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Vaginal bleeding as primary presentation of renal cell carcinoma

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Abstract

Vaginal metastases from renal cell carcinoma has been recorded as extremely rare. We present a patient with vaginal bleeding as primary manifestation of renal cell carcinoma. A 40-year-old woman presented to a local private clinic with intermittent vaginal bleeding for approximately one month. Gynecological examination revealed a mass on the vaginal wall at approximately 8 o’clock. She underwent dilation and curettage (D&C) and mass excision. Microscopic histopathology and immunohistochemical stains showed vaginal metastases of clear cell RCC. The patient was referred to our urology clinic. Magnetic Resonance Imaging (MRI) of abdomen and pelvic showed a well-defined solid mass lesion measuring 16 × 12 × 11 cm in left kidney. Patient underwent left side radical nephrectomy through a left subcostal intraperitoneal incision. Histopathological results and metastasis workup confirmed the diagnosis of RCC with solitary metastatic vaginal lesion. After radical nephrectomy, she was treated with Sunitinib. No local relapse or distant metastasis was recognized 5 months after radical nephrectomy. In conclusion, the incidence of RCC metastasis to the vagina is extremely rare; but, in cases of vaginal bleeding or lesions we have to keep in mind the possibility of metastatic RCC.

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Authors and Affiliations

  1. Department of Urology, Firoozgar Hospital, Iran University of Medical Sciences, Valadi St., Valiasr Ave., 1593748711, Tehran, Iran

    Asaad Moradi, Behnam Shakiba, Robab Maghsoudi & Reza Dehghaniathar

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  1. Asaad Moradi
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  2. Behnam Shakiba
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  3. Robab Maghsoudi
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  4. Reza Dehghaniathar
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Correspondence to Behnam Shakiba.

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Authors have no conflict of interest.

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All procedures performed in present study were in accordance with the ethical standards of the ethical committee of Iran University of medical sciences and with the 1964 Helsinki Declaration.

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Informed consent was obtained from patient included in present study.

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Moradi, A., Shakiba, B., Maghsoudi, R. et al. Vaginal bleeding as primary presentation of renal cell carcinoma. CEN Case Rep 9, 138–140 (2020). https://doi.org/10.1007/s13730-019-00442-z

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  • DOI: https://doi.org/10.1007/s13730-019-00442-z

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