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Anti-diabetic potential of Urtica Dioica: current knowledge and future direction

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Abstract

Aim

This review summarizes studies on the anti-diabetic effect of Urtica Dioica (UD) in Type-2-diabetes.

Materials and methods

We studied worldwide traditional medicines, old texts, and published literature for anti-diabetic effect of UD. Electronic databases comprising PubMed, Web of Science, Science Direct, Scopus and Google Scholar were searched to collect articles published between 1990 and 2021 years.

Results

Our literature investigation suggests UD as a glucose lowering, blood lipid regulating, anti-inflammatory and anti-oxidation plant.

Conclusions

UD’s anti-diabetic properties make it potential traditional therapeutics for lowering the clinical manifestations of T2DM through affecting hyperglycemia and therefore suggest it as a proper medication with no or limited side effects.

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Funding

This work was supported by Tabriz University of Medical Sciences [grant number: 64989, Code of Ethics: IR.TBZMED.1399.093].

Author information

Authors and Affiliations

  1. Student Research Committee, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran

    Anita Chehri

  2. Department of Persian Medicine, Faculty of Traditional Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

    Anita Chehri & Mostafa Araj-Khodaei

  3. Type 1 Diabetes Research, Department of Clinical Research, Translational , Steno Diabetes Center Copenhagen, Gentofte, Denmark

    Reza Yarani & Flemming Pociot

  4. Psychiatry Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran

    Zahra Yousefi

  5. Physical Medicine Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran

    Tannaz Novin Bahador & Seyed Kazem Shakouri

  6. Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

    Alireza Ostadrahimi

  7. Department of Internal Medicine, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

    Majid Mobasseri

  8. Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

    Flemming Pociot

  9. Research Center for Integrative Medicine in Aging, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran

    Mostafa Araj-Khodaei

Authors
  1. Anita Chehri
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  2. Reza Yarani
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  3. Zahra Yousefi
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  7. Majid Mobasseri
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  9. Mostafa Araj-Khodaei
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Contributions

Conceptualization: Mostafa Araj-Khodaei.

Data curation: Mostafa Araj-Khodaei, Reza Yarani.

Formal analysis: Flemming Pociot, Tannaz Novin Bahador.

Funding acquisition: Mostafa Araj-Khodaei.

Investigation: Tannaz Novin Bahador, Zahra Yousefi.

Methodology: Anita Chehri, Seyed Kazem Shakouri.

Project administration: Mostafa Araj-Khodaei, Reza Yarani.

Resources: Majid Mobasseri, Alireza Ostadrahimi.

Supervision: Mostafa Araj-Khodaei, Reza Yarani.

Validation: Anita Chehri.

Writing – original draft: Anita Chehri, Tannaz Novin Bahador.

Writing – review & editing: Mostafa Araj-Khodaei, Reza Yarani.

Corresponding authors

Correspondence to Reza Yarani or Mostafa Araj-Khodaei.

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Chehri, A., Yarani, R., Yousefi, Z. et al. Anti-diabetic potential of Urtica Dioica: current knowledge and future direction. J Diabetes Metab Disord 21, 931–940 (2022). https://doi.org/10.1007/s40200-021-00942-9

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