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Erythrocytic Oxidative Stress Indices and Haemato-biochemical Changes in Fluorotic Cattle from Industrial Fluorotic Zone of Odisha

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Proceedings of the National Academy of Sciences, India Section B: Biological Sciences Aims and scope Submit manuscript

Abstract

Effect of chronic fluorosis on haemato-biochemical parameters and oxidant-antioxidant equilibrium in cattle of industrial fluorotic zones of district Angul, Odisha, India was studied. Ten fluorotic cattle of visible clinical signs of endemic area and ten healthy cattle of non-fluorotic area were selected for the present study. Plasma fluoride level along with haemato-biochemical parameters was studied. Erythrocytic oxidative stress parameters like catalase, superoxide dismutase and lipid peroxidase were examined from 10 % red blood cell hemolysate. Statistical analysis of these two groups revealed altered haemato-biochemical parameters. There is high plasma fluoride level in the fluorotic cattle as compared to the healthy ones. The blood samples of the fluorotic cattle showed significant decrease (P ≤ 0.05) in haemoglobin, total erythrocyte count, total leucocyte count and packed cell volume as compared to healthy cattle. Differential leukocyte picture showed significant decrease (P ≤ 0.05) in neutrophil count in fluorotic cattle while increase in eosinophil, monocyte and lymphocyte percentage as compared to cattle of non fluorotic zone. Fluoride affected cattle revealed significantly higher (P ≤ 0.05) levels of alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen and creatinine level, whereas significant decrease (P ≤ 0.05) in plasma calcium level and increase in plasma phosphorous level was recorded in fluorotic cattle as compared to healthy ones. Marked increase (P ≤ 0.05) in lipid peroxidation whereas decrease in catalase and superoxide dismutase activities was observed in fluorotic cattle as compared to healthy ones.

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Acknowledgments

Dr. S. K. Panda, Professor, Department of Pathology, College of Veterinary Sciences is thankfully acknowledged for providing facilities for conducting haematological parameters of cattle. Financial support provided by University Grant Commission in terms of Major Research Project to the Dr. R. C. Patra, Principal Investigator is thankfully acknowledged.

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Authors and Affiliations

  1. Department of Clinical Veterinary Medicine, Ethics and Jurisprudence, College of Veterinary Science and Animal Husbandry, Orissa University of Agriculture and Technology, Bhubaneswar, Odisha, 751003, India

    Pinaki Samal

  2. College of Veterinary Science and Animal Husbandry, Orissa University of Agriculture and Technology, Bhubaneswar, 751003, India

    Ramesh Chandra Patra

  3. Department of Medicine, College of Veterinary Science and Animal Husbandry, Orissa University of Agriculture and Technology, Bhubaneswar, 751003, India

    Amit Raj Gupta

  4. Department of Animal Nutrition, College of Veterinary Science and Animal Husbandry, Orissa University of Agriculture and Technology, Bhubaneswar, 751003, India

    Kamdev Sethy

  5. Department of Veterinary Pharmacology, College of Veterinary Science and Animal Husbandry, Orissa University of Agriculture and Technology, Bhubaneswar, 751003, India

    Kautak Kumar Sardar

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  1. Pinaki Samal
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Correspondence to Pinaki Samal.

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Samal, P., Patra, R.C., Gupta, A.R. et al. Erythrocytic Oxidative Stress Indices and Haemato-biochemical Changes in Fluorotic Cattle from Industrial Fluorotic Zone of Odisha. Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci. 88, 573–578 (2018). https://doi.org/10.1007/s40011-016-0789-9

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  • DOI: https://doi.org/10.1007/s40011-016-0789-9

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