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The effect of Rhus verniciflua Stokes (RVS) for anti-aging and whitening of skin

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Abstract

The purpose of this study is to investigate the effect of new materials from the traditional herbal medicines which induce anti-aging and anti-melanogenesis process of skin in vitro. Among 22 traditional herbal medicines which were tested in this study, Rhus vernciflua stokes (RVS) showed prominent effects for anti-aging and whitening of skin compared to other herbal extracts. In our study, RVS showed the highest elastase inhibitory effect and a higher anti-tyrosinase activity. Pretreatment with RVS significantly inhibited the expressions of UVB-induced MMP-1 protein and mRNA in a dose-dependent manner, and also inhibited the UV-induced activation of extracellular signal regulated kinase (ERK). In whitening, it was found that RVS significantly inhibits melanin biosynthesis in a dose-dependent manner. Moreover, α-MSH-induced increases of microphthalmia-associated transcription factor (MITF) and tyrosinase were significantly inhibited in B16F1 melanoma cells treated with RVS. Therefore, these data suggest that RVS extracts could be a potential agent for the prevention and treatment of skin photoaging and hyperpigmentation.

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Acknowledgments

This study was supported by a grant from Korean Medicine R&D project of the Ministry of Health and Welfare (B110043). This research was also supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (NRF-2012R1A1A3004797).

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The authors declare that they have no competing interests.

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Authors and Affiliations

  1. Laboratory of Clinical Biology and Pharmacogenomics and Center for Clinical Research and Genomics, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, 130-701, Republic of Korea

    Soo Hwa Kim, Hye-Sook Seo, Bo-Hyoung Jang, Yong-Cheol Shin & Seong-Gyu Ko

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  1. Soo Hwa Kim
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  2. Hye-Sook Seo
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  4. Yong-Cheol Shin
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Correspondence to Seong-Gyu Ko.

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Soo Hwa Kim and Hye-Sook Seo contributed equally to this work.

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Kim, S.H., Seo, HS., Jang, BH. et al. The effect of Rhus verniciflua Stokes (RVS) for anti-aging and whitening of skin. Orient Pharm Exp Med 14, 213–222 (2014). https://doi.org/10.1007/s13596-014-0152-8

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  • DOI: https://doi.org/10.1007/s13596-014-0152-8

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