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Plasma Homocysteine level and its clinical correlation with type 2 diabetes mellitus and its complications

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Abstract

Homocysteine (Hcys) has been implicated to be associated with diabetes and its complications. To study the association of plasma Hcys with diabetes complications (cardiovascular disease [CVD], cerebrovascular disease [CBVD], peripheral vascular disease [PVD], nephropathy, retinopathy and neuropathy). 316 type 2 diabetic patients were enrolled for the study. Plasma Hcys was done by Chemiluminescence Micropart assay. Elevated plasma Hcys correlated significantly with duration of the disease, CVD, CBVD, PVD, Nephropathy, Retinopathy and Neuropathy showed significant association with abnormal plasma Hcys level. Total cholesterol and triglyceride was significantly associated with abnormal plasma Hcys level. However Hb1Ac, LDL and HDL did not show significant correlation. Plasma Hcys level can be considered as an early marker of progression of diabetes and its complications.

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Acknowledgments

The authors are thankful to the laboratory technical staff of King George’s Medical University, (Formerly C.S.M. Medical University) Lucknow, India for the help and cooperation in carrying out this work.

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Authors and Affiliations

  1. Hemodialysis Unit, Department of Medicine, King George’s Medical University, UP, Lucknow, India

    Satyendra Kumar Sonkar, Deepika Soni, Dheeraj Soni & Kauser Usman

  2. Department of Biochemistry, King George’s Medical University, UP, Lucknow, India

    Gyanendra Kumar Sonkar

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  1. Satyendra Kumar Sonkar
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  2. Gyanendra Kumar Sonkar
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Correspondence to Satyendra Kumar Sonkar.

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Sonkar, S.K., Sonkar, G.K., Soni, D. et al. Plasma Homocysteine level and its clinical correlation with type 2 diabetes mellitus and its complications. Int J Diabetes Dev Ctries 34, 3–6 (2014). https://doi.org/10.1007/s13410-013-0154-y

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  • DOI: https://doi.org/10.1007/s13410-013-0154-y

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