Abstract
Purpose of Review
To provide an updated evaluation of the literature regarding safety and outcomes in pediatric bariatric surgery and to explore associated controversies related to surgical timing and age concerns, as well as other ethical issues.
Recent Findings
Nonsurgical management of pediatric patients with obesity becomes less effective with increasing age and severity of disease. For carefully selected adolescent patients, bariatric surgery has been shown to provide sustained weight loss, reduction in comorbidities, and improved quality of life; however, high-level evidence is limited. Current data support surgical intervention in obese adolescents prior to adulthood, as several comorbidities and cardiovascular risk factors appear to be increasingly responsive to weight loss at a younger age. There is inadequate information available in pediatric patients to support one type of surgical intervention over another, or weight loss surgery in preadolescent patients.
Summary
Large trials have begun to more clearly delineate the risks and benefits of adolescent bariatric surgery. As the use of this important intervention increases, it is important that standards of care are agreed upon and that continuing study helps define appropriate patient selection and method of intervention.
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References
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Nishtar S, Gluckman P, Armstrong T. Ending childhood obesity: a time for action. Lancet. 2016;387(10021):825–7. doi:10.1016/S0140-6736(16)00140-9.
Sugerman H. Bariatric surgery for severely obese adolescents. J Gastrointest Surg. 2003;7(1):102–8. doi:10.1016/S1091-255X(02)00125-7.
August GP, Caprio S, Fennoy I, et al. Prevention and treatment of pediatric obesity: an endocrine society clinical practice guideline based on expert opinion. J Clin Endocrinol Metab. 2008;93(12):4576–99. doi:10.1210/jc.2007-2458.
Barlow SE. Expert committee. Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Pediatrics. 2007;120(Suppl 4):S164–92. doi:10.1542/peds.2007-2329C.
• Kelly AS, Barlow SE, Rao G, et al. Severe obesity in children and adolescents: identification, associated health risks, and treatment approaches: a scientific statement from the American Heart Association. Circulation. 2013; 128(15):1689–1712. doi: 10.1161/CIR.0b013e3182a5cfb3. A summary of the current status of pediatric obesity in the United States from the American Heart Association.
Danielsson P, Kowalski J, Ekblom Ö, Marcus C. Response of severely obese children and adolescents to behavioral treatment. Arch Pediatr Adolesc Med. 2012;166(12):1103–8. doi:10.1001/2013.jamapediatrics.319.
Kalarchian MA, Levine MD, Arslanian SA, et al. Family-based treatment of severe pediatric obesity: randomized, controlled trial. Pediatrics. 2009;124(4):1060–8. doi:10.1542/peds.2008-3727.
van der Baan-Slootweg O, Benninga MA, Beelen A, et al. Inpatient treatment of children and adolescents with severe obesity in the Netherlands: a randomized clinical trial. JAMA Pediatr. 2014;168(9):807–14. doi:10.1001/jamapediatrics.2014.521.
Berkowitz RI, Wadden TA, Gehrman CA, et al. Meal replacements in the treatment of adolescent obesity: a randomized controlled trial. Obesity. 2011;19(6):1193–9. doi:10.1038/oby.2010.288.
Sherafat-Kazemzadeh R, Yanovski SZ, Yanovski JA. Pharmacotherapy for childhood obesity: present and future prospects. Int J Obes. 2013;37(1):1–15. doi:10.1038/ijo.2012.144.
Kelly AS, Fox CK, Rudser KD, Gross AC, Ryder JR. Pediatric obesity pharmacotherapy: current state of the field, review of the literature and clinical trial considerations. Int J Obes. 2016;40(7):1043–50. doi:10.1038/ijo.2016.69.
Weiner JP, Goodwin SM, Chang H-Y, et al. Impact of bariatric surgery on health care costs of obese persons: a 6-year follow-up of surgical and comparison cohorts using health plan data. JAMA Surg. 2013;148(6):555–62. doi:10.1001/jamasurg.2013.1504.
Kelleher DC, Merrill CT, Cottrell LT, Nadler EP, Burd RS. Recent national trends in the use of adolescent inpatient bariatric surgery: 2000 through 2009. JAMA Pediatr. 2013;167(2):126–32. doi:10.1001/2013.jamapediatrics.286.
Nguyen NT, Nguyen B, Gebhart A, Hohmann S. Changes in the makeup of bariatric surgery: a national increase in use of laparoscopic sleeve gastrectomy. J Am Coll Surg. 2013;216(2):252–7. doi:10.1016/j.jamcollsurg.2012.10.003.
Zwintscher NP, Azarow KS, Horton JD, Newton CR, Martin MJ. The increasing incidence of adolescent bariatric surgery. J Pediatr Surg. 2013;48(12):2401–7. doi:10.1016/j.jpedsurg.2013.08.015.
Pallati P, Buettner S, Simorov A, Meyer A, Shaligram A, Oleynikov D. Trends in adolescent bariatric surgery evaluated by UHC database collection. Surg Endosc. 2012;26(11):3077–81. doi:10.1007/s00464-012-2318-0.
•• Inge TH, Zeller MH, Jenkins TM, et al. Perioperative outcomes of adolescents undergoing bariatric surgery: the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study. JAMA Pediatr. 2014; 168(1):47–53. doi: 10.1001/jamapediatrics.2013.4296. A prospective, multicenter study evaluating preoperative patient characteristics and short-term complications of adolescent bariatric surgery.
Slusser W, Staten K, Stephens K, et al. Payment for obesity services: examples and recommendations for stage 3 comprehensive multidisciplinary intervention programs for children and adolescents. Pediatrics. 2011;128(Suppl 2):S78–85. doi:10.1542/peds.2011-0480H.
Wulkan ML, Walsh SM. The multi-disciplinary approach to adolescent bariatric surgery. Semin Pediatr Surg. 2014;23(1):2–4. doi:10.1053/j.sempedsurg.2013.10.012.
Michalsky M, Reichard K, Inge T, Pratt J. ASMBS pediatric committee best practice guidelines. Surg Obes Relat dis. 2012;8(1):1–7.
Lau DCW, Douketis JD, Morrison KM, et al. 2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and children [summary]. CMAJ. 2007;176(8):S1–13. doi:10.1503/cmaj.061409.
International Pediatric Endosurgery Group (IPEG). IPEG guidelines for surgical treatment of extremely obese adolescents. J Laparoendosc Adv Surg Tech A. 2009; 19 (Suppl 1): xiv–xvi doi: 10.1089/lap.2009.9981.supp
Yermilov I, McGory ML, Shekelle PW, Ko CY, Maggard MA. Appropriateness criteria for bariatric surgery: beyond the NIH guidelines. Obesity (Silver Spring). 2009;17(8):1521–7. doi:10.1038/oby.2009.78.
Pratt JSA, Lenders CM, Dionne EA, et al. Best practice updates for pediatric/adolescent weight loss surgery. Obesity (Silver Spring). 2009;17(5):901–10. doi:10.1038/oby.2008.577.
Baur LA, Fitzgerald DA. Recommendations for bariatric surgery in adolescents in Australia and New Zealand. J Paediatr Child Health. 2010;46(12):704–7.
Jull A, Lawes CMM, Eyles H, et al. Clinical guidelines for weight management in New Zealand adults, children and young people. J Prim Health Care. 2011;3(1):66–71.
Fitch A, Fox C, Bauerly K, Heim C, et al. Prevention and management of obesity for children and adolescents. Institute for Clinical Systems Improvement; 2013. https://www.icsi.org/_asset/tn5cd5/ObesityChildhood.pdf.
Ingelfinger JR. Bariatric surgery in adolescents. N Engl J Med. 2011;365(15):1365–7. doi:10.1056/NEJMp1109981.
Heart TN. Executive Summary of the Clinical Guidelines on the identification, evaluation, and treatment of overweight and obesity in adults. J Am Diet Assoc. 1998;98(10):1178–91. doi:10.1016/S0002-8223(98)00276-4.
Inge TH, Krebs NF, Garcia VF, et al. Bariatric surgery for severely overweight adolescents: concerns and recommendations. Pediatrics. 2004;114(1):217–23.
Wulkan ML, Walsh SM. The multi-disciplinary approach to adolescent bariatric surgery. Semin Pediatr Surg. 2014;23(1):2–4. doi:10.1053/j.sempedsurg.2013.10.012.
Sysko R, Zandberg LJ, Devlin MJ, Annunziato RA, Zitsman JL, Walsh BT. Mental health evaluations for adolescents prior to bariatric surgery: a review of existing practices and a specific example of assessment procedures. Clin Obes. 2013;3(3–4):62–72. doi:10.1111/cob.12019.
Patel AG, Murgatroyd B, Ashton WD. Single incision laparoscopic adjustable gastric banding: 111 cases. Surg Obes Relat Dis. 2012;8(6):747–51. doi:10.1016/j.soard.2011.06.013.
Cummings DE, Weigle DS, Frayo RS, et al. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med. 2002;346(21):1623–30. doi:10.1056/NEJMoa012908.
Anderson B, Switzer NJ, Almamar A, Shi X, Birch DW, Karmali S. The impact of laparoscopic sleeve gastrectomy on plasma ghrelin levels: a systematic review. Obes Surg. 2013;23(9):1476–80. doi:10.1007/s11695-013-0999-7.
Pourcher G, De Filippo G, Ferretti S, Piquard C, Dagher I, Bougnères P. Short-term results of single-port sleeve gastrectomy in adolescents with severe obesity. Surg Obes Relat Dis. 2015;11(1):65–9. doi:10.1016/j.soard.2014.05.029.
Black JA, White B, Viner RM, Simmons RK. Bariatric surgery for obese children and adolescents: a systematic review and meta-analysis. Obes Rev. 2013;14(8):634–44. doi:10.1111/obr.12037.
Kelleher DC, Merrill CT, Cottrell LT, Nadler EP, Burd RS. Recent national trends in the use of adolescent inpatient bariatric surgery: 2000 through 2009. JAMA Pediatr. 2013;167(2):126–32. doi:10.1001/2013.jamapediatrics.286.
Varela JE, Hinojosa MW, Nguyen NT. Perioperative outcomes of bariatric surgery in adolescents compared with adults at academic medical centers. Surg Obes Relat Dis. 2007;3(5):537–40. doi:10.1016/j.soard.2007.07.002.
•• Inge TH, Courcoulas AP, Jenkins TM, et al. Weight loss and health status 3 years after bariatric surgery in adolescents. N Engl J Med. 2016; 374(2):113–123. doi:10.1056/NEJMoa1506699. A multicenter, prospective study evaluating outcomes for adolescent patients following bariatric surgery.
Inge TH, Zeller MH, Jenkins TM, et al. Perioperative outcomes of adolescents undergoing bariatric surgery: the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study. JAMA Pediatr. 2014;168(1):47–53. doi:10.1001/jamapediatrics.2013.4296.
Longitudinal Assessment of Bariatric Surgery (LABS) Consortium, Flum DR, Belle SH. Perioperative safety in the longitudinal assessment of bariatric surgery. N Engl J Med. 2009;361(5):445–54. doi:10.1056/NEJMoa0901836.
Helmiö M, Victorzon M, Ovaska J, et al. SLEEVEPASS: a randomized prospective multicenter study comparing laparoscopic sleeve gastrectomy and gastric bypass in the treatment of morbid obesity: preliminary results. Surg Endosc. 2012;26(9):2521–6. doi:10.1007/s00464-012-2225-4.
Miyano G, Jenkins TM, Xanthakos SA, Garcia VF, Inge TH. Perioperative outcome of laparoscopic Roux-en-Y gastric bypass: a children’s hospital experience. J Pediatr Surg. 2013;48(10):2092–8. doi:10.1016/j.jpedsurg.2013.05.019.
Olbers T, Gronowitz E, Werling M, et al. Two-year outcome of laparoscopic Roux-en-Y gastric bypass in adolescents with severe obesity: results from a Swedish nationwide study (AMOS). Int J Obes. 2012;36(11):1388–95. doi:10.1038/ijo.2012.160.
Paulus GF, de Vaan LEG, Verdam FJ, Bouvy ND, Ambergen TAW, van Heurn LWE. Bariatric surgery in morbidly obese adolescents: a systematic review and meta-analysis. Obes Surg. 2015;25(5):860–78. doi:10.1007/s11695-015-1581-2.
• Lennerz BS, Wabitsch M, Lippert H, et al. Bariatric surgery in adolescents and young adults–safety and effectiveness in a cohort of 345 patients. Int J Obes (Lond). 2014;38(3):334–340. doi:10.1038/ijo.2013.182. Evaluation of safety and efficacy of adolescent bariatric surgery by analyzing a prospective registry in Germany.
Trends and outcomes of adolescent bariatric surgery in california, 2005–2007. Pediatrics. 2011;127(2): peds.2010–0412d–peds. 2010–0412d. doi:10.1542/peds.2010-0412d.
Silberhumer GR, Miller K, Pump A, et al. Long-term results after laparoscopic adjustable gastric banding in adolescent patients: follow-up of the Austrian experience. Surg Endosc. 2011;25(9):2993–9. doi:10.1007/s00464-011-1658-5.
Zitsman JL, DiGiorgi MF, Fennoy I, Kopchinski JS, Sysko R, Devlin MJ. Adolescent laparoscopic adjustable gastric banding (LAGB): prospective results in 137 patients followed for 3 years. Surg Obes Relat Dis. 2015;11(1):101–9. doi:10.1016/j.soard.2014.06.001.
• Stroh C, Köckerling F, Volker L, et al. Results of more than 11,800 sleeve gastrectomies: data analysis of the German bariatric surgery registry. Ann Surg. 2016; 263(5):949–955. doi:10.1097/SLA.0000000000001559. Evaluates technical complications following sleeve gastrectomy and identifies predictive factors.
Oberbach A, Neuhaus J, Inge T, et al. Bariatric surgery in severely obese adolescents improves major comorbidities including hyperuricemia. Metab, Clin Exp. 2014;63(2):242–9. doi:10.1016/j.metabol.2013.11.012.
Inge TH, Miyano G, Bean J, et al. Reversal of type 2 diabetes mellitus and improvements in cardiovascular risk factors after surgical weight loss in adolescents. Pediatrics. 2009;123(1):214–22. doi:10.1542/peds.2008-0522.
Holterman A, Gurria J, Tanpure S, DiSomma N. Non alcoholic fatty liver disease and bariatric surgery in adolescents. Semin Pediatr Surg. 2014;23(1):49–57. doi:10.1053/j.sempedsurg.2013.10.016.
Corey KE, Stanley TL, Misdraji J, et al. Prevalence and outcome of non-alcoholic fatty liver disease in adolescents and young adults undergoing weight loss surgery. Pediatr Obes. 2014;9(5):e91–3. doi:10.1111/j.2047-6310.2014.219.x.
Park JY, Song D, Kim YJ. Clinical experience of weight loss surgery in morbidly obese Korean adolescents. Yonsei Med J. 2014;55(5):1366–72. doi:10.3349/ymj.2014.55.5.1366.
Messiah SE, Lopez-Mitnik G, Winegar D, et al. Changes in weight and co-morbidities among adolescents undergoing bariatric surgery: 1-year results from the bariatric outcomes longitudinal database. Surg Obes Relat Dis. 2013;9(4):503–13. doi:10.1016/j.soard.2012.03.007.
Göthberg G, Gronowitz E, Flodmark C-E, et al. Laparoscopic Roux-en-Y gastric bypass in adolescents with morbid obesity–surgical aspects and clinical outcome. Semin Pediatr Surg. 2014;23(1):11–6. doi:10.1053/j.sempedsurg.2013.10.015.
Raziel A, Sakran N, Szold A, et al. Mid-term follow-up after laparoscopic sleeve gastrectomy in obese adolescents. Isr Med Assoc J. 2014;16(1):37–41.
Nadler EP, Barefoot LC, Qureshi FG. Early results after laparoscopic sleeve gastrectomy in adolescents with morbid obesity. Surgery. 2012;152(2):212–7. doi:10.1016/j.surg.2012.05.010.
McGuire MM, Nadler EP, Qureshi FG. Laparoscopic vertical sleeve gastrectomy for adolescents with morbid obesity. Semin Pediatr Surg. 2014;23(1):21–3. doi:10.1053/j.sempedsurg.2013.10.021.
Boza C, Viscido G, Salinas J, Crovari F, Funke R, Perez G. Laparoscopic sleeve gastrectomy in obese adolescents: results in 51 patients. Surg Obes Relat Dis. 2012;8(2):133–7. doi:10.1016/j.soard.2011.11.021.
Al-Sabah SK, Almazeedi SM, Dashti SA, Al-Mulla AY, Ali DA, Jumaa TH. The efficacy of laparoscopic sleeve gastrectomy in treating adolescent obesity. Obes Surg. 2015;25(1):50–4. doi:10.1007/s11695-014-1340-9.
Alqahtani AR, Elahmedi MO, Qahtani Al A. Co-morbidity resolution in morbidly obese children and adolescents undergoing sleeve gastrectomy. Surg Obes Relat Dis. 2014;10(5):842–50. doi:10.1016/j.soard.2014.01.020.
Holterman A-X, Browne A, Dillard BE, et al. Short-term outcome in the first 10 morbidly obese adolescent patients in the FDA-approved trial for laparoscopic adjustable gastric banding. J Pediatr Gastroenterol Nutr. 2007;45(4):465–73. doi:10.1097/MPG.0b013e318063eef6.
Zeller MH, Modi AC, Noll JG, Long JD, Inge TH. Psychosocial functioning improves following adolescent bariatric surgery. Obesity (Silver Spring). 2009;17(5):985–90. doi:10.1038/oby.2008.644.
Herget S, Rudolph A, Hilbert A, Blüher S. Psychosocial status and mental health in adolescents before and after bariatric surgery: a systematic literature review. Obes Facts. 2014;7(4):233–45. doi:10.1159/000365793.
Vanguri P, Lanning D, Wickham EP, Anbazhagan A, Bean MK. Pediatric health care provider perceptions of weight loss surgery in adolescents. Clin Pediatr (Phila). 2013;53(1):60–5. doi:10.1177/0009922813500848.
Schauer PR, Bhatt DL, Kirwan JP, et al. Bariatric surgery versus intensive medical therapy for diabetes–3-year outcomes. N Engl J Med. 2014;370(21):2002–13. doi:10.1056/NEJMoa1401329.
Juonala M, Magnussen CG, Berenson GS, et al. Childhood adiposity, adult adiposity, and cardiovascular risk factors. N Engl J Med. 2011;365(20):1876–85. doi:10.1056/NEJMoa1010112.
Schauer P. Effect of laparoscopic Roux-En Y gastric bypass on type 2 diabetes mellitus. Ann Surg. 2003;238:467–85.
Alqahtani AR, Antonisamy B, Alamri H, Elahmedi M, Zimmerman VA. Laparoscopic sleeve gastrectomy in 108 obese children and adolescents aged 5–21 years. Ann Surg. 2012;256(2):266–73. doi:10.1097/SLA.0b013e318251e92b.
•Alqahtani A, Elahmedi M, Qahtani ARA. Laparoscopic sleeve gastrectomy in children younger than 14 years. Ann Surg. 2016; 263(2):312–319. doi:10.1097/SLA.0000000000001278. One of the first studies to evaluate bariatric surgery in pre-adolescent children.
Dan D, Harnanan D, Seetahal S, Naraynsingh V, Teelucksingh S. Bariatric surgery in the management of childhood obesity: should there be an age limit? Obes Surg. 2010;20(1):114–7. doi:10.1007/s11695-009-9996-2.
Mohaidly MA, Suliman A, Malawi H. Laparoscopic sleeve gastrectomy for a two-and half year old morbidly obese child. Int J Surg Case Rep. 2013;4(11):1057–60. doi:10.1016/j.ijscr.2013.07.033.
Willcox K, Warren N, O’Brien P. Patient and parent perspectives of adolescent Laparoscopic Adjustable Gastric Banding (LAGB). Obes Surg. 2016;. doi:10.1007/s11695-016-2156-6.
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Train, A.T., Dorman, R.M. & Harmon, C.M. Adolescent Bariatric Surgery: Quality, Outcomes, and Debates. Curr Surg Rep 5, 2 (2017). https://doi.org/10.1007/s40137-017-0165-6
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DOI: https://doi.org/10.1007/s40137-017-0165-6