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Differences in Weight Loss and Gut Hormones: Rouen-Y Gastric Bypass and Sleeve Gastrectomy Surgery

  • Obesity Treatment (CM Apovian, Section Editor)
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Abstract

Bariatric surgery is arguably the most effective therapy for weight loss, and Rouen-Y gastric bypass (RYGB) is considered the “gold-standard” procedure. However, sleeve gastrectomy (SG) surgery has become more prevalent in recent years and it is unclear if weight loss differences occur between these procedures. Herein, we discuss evidence from randomized clinical trials comparing the effectiveness of RYGB and SG on weight loss. Moreover, we highlight gut hormones (e.g., GLP-1, ghrelin, bile acids, etc.) as potentially important mechanisms that contribute to the durability of decreased appetite and opposed fat storage following RYGB and SG. Collectively, although a subtle (∼3–5 kg) weight loss difference may exist in favor of RYGB up to 3 years post-operation, it appears that RYGB and SG induce comparable weight loss and changes in gut physiology that parallel reduced disease risk. These findings are clinically relevant for optimizing treatment strategies that combat obesity-related diabetes and cardiovascular disease.

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Acknowledgments

SKM wrote the manuscript and SRK reviewed/edited the manuscript. Due to space limitations, the authors apologize for any article advancing knowledge of weight loss via RYGB and SG not included in this review.

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Conflict of Interest

Steven K. Malin and Sangeeta R. Kashyap declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Department of Kinesiology, University of Virginia, 210 Memorial Gymnasium, Charlottesville, VA, USA

    Steven K. Malin

  2. Division of Endocrinology and Metabolism, University of Virginia, 210 Memorial Gymnasium, Charlottesville, VA, USA

    Steven K. Malin

  3. Department of Endocrinology, Diabetes, and Metabolism, Cleveland Clinic, 9500 Euclid Ave (NE40), Cleveland, OH, 44195, USA

    Sangeeta R. Kashyap

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Correspondence to Sangeeta R. Kashyap.

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Malin, S.K., Kashyap, S.R. Differences in Weight Loss and Gut Hormones: Rouen-Y Gastric Bypass and Sleeve Gastrectomy Surgery. Curr Obes Rep 4, 279–286 (2015). https://doi.org/10.1007/s13679-015-0151-1

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