Abstract
Purpose of Review
The purpose of this review is to better understand the protein needs in patients with chronic kidney disease (CKD) not on dialysis. Protein energy wasting is common in patients with chronic kidney disease, and the incidence increases as the kidney function declines. Typically, protein intake in patients with CKD is lower than the daily-recommended allowance for healthy adults, and that poor nutritional status has been associated with increase in morbidity and mortality. It is of interest to note that the current guidelines for protein intake vary in terms of both quantity as well as the quality, thus making it confusing for the practicing nephrologist.
Recent Findings
Recent studies show that very low protein intake when supplemented by keto-analogues of essential amino acid could be helpful in slowing the progression of chronic kidney disease. However, it is important to understand that recommending low protein intake could be harmful in CKD patients especially those with poor nutritional status or during an acute illness.
Summary
In summary, it is important for the physician to understand that patients with chronic kidney disease have very complex nutritional requirements, and that recommendations for protein intake should be based on the individual patient needs.
Similar content being viewed by others
References
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
Trumbo P, Schlicker S, Yates AA, Poos M, Food, Nutrition Board of the Institute of Medicine TNA. RDA protein—dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein and amino acids. J Am Diet Assoc. 2002;102(11):1621–30.
• Pasiakos SM, Agarwal S, Lieberman HR, Fulgoni VL III. Sources and amounts of animal, dairy, and plant protein intake of US adults in 2007–2010. Nutrients. 2015;7(8):7058–69. This article presents data on the daily protein intake in healthy adults
• Delimaris I. Adverse effects associated with protein intake above the recommended dietary allowance for adults. ISRN Nutr. 2013;2013:126929. This article addresses the adverse effect of high protein diet in the healthy adults
• Schwingshackl L, Hoffmann G. Comparison of high vs. normal/low protein diets on renal function in subjects without chronic kidney disease: a systematic review and meta-analysis. PLoS One. 2014;9(5):e97656. This article compares the various protien intake in CKD
Ikizler TA, Greene JH, Wingard RL, Parker RA, Hakim RM. Spontaneous dietary protein intake during progression of chronic renal failure. J Am Soc Nephrol: JASN. 1995;6(5):1386–91.
Aguilera A, Codoceo R, Bajo MA, Iglesias P, Diez JJ, Barril G, et al. Eating behavior disorders in uremia: a question of balance in appetite regulation. Semin Dial. 2004;17(1):44–52.
Mitch WE. Cachexia in chronic kidney disease: a link to defective central nervous system control of appetite. J Clin Invest. 2005;115(6):1476–8.
•• Kovesdy CP, Kalantar-Zadeh K. Back to the future: restricted protein intake for conservative management of CKD, triple goals of renoprotection, uremia mitigation, and nutritional health. Int Urol Nephrol. 2016;48(5):725–9. Review article of effects on low protein diet in CKD
Riella MC. Nutritional evaluation of patients receiving dialysis for the management of protein-energy wasting: what is old and what is new? J Renal Nutr: Off J Council Renal Nutr Natl Kidney Found. 2013;23(3):195–8.
•• Kovesdy CP, Kopple JD, Kalantar-Zadeh K. Management of protein-energy wasting in non-dialysis-dependent chronic kidney disease: reconciling low protein intake with nutritional therapy. Am J Clin Nutr. 2013;97(6):1163–77. Review article discussion effects of low protein diet in CKD
Klahr S, Levey AS, Beck GJ, Caggiula AW, Hunsicker L, Kusek JW, et al. MDRD-BP and CKD. N Engl J Med. 1994;330(13):877–84.
Levey AS, Adler S, Caggiula AW, England BK, Greene T, Hunsicker LG, et al. MDRD—advanced renal disease. Am J Kidney Dis: Off J Natl Kidney Found. 1996;27(5):652–63.
Fouque D, Laville M, Meta-analysis 1. Cochrane review. Low protein diets for chronic kidney disease in non diabetic adults. Cochrane Database Syst Rev. 2009;3:CD001892.
• Jiang Z, Zhang X, Yang L, Li Z, Qin W. Meta-analysis 2—keto analogues in chronic kidney disease. Int Urol Nephrol. 2016;48(3):409–18. Meta-analysis of using keto-analog supplements in CKD
Kopple JD, Levey AS, Greene T, Chumlea WC, Gassman JJ, Hollinger DL, et al. MDRD—nutritonal status. Kidney Int. 1997;52(3):778–91.
Kopple JD. NKF K/DOQI guidelines for nutrition in chronic renal failure. Am J Kidney Dis: Off J Natl Kidney Found. 2001;37(1 Suppl 2):S66–70.
Cano NJ, Aparicio M, Brunori G, Carrero JJ, Cianciaruso B, Fiaccadori E, et al. ESPEN guidelines on parenteral nutrition: adult renal failure. Clin Nutr. 2009;28(4):401–14.
Brown RO, Compher C. American Society for P, Enteral Nutrition Board of D. ASPEN guidelines: nutrition support in adult acute and chronic renal failure. JPEN J Parenter Enteral Nutr. 2010;34(4):366–77.
• Ikizler TA, Cano NJ, Franch H, Fouque D, Himmelfarb J, Kalantar-Zadeh K, et al. IRSNM guidelines: prevention and treatment of protein energy wasting in chronic kidney disease patients: a consensus statement by the International Society of Renal Nutrition and Metabolism. Kidney Int. 2013;84(6):1096–107. ISRNM guidelines
Toigo G, Aparicio M, Attman PO, Cano N, Cianciaruso B, Engel B, et al. EWG? Expert working group report on nutrition in adult patients with renal insufficiency (part 1 of 2). Clin Nutr. 2000;19(3):197–207.
Hoffman JR, Falvo MJ. Protein—which is best? J sports sci med. 2004 Sep;3(3):118–30.
Shah AP, Kalantar-Zadeh K, Kopple JD. Review: ketoacid supplements in CKD? Am J Kidney Dis: Off J Natl Kidney Found. 2015;65(5):659–73.
•• Garneata L, Stancu A, Dragomir D, Stefan G, Mircescu G. Ketoanalogue-supplemented vegetarian very low-protein diet and CKD progression. J Am Soc Nephrol: JASN. 2016;27(7):2164–76. Study showing that very low protein when supplemented with keto-analogs of amino acid could slow progression of CKD
• Schulman G, Berl T, Beck GJ, Remuzzi G, Ritz E, Arita K, et al. EPPIC AST-120 in CKD-RCT. J Am Soc Nephrol: JASN. 2015;26(7):1732–46. Interesting article using the renal-gut axis to address issues with protien intake
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of Interest
Menaka Sarav, Catherine L. McKnight, and Carolyn A. Newberry declare they have no conflict of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Additional information
This article is part of the Topical Collection on Gastroenterology, Critical Care, and Lifestyle Medicine
Rights and permissions
About this article
Cite this article
Sarav, M., McKnight, C.L. & Newberry, C.A. Protein Intake in Chronic Kidney Disease. Curr Nutr Rep 6, 257–260 (2017). https://doi.org/10.1007/s13668-017-0213-y
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13668-017-0213-y