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Place et modalités de la sédation au cours de la ventilation non invasive

Place and modalities of sedation during non-invasive ventilation

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Réanimation

Résumé

Le confort du patient sous ventilation non invasive (VNI) est une des clés majeures de la réussite de cette technique de support ventilatoire. Malgré l’optimisation des interfaces, des réglages et des paramètres ventilatoires, un certain nombre de patients doivent être intubés du fait de leur intolérance à la VNI. Même si l’usage d’agents sédatifs est fréquemment rapporté dans la littérature, seuls quelques travaux prospectifs proposent des protocoles de sédation adaptés à cette situation. Sous couvert de précautions strictes, avec des produits d’action courte et idéalement administrés en « objectif de concentration », la sédation semble pouvoir être envisagée afin de permettre la poursuite de la VNI en cas d’intolérance, permettant ainsi de diminuer l’incidence du recours à l’intubation. L’objectif de la sédation n’est pas de retarder une intubation rendue nécessaire du fait de l’état du patient, mais bien de permettre la poursuite de la VNI en cas d’intolérance ou d’inconfort majeur du patient.

Abstract

One major key of success of non-invasive ventilation (NIV) is the patient’s comfort. Despite the optimization of interfaces, settings, and ventilatory parameters, some patients have to be intubated because of low NIV tolerance. Adapted sedation can overcome this difficulty, aiming to reduce intubation incidence. Even if the use of sedative agents is frequently reported in the literature, only a few prospective studies have tested sedation protocols adapted to this situation. Administration of drugs with rapid onset and short duration of action, using target-controlled infusion should avoid NIV failure due to patient’s intolerance. Sedation objective is not to delay intubation but rather to allow NIV continuation in case of intolerance or major discomfort.

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Références

  1. Brochard L, Mancebo J, Wysocki M, et al (1995) Non-invasive ventilation for acute execerbation of chronic obstructive pulmonary disease. N Engl J Med 333:817–822

    Article  PubMed  CAS  Google Scholar 

  2. Nava S, Carbone G, Dibattista N, et al (2003) Non-invasive ventilation in cardiogenic pulmonary oedema: a multicenter randomized trial. Am J Respir Crit Care Med 168:1432–1437

    Article  PubMed  Google Scholar 

  3. Masip J, Betbese AJ, Paez J, et al (2000) Non-invasive pressure support ventilation versus conventional oxygen therapy in acute cardiogenic pulmonary oedema: a randomised trial. Lancet 356:2126–2132

    Article  PubMed  CAS  Google Scholar 

  4. Hilbert G, Gruson D, Vargas F, et al (2003) Non-invasive ventilation in immunosuppressed patients. Rev Mal Respir 20:68–76

    PubMed  CAS  Google Scholar 

  5. Antonelli M, Conti G, Moro ML, et al (2001) Predictors of failure of non-invasive positive pressure ventilation in patients with acute hypoxemic respiratory failuire: a multicenter study. Intensive Care Med 27:1718–1728

    Article  PubMed  CAS  Google Scholar 

  6. Delclaux C, L’Her E, Alberti C, et al (2000) Treatment of acute hypoxemic nonhypercapnic respiratory insufficiency with continuous positive airway pressure delivered by a face mask. A randomized controlled trial. JAMA 284:2352–2360

    Article  PubMed  CAS  Google Scholar 

  7. Carlucci ARJ, Wysocki M, Lepage E, Brochard L (2001) Non-invasive versus conventional mechanical ventilation. An epidemiologic survey. Am J Respir Crit Care Med 163:874–880

    PubMed  CAS  Google Scholar 

  8. Rocco M, Conti G, Alessandri E, et al (2010) Rescue treatment for non-invasive ventilation failure due to interface intolerance with remifentanil analgosedation: a pilot study. Intensive Care Med 36:2060–2065

    Article  PubMed  Google Scholar 

  9. SFAR, SPLF, SRLF (2006) Ventilation non invasive au cours de l’insuffisance respiratoire aiguë (nouveau-né exclu). In: 3e Conférence de consensus commune, Paris. http://www.srlf.org/Data/ModuleGestionDeContenu/application/708.pdf

  10. Devlin J, Nava S, Bahhady I, Hill N (2007) Survey sedation practices during non-invasive positive-pressure ventilation to treat acute respiratory failure. Crit Care Med 35:2298–2302

    Article  PubMed  Google Scholar 

  11. Rocker G, Mackenzie M, Williams B, Logan P (1999) Noninvasive Positive Pressure ventilation: successful outcome in patients with acute lung injury/ARDS. Chest 115:173–177

    Article  PubMed  CAS  Google Scholar 

  12. Masip J (2007) Non-invasive ventilation. Heart Fail Rev 12:119–124

    Article  PubMed  Google Scholar 

  13. Nunes P, Abadesso C, Almeida E, et al (2010) Non-invasive ventilation in a pediatric intensive care unit. Acta Med Portuguese 3:399–404

    Google Scholar 

  14. Codazzi D, Nacoti M, Passoni M, et al (2006) Continuous positive airway pressure with modified Helmet for treatment of hypoxemic acute respiratory failure in infants and preschool population: a feasibility study. Ped Crit Care Med 7:495–496

    Article  Google Scholar 

  15. Akada S, Takeda S, Yoshida Y, Sakamato A (2008) The efficacy of dexmedetomidine in patients with non-invasive ventilation: a preliminary study. Anesth Analg 107:167–170

    Article  PubMed  CAS  Google Scholar 

  16. Constantin J, Schneider E, Cayot-Constantin S, et al (2007) Remifentanil-based sedation to treat non-invasive failure: a preliminary study. Intensive Care Med 33:82–87

    Article  PubMed  CAS  Google Scholar 

  17. Clouzeau B, Bui HN, Vargas F, et al (2010) Target-controlled infusion of propofol for sedation in patients with non-invasive ventilation failure due to low tolerance: a preliminary study. Intensive Care Med 36:1675–1680

    Article  PubMed  CAS  Google Scholar 

  18. Sessler C, Gosnell M, Grap M, et al (2002) The Richemond Agitation-Sedation Scale: validity and reliability in adult intensive care unit patients. Am J Respir Crit Care Med 1338-44

  19. Ramsay MA, Savege TM, Simpson BR, Goodwin R (1974) Controlled sedation with alphaxalone-alphadolone. BMJ 2:656–659

    Article  PubMed  CAS  Google Scholar 

  20. Antonelli M, Conti G, Esquinas A, et al (2007) A multiple center survey on the use in clinical practice of non-invasive ventilation as a first-line intervention for acute respiratory distress syndrome. Crit Care Med 35:18–25

    Article  PubMed  Google Scholar 

  21. Chernik DA, Gillings D, Laine H, et al (1990) Validity and reliability of the Observer’s Assessment of Alertness/Sedation Scale: study with intravenous midazolam. J Clin Psychopharmacol 10:244–251

    Article  PubMed  CAS  Google Scholar 

  22. Clouzeau B, Grenouillet M, Bui H, et al (2008) Feasability and safety of fiberoptic bronchoscopy with bronchoalveolar lavage under NIV with propofol target controlled infusion in patient with acute hypoxemic failure. Intensive Care Med 34(Suppl 1): S76–S81

    Google Scholar 

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Correspondence to B. Clouzeau.

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Clouzeau, B., Vargas, F., Boyer, A. et al. Place et modalités de la sédation au cours de la ventilation non invasive. Réanimation 20, 389–396 (2011). https://doi.org/10.1007/s13546-011-0283-6

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  • DOI: https://doi.org/10.1007/s13546-011-0283-6

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