Abstract
Goreisan might be a medicine to cure the pain caused by thirst and dry mouth symptom of glossodynia. All registered patients were treated with Goreisan by taking 7.5 g / day (min 3) for 2 weeks. Self-filled Visual Analogue Scale (VAS) and tongue perception test by nomo-filament. Furthermore, daily self-filled VAS evaluation was required patients’ home for two weeks during Goreisan administration. There was 57% of patients (8/14) showed “improved” after administration of 2 weeks Goreisan administration based on the criteria of 20% reduction of VAS compared to baseline. Self-filled VAS score was significant low (p = 0.006) at 2 weeks evaluation at second visit and remained lower level through 4 week observation periods compared to baseline value. QST significantly increased after 2 weeks administration of Goreisan (p = 0.008) and remained higher level through 4 week observation periods compared to baseline value. There was significant reduction of daily self-filled VAS patients’ home at day 3 and day 13 ~ day 14. (p < 0.05). There is a weak positive and negative correlation between Barometric pressure (hPa) and self-filled VAS scale (cm) in each patients. The administration of Goreisan for two weeks lead to significant reduction of pain perception based on the evaluation of Self-filled pain scale (VAS) and tongue perception test (QST). There is correlation between barometric pressure and self-filled VAS scale. This fact might indicate that Goreisan would be the alternative treatment for glossodynia patients. Goreisan would be a successful alternative treatment modality for glossodynia patients.
Trial registration Current Controlled trials was registered with the UMIN Clinical Trials Registry (identifier: UMIN000035965, 02.21.2019).
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Abbreviations
- VAS:
-
Visual analogue scale
- QST:
-
Tongue quantitative sensory test
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Acknowledgements
We would like to express our deepest gratitude to Sawako Nakashima and Naoki Hosogaya. This work was supported by the institutional budget in Nagasaki University.
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The study was approved by the institutional review board of Nagasaki University, Nagasaki, Japan. Patients provided written informed consent after receiving a complete description of the study. This trial was registered with the University hospital Medical Information Network-Clinical Trials Registry (UMIN-CTR) (identifier: UMIN000035965).
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Ichiro Okayasu has no conflict of interest. Tachi Mizuki has no conflict of interest. Takuro Sanuki has no conflict of interest. Shinji Kurata has no conflict of interest. Takao Ayuse has no conflict of interest.
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The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
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Okayasu, I., Mizuki, T., Sanuki, T. et al. A pilot study of pain-relieving effect of Goreisan in glossodynia with dry mouth symptoms: an open-label single-group study. ADV TRADIT MED (ADTM) 21, 323–329 (2021). https://doi.org/10.1007/s13596-020-00441-x
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DOI: https://doi.org/10.1007/s13596-020-00441-x