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A case of paraneoplastic liver dysfunction with elevated serum interleukin-6 in clinically localized renal cell carcinoma

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Abstract

We report a case of paraneoplastic liver dysfunction associated with a renal cell carcinoma, which disappeared after surgery. A 62-year-old male presented with fatigue and weight loss. The most prominent laboratory abnormality was elevated alkaline phosphatase, C-reactive protein, and interleukin-6 while normal aminotransferases. Computed tomography scan revealed a solid mass in the left kidney. A left radical nephrectomy was performed. After the surgery, biochemical abnormalities returned to normal.

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References

  1. Wein AJ, Kavoussi LR, Novick AC et al (2011) Campbell-Walsh Urology, 10th edn. Elsevier Health Sciences, Philadelphia

    Google Scholar 

  2. Giannakos G, Papanicolaou X, Trafalis D et al (2005) Stauffer’s syndrome variant associated with renal cell carcinoma. Int J Urol 12(8):757–759

    Article  PubMed  Google Scholar 

  3. Blay JY, Rossi JF, Wijdenes J et al (1997) Role of interleukin-6 in the paraneoplastic inflammatory syndrome associated with renal-cell carcinoma. Int J Cancer 72:424–430

    Article  PubMed  CAS  Google Scholar 

  4. Gold PJ, Fefer A, Thompson JA (1996) Paraneoplastic manifestations of renal cell carcinoma. Semin Urol Oncol 14:216–222

    PubMed  CAS  Google Scholar 

  5. Miki S, Iwano M, Miki Y et al (1989) Interleukin-6 (IL-6) functions as an in vitro autocrine growth factor in renal cell carcinomas. FEBS Lett 250:607–610

    Article  PubMed  CAS  Google Scholar 

  6. Chuang YC, Lin AT, Chen KK et al (1997) Paraneoplastic elevation of serum alkaline phosphatase in renal cell carcinoma: incidence and implication on prognosis. J Urol 158:1684–1687

    Article  PubMed  CAS  Google Scholar 

  7. Mortensen RF (2001) C-reactive protein, inflammation, and innate immunity. Immunol Res 24:163–176

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Urology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8525, Japan

    Kimiharu Takamatsu, Ryuichi Mizuno, Seiya Hattori, Hidaka Kono & Mototsugu Oya

  2. Division of Diagnostic Pathology, School of Medicine, Keio University, Tokyo, Japan

    Shuji Mikami

Authors
  1. Kimiharu Takamatsu
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  2. Ryuichi Mizuno
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  3. Seiya Hattori
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  4. Hidaka Kono
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  5. Shuji Mikami
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  6. Mototsugu Oya
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Corresponding author

Correspondence to Ryuichi Mizuno.

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Conflict of interest

The authors declare that they have no conflict of interest.

Research involving human subjects

All procedures performed in this report involving human participants were in accordance with the ethical standards of the institutional ethical committee.

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Takamatsu, K., Mizuno, R., Hattori, S. et al. A case of paraneoplastic liver dysfunction with elevated serum interleukin-6 in clinically localized renal cell carcinoma. Int Canc Conf J 5, 66–67 (2016). https://doi.org/10.1007/s13691-015-0229-3

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  • DOI: https://doi.org/10.1007/s13691-015-0229-3

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