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Diffuse large B-cell lymphoma, not otherwise specified presenting with bone and bone marrow involvement in the absence of lymphadenopathy

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Abstract

A 74-year-old woman visited our hospital because of right chest pain and fatigue. Laboratory examinations revealed pancytopenia and an elevated level of serum lactate dehydrogenase. Although bone lesions were detected by computed tomography, there was no lymphadenopathy. Blastoid cells were evident in the bone marrow. From the patient’s medical history and results of immunohistological and chromosomal analysis, she was diagnosed as having diffuse large B-cell lymphoma, not otherwise specified. This form of presentation of diffuse large B-cell lymphoma is very rare, and emphasizes the need for careful evaluation of such cases, including bone marrow biopsy for accurate diagnosis.

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References

  1. Campo E, Swerdlow SH, Harris NL et al (2011) The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications. Blood 117:5019–5032

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Harada S, Suzuki R, Uehira K et al (1999) Molecular and immunological dissection of diffuse large B cell lymphoma: CD5+, and CD5− with CD10+ groups may constitute clinically relevant subtypes. Leukemia 13:1441–1447

    Article  CAS  PubMed  Google Scholar 

  3. Matolcsy A, Chadburn A, Knowles DM (1995) De novo CD5-positive and Richter’s syndrome-associated diffuse large B cell lymphomas are genotypically distinct. Am J Pathol 147:207–216

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Swerdlow SH, Campo E, Harris NL et al (2008) WHO classification of tumours of haematopoietic and lymphoid tissues. IARC, Lyon

    Google Scholar 

  5. Yamaguchi M, Seto M, Okamoto M et al (2002) De novo CD5+ diffuse large B-cell lymphoma: a clinicopathologic study of 109 patients. Blood 99:815–821

    Article  CAS  PubMed  Google Scholar 

  6. Niitsu N, Okamoto M, Tamaru JI et al (2010) Clinicopathologic characteristics and treatment outcome of the addition of rituximab to chemotherapy for CD5-positive in comparison with CD5-negative diffuse large B-cell lymphoma. Ann Oncol 21:2069–2074

    Article  CAS  PubMed  Google Scholar 

  7. Miyazaki K, Yamaguchi M, Suzuki R et al (2011) CD5-positive diffuse large B-cell lymphoma: a retrospective study in 337 patients treated by chemotherapy with or without rituximab. Ann Oncol 22:1601–1607

    Article  CAS  PubMed  Google Scholar 

  8. Campbell J, Seymour JF, Matthews J et al (2006) The prognostic impact of bone marrow involvement in patients with diffuse large cell lymphoma varies according to the degree of infiltration and presence of discordant marrow involvement. Eur J Haematol 76:473–480

    Article  PubMed  Google Scholar 

  9. Moller MB, Pedersen NT, Christensen BE (2004) Diffuse large B-cell lymphoma: clinical implications of extranodal versus nodal presentation––a population-based study of 1575 cases. Br J Haematol 124:151–159

    Article  PubMed  Google Scholar 

  10. Conlan MG, Bast M, Armitage JO et al (1990) Bone marrow involvement by non-Hodgkin’s lymphoma: the clinical significance of morphologic discordance between the lymph node and bone marrow. Nebraska Lymphoma Study Group. J Clin Oncol 8:1163–1172

    CAS  PubMed  Google Scholar 

  11. Nakamura N, Kuze T, Hashimoto Y et al (2001) CD5-positive diffuse large B-cell lymphoma presenting in bone marrow without lymphadenopathy. J Clin Exp Hematopathol 41:73–80

    Article  Google Scholar 

  12. Mutreja D, Pati HP, Bansal D et al (2014) Aberrant immunophenotypic expression of CD5 in a case of B acute lymphoblastic leukemia: a case report. Indian J Hematol Blood Transfus 30:212–214

    Article  PubMed  PubMed Central  Google Scholar 

  13. Ohno H, Fukuhara S (1997) Significance of rearrangement of the BCL6 gene in B-cell lymphoid neoplasms. Leuk Lymphoma 27:53–63

    Article  CAS  PubMed  Google Scholar 

  14. Deucher AM, Qi Z, Yu J et al (2015) BCL6 expression correlates with the t(1;19) translocation in B-lymphoblastic leukemia. Am J Clin Pathol 143:547–557

    Article  PubMed  Google Scholar 

  15. Kramer MH, Hermans J, Wijburg E et al (1998) Clinical relevance of BCL2, BCL6, and MYC rearrangements in diffuse large B-cell lymphoma. Blood 92:3152–3162

    CAS  PubMed  Google Scholar 

  16. Kajiura D, Yamashita Y, Mori N (2007) Diffuse large B-cell lymphoma initially manifesting in the bone marrow. Am J Clin Pathol 127:762–769

    Article  PubMed  Google Scholar 

  17. Shimada K, Kinoshita T, Naoe T et al (2009) Presentation and management of intravascular large B-cell lymphoma. Lancet Oncol 10:895–902

    Article  PubMed  Google Scholar 

  18. Murase T, Yamaguchi M, Suzuki R et al (2007) Intravascular large B-cell lymphoma (IVLBCL): a clinicopathologic study of 96 cases with special reference to the immunophenotypic heterogeneity of CD5. Blood 109:478–485

    Article  CAS  PubMed  Google Scholar 

  19. Takahashi H, Tomita N, Yokoyama M et al (2012) Prognostic impact of extranodal involvement in diffuse large B-cell lymphoma in the rituximab era. Cancer 118:4166–4172

    Article  PubMed  Google Scholar 

  20. Sehn LH, Scott DW, Chhanabhai M et al (2011) Impact of concordant and discordant bone marrow involvement on outcome in diffuse large B-cell lymphoma treated with R-CHOP. J Clin Oncol 29:1452–1457

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine, Uwajima City Hospital, Goten-machi, Uwajima, Ehime, 798-8510, Japan

    Hisaharu Shikata, Masaki Maruta & Masahiko Kaneko

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  1. Hisaharu Shikata
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  2. Masaki Maruta
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  3. Masahiko Kaneko
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Correspondence to Hisaharu Shikata.

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None of the authors have any conflicts of interest to declare.

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Shikata, H., Maruta, M. & Kaneko, M. Diffuse large B-cell lymphoma, not otherwise specified presenting with bone and bone marrow involvement in the absence of lymphadenopathy. Int Canc Conf J 5, 183–186 (2016). https://doi.org/10.1007/s13691-016-0254-x

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  • DOI: https://doi.org/10.1007/s13691-016-0254-x

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