetty B. L. D., Wojtkiewicz M. S., Gautam N., Hilaire J. R., Sravanam S., Szlachetka A., Lamberty B. G., Morsey B. M., Fox H. S., Alnouti Y., McMillan J. M., Mosley R. L., Meza J., Domanico P. L., Yue T. Y., Moore G., Edagwa B. J., Gendelman H. E., Nat. Mater., 2020, 19(8), 910

    Article  CAS  Google Scholar 

  25. Unciti-Broceta J. D., Arias J. L., Maceira J., Soriano M., Ortiz-González M., Hernández-Quero J., Muñóz-Torres M., de Koning H. P., Magez S., Garcia-Salcedo J. A., PLoSPathog, 2015, 11(6), e1004942

    Google Scholar 

  26. Cassidy L. D., Young A. R., Pérez-Mancera P. A., Nimmervoll B., Jaulim A., Chen H. C., McIntyre D. J. O., Brais R., Ricketts T., Pacey S., De La Roche M., Gilbertson R. J., Rubinsztein D. C., Narita M., Autophagy, 2018, 14(7), 1256

    Article  Google Scholar 

  27. Singletary M., Lau J. W., Hagerty S., Pustovyy O., Globa L., Vodyanoy V., Sci. Rep., 2020, 10(1), 18435

    Article  CAS  Google Scholar 

  28. Rojas S., Colinet I., Cunha D., Hidalgo T., Salles F., Serre C., Guillou N., Horcajada P., ACS Omega., 2018, 3(3), 2994

    Article  CAS  Google Scholar 

  29. Tabatabaeian K., Simayee M., Fallah-Shojaie A., Mashayekhi F., Daru., 2019, 27(1), 307

    Article  CAS  Google Scholar 

  30. Farboudi A., Mahboobnia K., Chogan F., Karimi M., Askari A., Banihashem S., Davaran S., Int. J. Biol. Macromol., 2020, 150, 178

    Article  CAS  Google Scholar 

  31. van Dam G. M., Themelis G., Crane L. M., Harlaar N. J., Pleijhuis R. G., Kelder W., Sarantopoulos A., de Jong J. S., Arts H. J., van der Zee A. G., Bart J., Low P. S., Ntziachristos V., Nat. Med., 2011, 17(10), 1315

    Article  CAS  Google Scholar 

  32. Zhou Y., Unno K., Hyjek E., Liu H., Zimmerman T., Karmakar S., Putt K. S., Shen J., Low P. S., Wickrema A., Leuk Lymphoma, 2018, 59(12), 2982

    Article  CAS  Google Scholar 

  33. Kamen B. A., Smith A. K., Adv. Drug Deliv. Rev., 2004, 56(8), 1085

    Article  CAS  Google Scholar 

  34. Brown Jones M., Neuper C., Clayton A., Mariani A., Konecny G., Thomas M. B., Keeney G., Hartmann L., Podratz K. C., Int. J. Cancer., 2008, 123(7), 1699

    Article  Google Scholar 

  35. Iwakiri S., Sonobe M., Nagai S., Hirata T., Wada H., Miyahara R., Ann. Surg. Oncol., 2008, 15(3), 889

    Article  Google Scholar 

  36. Liu Y., Yang G., Jin S., Xu L., Zhao C. X., Chempluschem, 2020, 85(9), 2143

    Article  CAS  Google Scholar 

  37. Itatani Y., Kawada K., Yamamoto T., Sakai Y., Int. J. Mol. Sci., 2018, 19(4), 1232

    Article  Google Scholar 

  38. Yang Y., Li N., Chen T., Zhang C., Liu L., Qi Y., Bu P., Pharm. Biol., 2019, 57(1), 625

    Article  CAS  Google Scholar 

  39. Yang Y., Li N., Chen T., Zhang C., Li J., Liu L., Qi Y., Zheng X., Zhang C., Bu P., Arch. Toxicol., 2019, 93(11), 3249

    Article  CAS  Google Scholar 

  40. Zhao Q., Zhang T., Xiao X. R., Huang J. F., Wang Y., Gonzalez F. J., Li F., Br. J. Pharmacol., 2019, 176(13), 2162

    CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

This work was supported by the Ningbo Natural Science Foundation, China(No.202003N4253) and the Southeast University-China Pharmaceutical University Cooperative Research Project, China(No.2242019K3DZ06).

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Authors and Affiliations

  1. School of Medicine, Southeast University, Nanjing, 210009, P. R. China

    Zhoujing Zhang, Wenjing Xu & Yewei Zhang

  2. Cixi Institute of BioMedical Engineering, CNITECH, Chinese Academy of Sciences, Ningbo, 315201, P. R. China

    Zhoujing Zhang, Chuang Liu, Ozioma Akakuru & Aiguo Wu

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  1. Zhoujing Zhang
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  2. Chuang Liu
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  3. Ozioma Akakuru
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  4. Wenjing Xu
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  5. Aiguo Wu
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Correspondence to Aiguo Wu or Yewei Zhang.

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Zhang, Z., Liu, C., Akakuru, O. et al. ICG and Sunitinib-loaded NH2-MOFs for Folate-mediated Hepatocellular Carcinoma Dual-modal Therapy. Chem. Res. Chin. Univ. 37, 967–974 (2021). https://doi.org/10.1007/s40242-021-1206-3

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  • DOI: https://doi.org/10.1007/s40242-021-1206-3

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