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Research progress on nanotechnology of traditional Chinese medicine to enhance the therapeutic effect of osteoarthritis

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Abstract

Osteoarthritis (OA) is a prevalent chronic condition that primarily impacts the articular cartilage and surrounding bone tissue, resulting in joint inflammation and structural deterioration. The etiology of OA is multifaceted and intricately linked to the oxidative stress response of joint tissue. Oxidative stress (OS) in OA leads to the creation of reactive oxygen species (ROS) and other oxidizing agents, resulting in detrimental effects on chondrocytes. This oxidative damage diminishes the flexibility and robustness of cartilage, thereby expediting the progression of joint deterioration. Therefore, the antioxidant effect is crucial in the treatment of OA. Currently, a considerable number of components found in traditional Chinese medicine (TCM) have been scientifically demonstrated to exhibit remarkable antioxidant and anti-inflammatory properties. Nevertheless, the utilization of this program is considerably constrained as a result of intrinsic deficiencies, notably stability concerns. The successful amalgamation of TCM components with nanotechnology has properly tackled these concerns and enhanced the efficacy of therapeutic results. The objective of this study is to delineate the antioxidant characteristics of nano-TCM and assess the current inventory of literature pertaining to the application of nano-TCM in the treatment of OA. In conclusion, this paper will now turn to the constraints and potential avenues for the advancement of nano-TCM within the realm of OA therapy.

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Acknowledgements

All authors have conveyed their sincere gratitude to scientists and researchers who had worked in nano-traditional Chinese medicine and contributed their valuable results in the literature. All authors expressed their sincere thanks to all the expert reviewers for their valuable time and suggestions for shaping up this manuscript.

Funding

This study was funded by the National Nature Science Foundation of China (Grant No. 81860256) and the Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China (Grant No. 171098).

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  1. Yue Peng and Zhengshuang Yang contributed equally.

Authors and Affiliations

  1. Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed By the Province and Ministry, Guangxi Key Laboratory of Regenerative Medicine & Key Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of Education, Guangxi Medical University, Shuangyong Road, 530021, Nanning, Guangxi, People’s Republic of China

    Yue Peng, Zhengshuang Yang & Sijia Liu

  2. Guangxi Colleges and Universities Key Laboratory of Biological Molecular Medicine Research, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Guangxi Medical University, Shuangyong Road, 530021, Nanning, Guangxi, People’s Republic of China

    Yue Peng, Zhengshuang Yang, Jinling Li & Sijia Liu

  3. Laboratory of Basic Medicine Center, Guangxi Medical University, Shuangyong Road, 530021, Nanning, Guangxi, People’s Republic of China

    Jinling Li

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SL had the idea for the article, YP and ZY performed the literature and wrote the first draft of the manuscript, and JL critically revised the work. YP and ZY contributed equally to this work. All authors read and approved the final manuscript.

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Peng, Y., Yang, Z., Li, J. et al. Research progress on nanotechnology of traditional Chinese medicine to enhance the therapeutic effect of osteoarthritis. Drug Deliv. and Transl. Res. 14, 1517–1534 (2024). https://doi.org/10.1007/s13346-024-01517-w

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