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Trends, clinical characteristics, antimicrobial susceptibility patterns, and outcomes of Campylobacter bacteraemia: a multicentre retrospective study

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Abstract

Purpose

We aimed to explore the clinical characteristics of Campylobacter bacteraemia and identify the trends, risk factors for mortality, and antimicrobial susceptibility patterns from clinical samples.

Methods

This retrospective cohort study included patients confirmed to have Campylobacter bacteraemia from seven hospitals between January 2010 and June 2021. Data on demographics and underlying history, clinical manifestation, and antimicrobial susceptibility patterns were collected and analyzed. Annual cases of Campylobacter enteritis were extracted from a public database.

Results

A total of 108 patients were included, and five species were isolated. Campylobacter jejuni accounted for 54 (50.0%) cases and 17 (16%) patients had no symptoms other than fever. In-hospital mortality occurred in 14 (13.0%) patients. C. jejuni bacteraemia was associated with lower mortality compared to non-C. jejuni bacteraemia. Underlying cancer and septic shock were the significant factors associated with in-hospital mortality. Quinolone resistance was high (59%), whereas only 4% of isolates exhibited macrolide resistance. There has been a significant increase in the number of Campylobacter enteritis cases, which was strongly correlated with the number of Campylobacter bacteraemia cases (Pearson’s coefficient: 0.953; p < 0.0001).

Conclusion

The notably increasing incidence of Campylobacter bacteraemia and antibiotic resistance patterns can challenge the treatment, necessitating collective efforts of national surveillance and networks by many departments.

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Data availability

The data analysed during the current study is available from the corresponding author on reasonable request.

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Acknowledgements

We are grateful to the health and agriculture sector workers and health authorities striving to improve public health.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Author information

Authors and Affiliations

  1. Division of Infectious Diseases, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

    Yae Jee Baek, Eun Hwa Lee, Jin Young Ahn, Su Jin Jeong, Nam Su Ku, Jun Yong Choi, Joon-Sup Yeom, Young Goo Song & Jung Ho Kim

  2. Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Republic of Korea

    Yae Jee Baek

  3. Department of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang, Republic of Korea

    Je Eun Song

  4. Department of Infectious Diseases, Ajou University College of Medicine, Suwon, Republic of Korea

    Eun Jin Kim

  5. National Health Insurance Service Ilsan Hospital, Goyang, Republic of Korea

    Heun Choi

  6. Department of Internal Medicine, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea

    Yujin Sohn

  7. Department of Internal Medicine, Kangwon National University College of Medicine, Chuncheon, Republic of Korea

    Yong Duk Jeon

Authors
  1. Yae Jee Baek
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Contributions

YJB conceptualized the research question, collected data, conducted the analysis, and drafted the initial manuscript. JES, EJK, HC, YS, YDJ, and EHL collected data and carried out the data analysis. JYA, SJJ, NSK, JYC, J-SY, and YGS provided feedback on the research design and analysis. JHK contributed to conceiving the ideas, supervising the study, and reviewing the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Jung Ho Kim.

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Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical approval

The study protocol was approved by the Ethics Review Committee of Severance Hospital (approval no. 4-2021-1796). The requirement for informed consent was waived owing to the retrospective nature of the study.

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Baek, Y.J., Song, J.E., Kim, E.J. et al. Trends, clinical characteristics, antimicrobial susceptibility patterns, and outcomes of Campylobacter bacteraemia: a multicentre retrospective study. Infection (2023). https://doi.org/10.1007/s15010-023-02118-4

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