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Presence and activities of carbonaceous nano-materials in Ayurvedic nano-medicine preparations

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Abstract

Ayurvedic nano-medicine preparations (ANMPs), Bhasma and Sindura, are considered as most effective dosage forms in Ayurveda. These are the preparations of metals and minerals used for therapeutic purposes in Ayurveda. Those are prepared by repeated trituration with liquid media from plant materials and incineration at high temperature above 650°C. These preparations are claimed as biologically produced nano-medicines formed by metallic/mineral nanoparticles. Presence of carbonaceous nano-materials is also reported in these preparations, in the form of fullerene and others. The complexes of metallic/mineral nanoparticles with carbonaceous nano-materials are formed by the processes of physisorption and chemisorption. The carbonaceous nano-materials are reported to have different biological effects. The ANMPs are safe and are having various biological activities, i.e., antioxidant, immunomodulatory, anti-inflammatory, antitumor, antibacterial, and others. These biological activities of ANMPs are due to the presence of nano-metal or mineral particles conjugated with carbonaceous nano-materials. The conjugation of metals and minerals nanoparticles with nano-carbons makes these preparations biologically safe and therapeutically more effective. Probable effects of the carbonaceous nano-materials present in the ANMPs are discussed in this review.

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References

  1. Sarkar, P.K., Chaudhuri, A.K.: Ayurvedic Bhasma: the most ancient application of nanomedicine. J. Sci. Ind. Res. 69(12), 901–905 (2010)

    CAS  Google Scholar 

  2. Bhargava, S.C., Reddy, K.R.C., Sastry, G.V.S.: Characterization of Lauha Bhasma. Int. J. Ayurvedic Med. 4(3), 194–202 (2013)

    Google Scholar 

  3. Singh, S.K., Chaudhary, A.K., Rai, D.K., Rai, S.B.: Preparation and characterization of a mercury based Indian traditional drug Ras-Sindoor. Indian J. Tradit. Knowl. 8(3), 346–351 (2009)

    Google Scholar 

  4. Aparna, C., Chowdari, P., Ghosh, S., Pawar, P., Patkar, M., Dakave, S., Gota, V., Chaudhari, P., Chiplunkar, S.V., Kane, S., Suresh, A.K., Bellare, J.: Bioactivity and safety studies of Jasad Bhasma and its in-process intermediate in Swiss Mice. J. Ethnopharmacol. 117, 73–86 (2017)

    Google Scholar 

  5. Pandit, S., Biswas, T.K., Debnath, P.K., Saha, A.V., Chowdhury, U., Shaw, B.P., Sen, S., Mukherjee, B.: Chemical and pharmacological evaluation of different Ayurvedic preparations of iron. J. Ethnopharmacol. 65, 149–156 (1999)

    Article  CAS  Google Scholar 

  6. Singh, R.K., Kumar, S., Aman, A.K., Karim, S.M., Kumar, S., Kar, M.: Study on physical properties of Ayurvedic nanocrystalline Tamra Bhasma by employing modern scientific tools. J. Ayurveda Integr. Med. 10, 88–93 (2019)

    Article  Google Scholar 

  7. Sarkar, P.K., Das, S., Prajapati, P.K.: Ancient concept of metal pharmacology based on Ayurvedic literature. Anc. Sci. Life 29(4), 1–6 (2010)

    Google Scholar 

  8. Sahu, A.K.: Nanotechnology in herbal medicines and cosmetics. Int. J. Res. Ayurveda Pharm. 4(3), 472–474 (2013)

    Article  Google Scholar 

  9. Winker, M.A., Flanagin, A., Chi-Lum, B., White, J., Andrews, K., Kennett, R.L., DeAngelis, C.D., Musacchio, R.A.: Guidelines for medical and health information sites on the internet: Principles governing AMA web sites. JAMA 283, 1600–1606 (2000)

    Article  CAS  Google Scholar 

  10. Wootton, J.: Directory of databases. The Vienna International Academy for Integrated medicine. The Rosenthal Center for Complementary and Alternative Medicine, Vienna (2004)

  11. Kumar, A., Nair, A.G.C., Reddy, A.V.R., Garg, A.N.: Unique Ayurvedic metallic-herbal preparations- chemical characterization. Biol. Trace Elem. Res. 109, 231–254 (2007)

    Article  Google Scholar 

  12. Beaudet, D., Badiles, S., Kuruvinashetti, K., Kashani, A.S., Jaunky, D., Ouellette, S., Piekny, A., Packirisamy, M.: Comparative study on cellular entry of incinerated ancient gold particles (Swarna Bhasma) and chemically synthesized gold particles. Sci. Rep. 7, 1–12 (2017)

    Article  CAS  Google Scholar 

  13. Netam, A.K., Bhargava, V.K., Singh, R., Sharma, P.: Physico-chemical characterization of Ayurvedic Swarna Bhasma by using SEM, EDX, XRD and PSA. J. Complemint. Med. Res. 12(2), 204–209 (2021). https://doi.org/10.5455/jcmr.2021.12.02.23

    Article  Google Scholar 

  14. Mukkavallia, S., Chalivendrab, V., Singh, B.R.: Physico-chemical analysis of herbally prepared silver nanoparticles and its potential as a drug bioenhancer. OpenNano 2, 19–27 (2017)

    Article  Google Scholar 

  15. Vrinda, Hiremath, S.G., Medikeri, S.S.: Characterization of Bhasmas of cast and wrought iron. Int. J. Ayurveda Pharm. Chem. 7(2), 359–370 (2017)

    CAS  Google Scholar 

  16. Singh, S.K., Rai, S.B.: Detection of carbonaceous materials in Naga Bhasma. Indian J. Pharm. Sci. 74(2), 178–183 (2012)

    Article  CAS  Google Scholar 

  17. Chaudhary, P., Lamba, N., Balian, S.K.: Analytical study of Vanga Bhasma. Int. J. Ayurvedic Med. 5(1), 82–90 (2014)

    Google Scholar 

  18. Kale, B., Rajurkar, N.: Synthesis and characterization of Vanga Bhasma. J. Ayurveda Integr. Med. 10, 111–118 (2019)

    Article  Google Scholar 

  19. Chandran, S., Patgiri, B.J., Bedarkar, P., Gokarna, R.A., Shukla, V.J.: Particle size estimation and elemental analysis of Yasada Bhasma. Int. J. Green Pharm. 11(4), 765–773 (2017)

    Google Scholar 

  20. Kantak, S., Rajurkar, N., Adhyapak, P.: Synthesis and characterization of Abhraka (mica) Bhasma by two different methods. J. Ayurveda Integr. Med. 11(3), 236–242 (2020). https://doi.org/10.1016/j.jaim.2018.11.003

    Article  Google Scholar 

  21. Wele, A., De, S., Dalvi, M., Devi, N., Pandit, V.: Nanoparticles of biotite mica as Krishna Vajra Abhraka Bhasma: synthesis and characterization. J. Ayurveda Integr. Med. 12, 269–282 (2021)

    Article  CAS  Google Scholar 

  22. Tripathi, A., Joshi, B., Singh, H.S., Rathore, J.S., Sharma, G.: Chemical phases of some of the Ayurvedic heamatinic medicines. Int. J. Eng. Sci. Technol. 8(2), 25–32 (2010)

    Google Scholar 

  23. Palbag, S., Mondal, S., Bardhan, T., Gautam, D.N.S.: Comparative physico-chemical validation between Arsenic-based Indian traditional drugs Haratal Bhasma and Rasamanikya. J. Ayurvedic Herb. Med. 2(2), 43–48 (2016)

    Article  Google Scholar 

  24. Mishra, A., Mishra, A.K., Tiwari, O.P., Jha, S.: In-house preparation and characterization of an Ayurvedic Bhasma: Pravala Bhasma. J. Integr. Med. 12(1), 52–58 (2014)

    Article  Google Scholar 

  25. Kumar, A., Nair, A.G.C., Reddy, A.V.R., Garg, A.N.: Availability of essential elements in Bhasmas: analysis of Ayurvedic metallic preparations by INAA. J. Radioanal. Nucl. Chem. 270, 173 (2006)

    Article  CAS  Google Scholar 

  26. Kadam, S.S., Jawale, R.W., Wadekar, M.: Chemical study of the diamond based Ayurvedic drug Hiraka Bhasma. Indian Science Congress, Chennai (2007)

    Google Scholar 

  27. Benn, T.M., Westerhoff, P., Herckes, P.: Detection of fullerenes (C60 and C70) in commercial cosmetics. Environ. Pollut. 159(5), 1334–1342 (2011)

    Article  CAS  Google Scholar 

  28. Paladhi, A., Rej, A., Sarkar, D., Singh, R., Bhattacharyya, S., Sarkar, P.K., Kar, P.K., Manna, P.P., Hira, S.K.: Nanoscale diamond-based formulation as an immunomodulator and potential therapeutic for Lymphoma. Front. Pharmacol. 13, 852065 (2022). https://doi.org/10.3389/fphar.2022.852065

    Article  CAS  Google Scholar 

  29. Ruidas, B., Sur, T.K., Pal, K., SomChaudhury, S., Prasad, P., Sinha, K., Sarkar, P.K., Das, P., DasMukhopadhyay, C.: Herbometallic nano-drug inducing metastatic growth inhibition in breast cancer through intracellular energy depletion. Mol. Biol. Rep. 47(5), 3745–3763 (2020). https://doi.org/10.1007/s11033-020-05467-7

    Article  CAS  Google Scholar 

  30. Kumar, N., Chamoli, P., Misra, M., Manoj, M.K., Sharma, A.: Advanced metal and carbon nanostructures for medical, drug delivery and bio-imaging applications. Nanoscale 14, 3987–4017 (2022)

    Article  CAS  Google Scholar 

  31. Wild, C., Koidl, P.: Thermal gas effusion from hydrogenated amorphous carbon films. Appl. Phys. Lett. 51, 1506–1508 (1987)

    Article  CAS  Google Scholar 

  32. Krusic, P.J., Wasserman, E., Keizer, P.N., Morton, J.R., Preston, K.F.: Radical reactions of C60. Science 254, 1183–1185 (1991)

    Article  CAS  Google Scholar 

  33. Liu, Y., Jiao, F., Qiu, Y., Li, W., Qu, Y., Tian, C., Li, Y., Bai, R., Lao, F., Zhao, Y., Chai, Z., Chen, C.: Immunostimulatory properties and enhanced TNF-alpha mediated cellular immunity for tumor therapy by C60(OH)20 nanoparticles. Nanotechnology 20(41), 415102 (2009)

    Article  Google Scholar 

  34. Petrovic, D., Seke, M., Srdjenovic, B., Djordjevic, A.: Applications of Anti/Prooxidant Fullerenes in Nanomedicine along with Fullerenes Influence on the Immune System. J. Nanomater. (2015). https://doi.org/10.1155/2015/565638

    Article  Google Scholar 

  35. Bakry, R., Vallant, R.M., Najam-ul-Haq, M., Rainer, M., Szabo, Z., Huck, C.W., Bonn, G.K.: Medicinal applications of fullerenes. Int. J. Nanomed. 2(4), 640–649 (2007)

    Google Scholar 

  36. Diez-Paskal, A.M.: State of the art in the antibacterial and antiviral applications of carbon-based polymeric nanocomposites. Int. J. Mol. Sci. 22, 10511 (2021). https://doi.org/10.3390/ijms221910511

    Article  CAS  Google Scholar 

  37. Prylutska, S.V., Burlaka, A.P., Klymenko, P.P., Grynyuk, I.I., Prylutskyy, Y.I., Schütze, C., Ritter, U.: Using water-soluble C60 fullerenes in anticancer therapy. Cancer Nanotechnol. 2(1–6), 105–110 (2011)

    Article  CAS  Google Scholar 

  38. Foley, S., Crowley, C., Smaihi, M., Bonfils, C., Erlanger, B.F., Seta, P., Larroque, C.: Cellular localisation of a water-soluble fullerene derivative. Biochem. Biophys. Res. Commun. 294, 116–119 (2002)

    Article  CAS  Google Scholar 

  39. Nielsen, G.D., Roursgaard, M., Jensen, K.A., Poulsen, S.S., Larsen, S.T.: In vivo biology and toxicology of fullerenes and their derivatives. Basic Clin. Pharmacol. Toxicol. 103, 197–208 (2008). https://doi.org/10.1111/j.1742-7843.2008.00266.x

    Article  CAS  Google Scholar 

  40. Dwivedi, A.D., Ma, L.Q.: Biocatalytic synthesis pathways, transformation, and toxicity of nanoparticles in the environment. Crit. Rev. Environ. Sci. Technol. 44, 1679–1739 (2014)

    Article  CAS  Google Scholar 

  41. Mahmood, M., Villagarcia, H., Dervishi, E., Mustafa, T., Alimohammadi, M., Casciano, D., Khodakovskaya, M., Biris, A.S.: Role of carbonaceous nanomaterials in stimulating osteogenesis in mammalian bone cells. J. Mater. Chem. B 1, 3220–3230 (2013)

    Article  CAS  Google Scholar 

  42. Shah, Z.A., Vohora, S.B.: Antioxidant/restorative effects of calcined gold preparations used in Indian systems of medicine against global and focal models of ischaemia. Pharmacol. Toxicol. 90(5), 254–259 (2002). https://doi.org/10.1034/j.1600-0773.2002.900505.x

    Article  CAS  Google Scholar 

  43. Mitra, A., Chakraborty, S., Auddy, B., Tripathi, P., Sen, S., Saha, A.V., Mukherjee, B.: Evaluation of chemical constituents and free-radical scavenging activity of Swarna Bhasma (gold ash), an Ayurvedic drug. J. Ethnopharmacol. 80(2–3), 147–153 (2002)

    Article  CAS  Google Scholar 

  44. Mukhi, P., Mohapatra, S.S., Bhattacharjee, M., Ray, K.K., Muraleedharan, T.S., Arun, A., Sathyavathi, R., Juluri, R.R., Satyam, P.V., Panda, A.K., Biswas, A., Nayak, S., Bojja, S., Pratihar, S., Roy, S.: Mercury based drug in ancient India: The red sulfide of mercury in nanoscale. J. Ayurveda Integr. Med. 8, 93–98 (2017)

    Article  Google Scholar 

  45. Pattanaik, N., Singh, A.V., Pandey, R.S., Singh, B.S., Kumar, M., Dixit, S.K., Tripathi, Y.B.: Toxicology and free radicals scavenging property of Tamra Bhasma. Indian J. Clin. Biochem. 18(2), 181–189 (2003). https://doi.org/10.1007/BF02867385

    Article  CAS  Google Scholar 

  46. Khedekar, S., Anupriya, Patgiri, B., Nariya, M., Prajapati, P.K.: Immunomodulatory activity of Swarna Prashana in Charle’s Foster albino rats. J. Ayurveda Med. Sci. 1(2), 90–96 (2016)

    Article  Google Scholar 

  47. Bafna, P.S., Patil, S.D.: Physicochemical characterisation and anti-inflammatory activity of Ayurvedic herbo-metallic Tamra Bhasma in acute and chronic models of inflammation. Mater. Technol. 33(10), 681–688 (2018)

    Article  CAS  Google Scholar 

  48. Chauhan, O., Godhwani, J.L., Khanna, N.K., Pendse, V.K.: Anti-inflammatory activity of Muktashukti Bhasma. Indian J. Exp. Biol. 36(10), 985–989 (1998)

    CAS  Google Scholar 

  49. Bajaj, S., Ahmad, I., Raisuddin, S., Vohora, S.B.: Augmentation of non-specific immunity in mice by gold preparations used in traditional systems of medicine. Indian J. Med. Res. 113, 192–196 (2001)

    CAS  Google Scholar 

  50. Bajaj, S., Vohora, S.B.: Analgesic activity of gold preparations used in Ayurveda & Unani-Tibb. Indian J. Med. Res. 108, 104–111 (1998)

    CAS  Google Scholar 

  51. Inder, D., Rehan, H.S., Bajaj, V.K., Kumar, P., Gupta, N., Singh, J.: Analgesic activity and safety of ash of silver used in Indian system of medicine in mice: A reverse pharmacological study. Indian J. Pharmacol. 44(1), 46–50 (2012)

    Article  CAS  Google Scholar 

  52. Tambekar, D.H., Dahikar, S.B.: Screening antibacterial activity of some Bhasma (metal-based herbal medicines) against enteric pathogens. Recent Res. Sci. Technol. 2(10), 59–62 (2010)

    Google Scholar 

  53. Dhundi, S.N., Prajapati, P.K.: Review on various experimental and clinical studies conducted on makaradhwaja. Ann. Ayurvedic Med. 2(3), 99–103 (2013)

    Google Scholar 

  54. Umrani, R.D., Agrawal, D.S., Paknikar, K.M.: Anti-diabetic activity and safety assessment of Ayurvedic medicine, Yasada Bhasma (zinc ash) in rats. Indian J. Exp. Biol. 51, 811–822 (2013)

    Google Scholar 

  55. Rajput, D.S., Patgiri, B.J., Galib, R., Prajapati, P.K.: Anti-diabetic formulations of Nāga Bhasma (lead calx): A brief review. Anc. Sci. Life 33(1), 52–59 (2013). https://doi.org/10.4103/0257-7941.134609

    Article  Google Scholar 

  56. Sharma, D.C., Budania, R., Shah, M., Jain, P., Gaur, B.L.: Hypolipidemic activity of silver preparations in chicks Gallus serregineus. Indian J. Exp. Biol. 42(5), 504–507 (2004)

    CAS  Google Scholar 

  57. Jagtap, C.Y., Ashok, B.K., Patgiri, B.J., Prajapati, P.K., Ravishankar, B.: Comparative anti-hyperlipidemic activity of Tamra Bhasma (incinerated copper) prepared from Shodhita (purified) and Ashodhita Tamra (raw copper). Indian J. Nat. Prod. Resour. 4(2), 205–211 (2013)

    Google Scholar 

  58. Mohapatra, S., Jha, C.B.: Evaluation of the effect of conventionally prepared Swarna Makshika Bhasma on different bio-chemical parameters in experimental animals. J. Ayurveda Integr. Med. 2(4), 187–191 (2011)

    Article  Google Scholar 

  59. Sarkar, P.K., Prajapati, P.K., Chaudhary, A.K., Shukla, V.J., Ravishankar, B.: Haematinic evaluation of Lauha Bhasma and Mandura Bhasma on HgCl2 induced anaemia in rats. Indian J. Pharm. Sci. 69(6), 791–795 (2007)

    Article  Google Scholar 

  60. Choudhary, A.K., Dixit, S.K.: The effect of Bhasmas of Makshika and Makshika Satva on the blood profile of rabbits. Anc. Sci. Life 17(2), 83–93 (1997)

    CAS  Google Scholar 

  61. Prajapati, P.K., Sarkar, P.K., Nayak, S.V., Joshi, R.D., Ravishankar, B.: Safety and toxicity profile of some metallic preparations of Ayurveda. Anc. Sci. Life 25(3), 57–66 (2006)

    CAS  Google Scholar 

  62. Dave, R.R., Sharma, H.S., Pillai, K.U.: A comparative study of Naga Bhasma with special reference to different media. AYU 13(8), 1–4 (1992)

    Google Scholar 

  63. Lin, C.M., Lu, T.Y.: C60 Fullerene derivatized nanoparticles and their application to therapeutics. Recent Pat. Nanotechnol. 6, 105–113 (2012)

    Article  CAS  Google Scholar 

  64. Kar, P., Banerjee, S., Chhetri, A., Sen, A.: Synthesis, physicochemical characterization and biological activity of synthesized Silver and Rajat Bhasma nanoparticles using Clerodendrum inerme. J. Phytol. 13, 64–71 (2021). https://doi.org/10.25081/jp.2021.v13.7026

    Article  CAS  Google Scholar 

  65. Singh, S.K., Gautam, D.N.S., Kumar, M., Rai, S.B.: Synthesis, characterization and histopathological study of a lead-based Indian traditional drug: Naga Bhasma. Indian J. Pharm. Sci. 72(1), 24–30 (2010)

    Article  CAS  Google Scholar 

  66. Scott, A., Duley, W.W., Pinho, G.P.: Polycyclic aromatic hydrocarbons and fullerenes as decomposition products of hydrogenated amorphous carbon. Astrophys. J. 489, L193–L195 (1997)

    Article  CAS  Google Scholar 

  67. Huang, T., Jin, B., Peng, R.F., Chen, C.D., Zheng, R.Z., He, Y., Chu, S.J.: Synthesis and characterization of fullerene-glycidyl azide polymer and its thermal decomposition. Polymers 7, 896–908 (2015). https://doi.org/10.3390/polym7050896

    Article  CAS  Google Scholar 

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Sarkar, P.K., Wele, A. Presence and activities of carbonaceous nano-materials in Ayurvedic nano-medicine preparations. Int Nano Lett 13, 41–51 (2023). https://doi.org/10.1007/s40089-022-00383-z

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