References
Mendes CC, Zampieri BL, Arantes LMRB, et al. One-carbon metabolism and global DNA methylation in mothers of individuals with Down syndrome. Hum Cell. 2021. https://doi.org/10.1007/s13577-021-00586-0 (Online ahead of print. PMID: 34410622).
Zampieri BL, Biselli JM, Goloni-Bertollo EM, et al. Maternal risk for Down syndrome is modulated by genes involved in folate metabolism. Dis Markers. 2012;32:73–81.
Amorim MR, Moura CM, Gomes AD, et al. Betaine-homocysteine methyltransferase 742G>A polymorphism and risk of Down syndrome offspring in a Brazilian population. Mol Biol Rep. 2013;40:4685–9.
Jaiswal SK, Sukla KK, Chauhan A, et al. Choline metabolic pathway gene polymorphisms and risk for Down syndrome: an association study in a population with folate-homocysteine metabolic impairment. Eur J Clin Nutr. 2017;71:45–50.
Victorino DB, de Godoy MF, Goloni-Bertollo EM, et al. Genetic polymorphisms involved in folate metabolism and maternal risk for Down syndrome: a meta-analysis. Dis Markers. 2014;2014:12. https://doi.org/10.1155/2014/517504 (Article ID 517504).
Sae-Lee C, Biasi JD, Robinson N, et al. DNA methylation patterns of LINE-1 and Alu for pre-symptomatic dementia in type 2 diabetes. PLoS ONE. 2020;15(6): e0234578. https://doi.org/10.1371/journal.pone.0234578.
Kim K, Friso S, Choi S-W. DNA methylation, an epigenetic mechanism connecting folate to healthy embryonic development and aging. J Nutr Biochem. 2009;20:917–26. https://doi.org/10.1016/j.jnutbio.2009.06.008.
Author information
Authors and Affiliations
Corresponding author
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Amorim, M.R., Lima, M.A.C. Are we getting closer to the role of one-carbon metabolism and methylation in the onset of Down syndrome?. Human Cell 35, 421–422 (2022). https://doi.org/10.1007/s13577-021-00631-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13577-021-00631-y