Skip to main content
SpringerLink
Log in

Isolation of Bioactive Marker Component, Butyryl Alkannin from Arnebia euchroma Roots and Its Efficacy Against Multidrug-Resistant Pathogens

  • Short Communication
  • Published:
National Academy Science Letters Aims and scope Submit manuscript

Abstract

This study was carried out to investigate the biomedicinal efficacy of a bioactive marker component, butyryl alkannin isolated from n-hexane root extract of Arnebia euchroma against vancomycin-intermediate Staphylococcus aureus (VISA) and methicillin-resistant S. aureus (MRSA) pathogens. As a result, butyryl alkannin showed significant antibacterial activity against multidrug-resistant pathogens of VISA and MRSA as minimum inhibitory concentration values which were found to be 1.56 and 1.56 μg/ml, respectively. These findings justify the biomedicinal efficacy of butyryl alkannin compound.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Salau AO, Odeleye OM (2007) Antimicrobial activity of Mucuna pruriens on selected bacteria. Afr J Biotechnol 6:2091–2092

    Google Scholar 

  2. Gutmann L, Billot-Klein D, Williamson R, Goldstein FW, Mounier J, Acar JF, Collatz E (1988) Mutation of Salmonella paratyphi: a conferring cross-resistance to several groups of antibiotics by decreased permeability and loss of invasiveness. Antimicrob Agent Chemother 32:195–201

    Article  Google Scholar 

  3. Cohen ML (1992) Epidemiology of drug resistance: implications for a postantimicrobialera. Science 257:1050–1055

    Article  Google Scholar 

  4. Samy RP, Ignacimuthu S (2000) Antibacterial activity of some folklore medicinal plants used by tribals in Western Ghats of India. J Ethnopharmacol 69:63–71

    Article  Google Scholar 

  5. Evans CE, Banso A, Samuel OA (2002) Efficacy of some nupe medicinal plants against Salmonella typhi: an in vitro study. J Ethnopharmacol 80:21–24

    Article  Google Scholar 

  6. Wang WJ, Bai JY, Lui DP, Xue LM, Zhu XY (1994) The anti-inflammatory activity of shikonin and its inhibitory effect on leukotriene B4 biosynthesis. Yaoxe Xuebao 29:161–165

    Google Scholar 

  7. You Y, Kim Y, Song GY, Ahn BZ (2000) (E)-6-(1-alkyloxyiminoalkyl)-5,8-dimethoxy-1,4-naphthoquinones: synthesis, cytotoxic activity and antitumor activity. Bioorg Med Chem Lett 10:2301–2303

    Article  Google Scholar 

  8. Kashiwada Y, Nishizawa M, Yamagishi T, Tanaka T, Nonaka G, Cosentino LM, Snider JV, Lee K (1995) Anti-AIDS agents, 18. Sodium and potassium salts of caffeic acid tetramers from Arnebia euchroma as anti-HIV agents. J Nat Prod 58:392–400

    Article  Google Scholar 

  9. Assimopoulou AN, Boskou D, Papageorgiou VP (2004) Antioxidant activities of alkannin, shikonin and Alkanna tinctoria root extracts in oil substrates. Food Chem 87:433–438

    Article  Google Scholar 

  10. Chen X, Yang L, Oppenheim JJ, Howard OMZ (2002) Cellular pharmacology studies of shikonin derivatives. Phytother Res 16:199–209

    Article  Google Scholar 

  11. Bajpai VK, Kang SC (2010) Antibacterial abietane-type diterpenoid, taxodone from Metasequoia glyptostroboides Miki ex Hu. J Biosci 35:533–538

    Article  Google Scholar 

  12. Bisht R, Katiyar A, Singh R, Mittal P (2009) Antibiotic resistance—a global issue of concern. Asian J PharmaClin Res 2:34–39

    Google Scholar 

  13. O’Donnell F, Smyth TJP, Ramachandran VN, Smyth WF (2010) A study of the antimicrobial activity of selected synthetic and naturally occurring quinolines. Int J Antimicrob Agent 35:30–38

    Article  Google Scholar 

  14. Subramani R, Kumar R, Prasad P, Aalbersberg W (2013) Cytotoxic and antibacterial substances against multi-drug resistant pathogens from marine sponge symbiont: citrinin, a secondary metabolite of Penicillium sp. Asian Pac J Trop Biomed 3:291–296

    Article  Google Scholar 

  15. Daszak P, Cunningham AA, Hyatt AD (2000) Emerging infectious diseases of wildlife: threats to biodiversity and human health. Science 287:443–449

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Botany and Microbiology, Gurukul Kangri University, Haridwar, 249-404, Uttrakhand, India

    Lokesh Kumar Singh & Dinesh Kumar Maheshwari

  2. Department of Applied Microbiology and Biotechnology, School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, 712-749, Republic of Korea

    Vivek K. Bajpai

Authors
  1. Lokesh Kumar Singh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dinesh Kumar Maheshwari
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Vivek K. Bajpai
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Dinesh Kumar Maheshwari or Vivek K. Bajpai.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Singh, L.K., Maheshwari, D.K. & Bajpai, V.K. Isolation of Bioactive Marker Component, Butyryl Alkannin from Arnebia euchroma Roots and Its Efficacy Against Multidrug-Resistant Pathogens. Natl. Acad. Sci. Lett. 38, 87–90 (2015). https://doi.org/10.1007/s40009-014-0290-z

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40009-014-0290-z

Keywords

Search

Navigation