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Fecal carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae in Korean community and hospital settings

  • Clinical and Epidemiological Study
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Abstract

Purpose

The assessment and early recognition of risk factors for infections due to extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) are important for infection control and proper treatment. The aim of the present study was to investigate the prevalence of fecal carriage of ESBL-E in healthy individuals and hospitalized high-risk patients in Korea and to compare the characteristics of ESBL-E in these two groups.

Methods

A total of 384 samples from 290 healthy individuals and 94 high-risk patients were collected. The screening of ESBL-E was performed using a commercial chromogenic medium. Bacterial identification and antibiotic susceptibility testing were performed using the Vitek 2 system.

Results

The prevalence of ESBL-E carriage was 20.3 % in healthy individuals and 42.5 % in high-risk patients. Escherichia coli comprised a large majority (96.6 %) of the isolates from healthy individuals, but Klebsiella pneumoniae was more commonly detected (45.0 %) in high-risk patients than in healthy individuals. K. pneumoniae isolates exhibited significantly higher resistance to ceftazidime, ampicillin, and carbapenem, and E. coli exhibited higher resistance to cefotaxime. E. coli from high-risk patients exhibited significantly higher resistance to levofloxacin and cefepime than that from healthy individuals.

Conclusions

We demonstrated the high prevalence of ESBL-E carriage in Korea and clarified the characteristics of ESBL-E carriage in healthy individuals and high-risk patients. The distribution and antibiotic susceptibility of colonizing ESBL-E were different between the group of healthy individuals and the high-risk patients. Active surveillance of ESBL-E carriage is suggested for infection control, and the use of chromogenic agar appears to be an efficient method.

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Acknowledgments

This study was supported by Konkuk University in 2012.

Conflict of interest

None.

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Authors and Affiliations

  1. Department of Laboratory Medicine, Konkuk University School of Medicine, Konkuk University Hospital, 4-12, Hwayang-dong, Gwangjin-gu, Seoul, 143-729, Korea

    Y. J. Ko, H.-W. Moon, M. Hur, C.-M. Park & Y.-M. Yun

  2. Ewon Reference Laboratory, Seoul, Korea

    S. E. Cho

Authors
  1. Y. J. Ko
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  2. H.-W. Moon
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  3. M. Hur
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  4. C.-M. Park
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  5. S. E. Cho
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  6. Y.-M. Yun
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Corresponding author

Correspondence to H.-W. Moon.

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Ko, Y.J., Moon, HW., Hur, M. et al. Fecal carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae in Korean community and hospital settings. Infection 41, 9–13 (2013). https://doi.org/10.1007/s15010-012-0272-3

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  • DOI: https://doi.org/10.1007/s15010-012-0272-3

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