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Frequency of varicella zoster virus DNA in human adrenal glands

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A Correction to this article was published on 01 August 2023

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Abstract

Varicella zoster virus (VZV) becomes latent in ganglionic neurons derived from neural crest cells. Because the adrenal gland also contains medullary chromaffin cells of neural crest origin, we examined human adrenal glands and medullary chromaffin cell tumors (pheochromocytomas) for VZV and herpes simplex virus type 1 (HSV-1). We found VZV, but not HSV-1, DNA in 4/63 (6 %) normal adrenal glands. No VZV transcripts or antigens were detected in the 4 VZV DNA-positive samples. No VZV or HSV-1 DNA was found in 21 pheochromocytomas.

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Acknowledgments

This work was supported by Public Health Service grants AG032958 (D.G., M.A.N.), NS093716 (D.G.), and NS094758 (M.A.N.) from the National Institutes of Health. Hussain Badani was supported by training grant NS007321 to D.G. from the National Institutes of Health. We thank Marina Hoffman for editorial review and Cathy Allen for manuscript preparation.

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Authors and Affiliations

  1. Department of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Box B-182, Aurora, CO, 80045, USA

    Hussain Badani, Teresa White, Nicole Schulick, Ibrahim Topkaya, Don Gilden & Maria A. Nagel

  2. Department of Immunology and Microbiology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Box B-182, Aurora, CO, 80045, USA

    Don Gilden

  3. Department of Surgery, University of Colorado School of Medicine, 12631 E. 17th Avenue, Box C-305, Aurora, CO, 80045, USA

    Christopher D. Raeburn

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  1. Hussain Badani
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  2. Teresa White
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  3. Nicole Schulick
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  4. Christopher D. Raeburn
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  5. Ibrahim Topkaya
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  6. Don Gilden
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  7. Maria A. Nagel
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Correspondence to Maria A. Nagel.

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Badani, H., White, T., Schulick, N. et al. Frequency of varicella zoster virus DNA in human adrenal glands. J. Neurovirol. 22, 400–402 (2016). https://doi.org/10.1007/s13365-016-0425-8

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  • DOI: https://doi.org/10.1007/s13365-016-0425-8

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