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Crimean-Congo hemorrhagic fever cases in the North of Iran have three distinct origins

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Abstract

An on-going surveillance program on Crimean-Congo haemorrhagic fever virus (CCHFV) in Iran has been launched since 2000. An outbreak of CCHF occurred in northern Iran between June and July 2015. Three cases were involved in this outbreak. One patient died after admission to hospital, and the others were treated successfully. Phylogenetic analysis showed that three sequences obtained from Iranian patients grouped within clade IV (Asia-1), clade V (Europe) and clade VI (Greece). The partial sequence of the strain Noshahr59 (KT588642) showed the highest similarity with other strains isolated from Russia, Kosovo and Turkey (Clade V, Europe). The genome sequence of the strain Chalous65 (KT588640) showed 100% homology to the strain AP29 isolated from Greece (DQ211638). The genome sequence of the strain Noshahr43 (KT588641) showed 88% similarity to the Pakistani and previously reported Iranian strains (AF527810, AJ538198, AY366379 and AY366373). These data support previous studies, which showed a distinct similarity between Iranian S segments of CCHFV strains with other strains within clade IV (Asia-1) and clade V (Europe). In addition, clade VI was detected for the first time in Iran. Moreover, strain Chalous65 with similar genetic characteristics to strain AP29 from Greece was isolated from a fatal human case.

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References

  1. Biglari P, Chinikar S, Belqeiszadeh H, Telmadarraiy Z, Mostafavi E, Ghaffari M, et al. Phylogeny of tick-derived Crimean-Congo hemorrhagic fever virus strains in Iran. Ticks Tick Borne Dis. 2016;7:1216–21.

    Article  PubMed  Google Scholar 

  2. Champour M, Chinikar S, Mohammadi G, Razmi G, Shah-Hosseini N, Khakifirouz S, et al. Molecular epidemiology of Crimean–Congo hemorrhagic fever virus detected from ticks of one humped camels (Camelus dromedarius) population in northeastern Iran. J Parasit Dis. 2014;40:110–115.

  3. Champour M, Mohammadi GR, Chinikar S, Razmi G, Shah-Hosseini N, Khakifirouz S, et al. Seroepidemiology of Crimean-Congo hemorrhagic fever virus in one-humped camels (Camelus dromedarius) population in northeast of Iran. J Vector Borne Dis. 2014;51:62–5.

    PubMed  Google Scholar 

  4. Chinikar S, Ghiasi SM, Naddaf S, Piazak N, Moradi M, Razavi MR, et al. Serological evaluation of Crimean-Congo hemorrhagic fever in humans with high-risk professions living in enzootic regions of Isfahan Province of Iran and genetic analysis of circulating strains. Vector Borne Zoonotic Dis. 2012;12:733–8.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Chinikar S, Shayesteh M, Khakifirouz S, Jalali T, Rasi Varaie FS, Rafigh M, et al. Nosocomial infection of Crimean-Congo haemorrhagic fever in eastern Iran: case report. Travel Med Infect Dis. 2013;11:252–5.

    Article  PubMed  Google Scholar 

  6. Chinikar S, Shah-Hosseini N, Bouzari S, Jalali T, Shokrgozar MA, Mostafavi E. New circulating genomic variant of Crimean-Congo hemorrhagic fever virus in Iran. Arch Virol. 2013;158:1085–8.

    Article  CAS  PubMed  Google Scholar 

  7. Chinikar S, Shah-Hosseini N, Bouzari S, Shokrgozar MA, Mostafavi E, Jalali T, et al. Assessment of recombination in the S-segment genome of Crimean-Congo hemorrhagic fever virus in Iran. J Arthropod Borne Dis. 2016;10:12–23.

    PubMed  Google Scholar 

  8. Chinikar S, Bouzari S, Shokrgozar MA, Mostafavi E, Jalali T, Khakifirouz S, et al. Genetic diversity of Crimean Congo hemorrhagic fever virus strains from Iran. J Arthropod Borne Dis. 2016;10:127–40.

    PubMed  PubMed Central  Google Scholar 

  9. Farhadpour F, Telmadarraiy Z, Chinikar S, Akbarzadeh K, Moemenbellah-Fard M, Faghihi F, et al. Molecular detection of Crimean-Congo haemorrhagic fever virus in ticks collected from infested livestock populations in a New Endemic Area, South of Iran. Trop Med Int Health. 2016;21:340–7.

    Article  CAS  PubMed  Google Scholar 

  10. Kayedi MH, Chinikar S, Mostafavi E, Khakifirouz S, Jalali T, Hosseini-Chegeni A, et al. Crimean-Congo hemorrhagic fever virus clade IV (Asia 1) in ticks of Western Iran. J Med Entomol. 2015;52:1144–9.

    Article  PubMed  Google Scholar 

  11. Mehravaran A, Moradi M, Telmadarraiy Z, Mostafavi E, Moradi AR, Khakifirouz S, et al. Molecular detection of Crimean-Congo haemorrhagic fever (CCHF) virus in ticks from southeastern Iran. Ticks Tick Borne Dis. 2013;4:35–8.

    Article  PubMed  Google Scholar 

  12. Mohammadian M, Chinikar S, Telmadarraiy Z, Vatandoost H, Oshaghi MA, Hanafi-Bojd AA, et al. Molecular assay on crimean congo hemorrhagic fever virus in ticks (ixodidae) collected from Kermanshah Province, Western Iran. J Arthropod Borne Dis. 2016;10:383–93.

    Google Scholar 

  13. Papa A, Dalla V, Papadimitriou E, Kartalis G, Antoniadis A. Emergence of Crimean-Congo haemorrhagic fever in Greece. Clin Microbiol Infect. 2010;16:843–7.

    Article  CAS  PubMed  Google Scholar 

  14. Whitehouse CA. Crimean-Congo hemorrhagic fever. Antivir Res. 2004;64:145–60.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgement

We thank all technical assistance for laboratory analysis.

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Authors and Affiliations

  1. WHO Collaborating Centre for Arbovirus and Haemorrhagic Fever Reference and Research, Department of Virology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359, Hamburg, Germany

    Nariman Shahhosseini

  2. Pasteur Institute of Iran, Tehran, Iran

    Sadegh Chinikar & Elnaz Shams

  3. Institute of Virology, University of Veterinary Medicine, Vienna, Austria

    Norbert Nowotny

  4. Department of Basic Medical Sciences, College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates

    Norbert Nowotny

  5. Wildlife Zoonoses and Vector-borne Diseases Research Group, Animal and Plant Health Agency, Woodham Lane, New Haw, Surrey, KT15 3NB, UK

    Anthony R. Fooks

  6. Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, Liverpool, UK

    Anthony R. Fooks

Authors
  1. Nariman Shahhosseini
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  2. Sadegh Chinikar
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  3. Elnaz Shams
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  4. Norbert Nowotny
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  5. Anthony R. Fooks
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Corresponding author

Correspondence to Nariman Shahhosseini.

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Shahhosseini, N., Chinikar, S., Shams, E. et al. Crimean-Congo hemorrhagic fever cases in the North of Iran have three distinct origins. VirusDis. 28, 50–53 (2017). https://doi.org/10.1007/s13337-016-0359-z

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  • DOI: https://doi.org/10.1007/s13337-016-0359-z

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