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Diabetic ketoacidosis in a patient with acromegaly and central diabetes insipidus treated with octreotide long-acting release

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Abstract

A 43-year-old man was diagnosed with acromegaly due to pituitary GH-secreting macroadenoma, and underwent craniotomy surgery. After surgery, he was given octreotide long-acting release (LAR) to treat the residual tumor. Eighteen months later, he presented polydipsia and polyuria due to diabetic ketoacidosis (DKA) and central diabetes insipidus (CDI). His casual plasma glucose level was 570 mg/dL, his HbA1c was 14.9%, and his urine was strongly positive for ketone bodies. We discuss a causal relationship among DKA, CDI, and treatment with LAR in this case with residual GH-secreting tumor from the perspective of insulin secretion and resistance.

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Authors and Affiliations

  1. The First Department of Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama, Japan

    Hidefumi Inaba, Tomomi Funahashi, Hiroyuki Ariyasu, Hiroshi Iwakura, Hiroto Furuta, Masahiro Nishi & Takashi Akamizu

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  1. Hidefumi Inaba
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  2. Tomomi Funahashi
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  3. Hiroyuki Ariyasu
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  4. Hiroshi Iwakura
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  5. Hiroto Furuta
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  6. Masahiro Nishi
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  7. Takashi Akamizu
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Correspondence to Hidefumi Inaba.

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All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions. Informed consent or a substitute for it was obtained from all patients before they were included in the report.

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Inaba, H., Funahashi, T., Ariyasu, H. et al. Diabetic ketoacidosis in a patient with acromegaly and central diabetes insipidus treated with octreotide long-acting release. Diabetol Int 8, 237–242 (2017). https://doi.org/10.1007/s13340-016-0301-z

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  • DOI: https://doi.org/10.1007/s13340-016-0301-z

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