Skip to main content

Advertisement

SpringerLink
Log in

Evaluation of drug release property and blood compatibility of aspirin-loaded electrospun PLA/RSF composite nanofibers

  • Original Paper
  • Published:
Iranian Polymer Journal Aims and scope Submit manuscript

Abstract

In this paper, PLA/RSF with different mass ratios and aspirin-loaded PLA/RSF composite nanofiber membranes were prepared via electrospinning. Polylactic acid (PLA) and regenerated silk fibroin (RSF) were dissolved in trifluoroacetic acid and dichloromethane at a volume ratio of 70/30. The structure analysis made by Fourier transform infrared spectroscopy (FTIR) suggested that PLA and RSF blended very well in the composite membranes. In addition, scanning electron microscopy (SEM) and transmission electron microscopy (TEM) revealed that the average diameters of composite nanofibers were between 80 and 210 nm. Furthermore, the composite nanofibers had better uniformity in the range of the experiment, and the average diameter of composite nanofibers decreased with the increase of aspirin content. Wettability performance was investigated via contact water angle meter; the hydrophilic property of composite membranes had been improved with the existence of SF. Drug release property was tested by detecting the absorbency of drug in PBS solution via UV–visible spectroscopy, and the results showed that drug release rate reached the maximum when the mass ratio of PLA/RSF was 8/3. With the raise of aspirin content, the drug release rate increased. The in vitro anticoagulation behavior was studied by static platelet adhesion test. The results revealed that the anticoagulation property of composite membranes was superior to that of pure PLA nanofiber membranes. The anticoagulation property significantly improved in the presence of aspirin.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

References

  1. Fei YN, Chen Y, Wang HB, Gao WD, Yang RH, Wan YQ (2011) Preparation, characterization of antibacterial PLA/TP nanofibers. Fiber Polym 12:340–344

    Article  CAS  Google Scholar 

  2. Kim EN, Kim SH, Lee CH (2010) Electrospinning of polylactide fibers containing silver nanoparticles. Macromol Res 18:215–221

    Article  CAS  Google Scholar 

  3. Nagarwal RC, Kumar R, Dhanawat M, Pandit JK (2011) Modified PLA nano in situ gel: A potential ophthalmic drug delivery system. Colloids Surf B 86:28–34

    Article  CAS  Google Scholar 

  4. Dev A, Binulal NS, Anitha A, Nair SV, Furuike T, Tamura H, Jayakumar R (2010) Preparation of poly(lactic acid)/chitosan nanoparticles for anti-HIV drug delivery applications. Carbohydr Polym 80:833–838

    Article  CAS  Google Scholar 

  5. Rujiravanit R, Kruaykitanon S, Jamieson AM, Tokura S (2003) Preparation of crosslinked chitosan/silk fibroin blend films for drug delivery system. Macromol Biosci 3:604–611

    Article  CAS  Google Scholar 

  6. Tsukada M, Goto Y, Freddi G, Shiozaki H (1992) Chemical modification of silk with aromatic acid anhydrides. J Appl Polym Sci 45:1189–1194

    Article  CAS  Google Scholar 

  7. Wang XQ, Yucel T, Lu Q, Hu X, Kaplan DL (2010) Silk nanospheres and microspheres from silk/pva blend films for drug delivery. Biomaterials 31:1025–1035

    Article  CAS  Google Scholar 

  8. Wenk E, Wandrey AJ, Merkle HP, Meinel L (2008) Silk fibroin spheres as a platform for controlled drug delivery. J Control Release 132:26–34

    Article  CAS  Google Scholar 

  9. Meinel L, Betz O, Fajardo R, Hofmann S, Nazarian A, Cory E, Hilbe M, McCool J, Langer R, Vunjak-Novakovic G, Merkle HP, Rechenberg B, Kaplan DL, Kirer-Head C (2006) Silk based biomaterials to heal critical sized femur defects. Bone 39:922–931

    Article  CAS  Google Scholar 

  10. Hofmann S, Knecht S, Langer R, Kaplan DL, Vunjak-Novakovic G, Merkle HP, Meinel L (2006) Cartilage-like tissue engineering using silk scaffolds and mesenchymal stem cells. Tissue Eng 12:2729–2738

    Article  CAS  Google Scholar 

  11. Li LH, Li HB, Qian YN, Li X, Singh GK, Zhong L, Liu WQ, Lv YG, Cai KY, Yang L (2011) Electrospun poly (ε-caprolactone)/silk fibroin core-sheath nanofibers and their potential applications in tissue engineering and drug release. Int J Biol Macromol 49:223–232

    Article  CAS  Google Scholar 

  12. Galloway CF, Stevenson JC (2011) Aspirin in the primary prevention of cardiovascular disease. Maturitas 68:3–4

    Article  Google Scholar 

  13. Wang SD, Zhang YZ, Yin GB, Wang HW, Dong ZH (2009) Electrospun polylactide/silk fibroin–gelatin composite tubular scaffolds for small-diameter tissue engineering blood vessels. J Appl Polym Sci 113:2675–2682

    Article  CAS  Google Scholar 

  14. Zhang KH, Yin AL, Huang C, Wang CY, Mo XM, Al-Deyab SS, El-Newehy M (2011) Degradation of electrospun SF/P(LLA-CL) blended nanofibrous scaffolds in vitro. Polym Degrad Stab 96:2266–2275

    Article  CAS  Google Scholar 

  15. Zhou WT, He JX, Du S, Cui SZ, Gao WD (2011) Electrospun silk fibroin/cellulose acetate blend nanofibres: structure and properties. Iran Polym J 20:389–397

    CAS  Google Scholar 

  16. Chen Y, Lin J, Fei YN, Wang HB, Gao WD (2010) Preparation and characterization of electrospinning PLA/curcumin composite membranes. Fiber Polym 11:1128–1131

    Article  CAS  Google Scholar 

  17. He CL, Wang M, Cai XM, Huang XB, Li L, Zhu HM, Shen J, Yuan J (2011) Chemically induced graft copolymerization of 2-hydroxyethyl methacrylate onto polyurethane surface for improving blood compatibility. Appl Surf Sci 258:755–760

    Article  CAS  Google Scholar 

  18. Cheung H-Y, Lau K-T, Tao X-M, Hui D (2008) A potential material for tissue engineering: silkworm silk/PLA biocomposite. Compos Part B Eng 39:1026–1033

    Article  Google Scholar 

  19. Zhao YY, Yang QB, Lu XF, Wang C, Wei Y (2005) Study on correlation of morphology of electrospun products of polyacrylamide with ultrahigh molecular weight. J Polym Sci, Part B: Polym Phys 43:2190–2195

    Article  CAS  Google Scholar 

  20. Chen X, Knight DP, Shao ZZ, Vollrath F (2001) Regenerated bombyx silk solutions studied with rheometry and FTIR. Polym 42:09969–09974

    Article  CAS  Google Scholar 

  21. Risbud MV, Bhat SV, Bhonde RR, Hardika AA (2000) pH-sensitive freeze-dried chitosan–polyvinyl pyrrolidone hydrogels as controlled release system for antibiotic delivery. J Control Release 68:23–30

    Article  CAS  Google Scholar 

  22. Peng T, Yao KD, Yuan C, Goosen MFA (1994) Structural changes of pH-sensitive chitosan/polyether hydrogels in different pH solution. J Polym Sci A Polym Chem 32:591–596

    Article  CAS  Google Scholar 

  23. Yao KD, Peng T, Feng HB, He YY (1994) Swelling kinetics and release characteristic of crosslinked chitosan: polyether polymer network (semi-IPN) hydrogels. J Polym Sci A Polym Chem 32:1213–1223

    Article  CAS  Google Scholar 

  24. Almeria B, Deng WW, Fahmy TM, Gomez A (2010) Controlling the morphology of electrospray-generated PLGA microparticles for drug delivery. J Colloid Interface Sci 343:125–133

    Article  CAS  Google Scholar 

  25. Muthumanickkam A, Subramanian S, Goweri M, Beaula WS, Ganesh V (2013) Comparative study on eri silk and mulberry silk fibroin scaffolds for biomedical applications. Iran Polym J 22:143–154

    Article  CAS  Google Scholar 

  26. Song XF, Gao ZT, Ling FG, Chen XS (2012) Controlled release of drug via tuning electrospun polymer carrier. J Polym Sci B Polym Phys 50:221–227

    Article  CAS  Google Scholar 

  27. Huang X-J, Guduru D, Xu Z-K, Vienken J, Groth T (2011) Blood compatibility and permeability of heparin-modified polysulfone as potential membrane for simultaneous hemodialysis and LDL removal. Macromol Biosci 11:131–140

    Article  CAS  Google Scholar 

  28. Kumar KP, Paul W, Sharma CP (2011) Green synthesis of gold nanoparticles with Zingiber officinale extract: characterization and blood compatibility. Process Biochem 46:2007–2013

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The authors wish to acknowledge the financial support from (1) Jiangnan University scientific researches fund for doctoral students, (2) the Jiangsu Provincial Natural Science Foundation of China (No. BK2012112) and (3) the National Natural Science Foundation of China under Grant No. 31201134.

Author information

Authors and Affiliations

  1. Key Laboratory of Science and Technology of Eco-textiles, Ministry of Education, Jiangnan University, 214122, Wuxi, People’s Republic of China

    Jingwen Qin, Yanyan Jiang, Jiajia Fu, Yuqin Wan, Ruihua Yang, Weidong Gao & Hongbo Wang

Authors
  1. Jingwen Qin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yanyan Jiang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jiajia Fu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yuqin Wan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ruihua Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Weidong Gao
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Hongbo Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hongbo Wang.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Qin, J., Jiang, Y., Fu, J. et al. Evaluation of drug release property and blood compatibility of aspirin-loaded electrospun PLA/RSF composite nanofibers. Iran Polym J 22, 729–737 (2013). https://doi.org/10.1007/s13726-013-0171-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13726-013-0171-1

Keywords

Search

Navigation