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Identification of Naringin Metabolites in Human Urine and Feces

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European Journal of Drug Metabolism and Pharmacokinetics Aims and scope Submit manuscript

Abstract

Background and Objectives

Naringin, an active flavanone glycoside, has been widely considered as a prospective antitussive and expectorant. The present study aimed to elucidate the metabolic profile of naringin in the human body.

Methods

Four male and three female volunteers (20–30 years old and 18.8–21.7 kg/m2 Body Mass Index) were orally administrated 320 mg naringin; their urine and feces were collected at different times and the corresponding metabolites were identified with a high resolution ultra-fast liquid chromatography-quadrupole-time-of-flight tandem mass spectrometry (UFLC-Q-TOF–MS/MS) system.

Results

Sixteen conjugative metabolites and five polyphenols were identified. These detected metabolites varied in the types, relative responses, and excretion times among different individuals.

Conclusions

The results revealed that naringin underwent extensive phase II metabolism in the human body and yielded an array of conjugated products. This study provided a reference for further clinical studies and in vivo metabolism of other flavonoids.

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Acknowledgments

This work was financial supported by the fund of National Major Scientific and Technical Special Project of China (No. 2015ZX09101014), National Natural Science Foundation of China (No. 81374041), and Applied Science and Technology R&D Special Fund Project of Guangdong Province (No. 2015B020234004).

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Authors and Affiliations

  1. State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Plant Resources, Guangdong Engineering & Technology Research Center for Quality and Efficacy Re-evaluation of Post-market Traditional Chinese Medicine, School of Life Sciences, Sun Yat-sen University, No. 135, Xingang Xi Road, Guangzhou, 510275, People’s Republic of China

    Xuan Zeng, Yang Bai, Wei Peng & Weiwei Su

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  1. Xuan Zeng
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  2. Yang Bai
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  3. Wei Peng
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  4. Weiwei Su
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Correspondence to Weiwei Su.

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All the authors declare that there are no known conflicts of interest with this publication.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This study was conducted with the authorization of the Ethics Committee of the School of Life Science, Sun Yat-sen University, Guangzhou 510275, P.R. China.

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Informed consent was obtained from all individual participants included in the study.

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Zeng, X., Bai, Y., Peng, W. et al. Identification of Naringin Metabolites in Human Urine and Feces. Eur J Drug Metab Pharmacokinet 42, 647–656 (2017). https://doi.org/10.1007/s13318-016-0380-z

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  • DOI: https://doi.org/10.1007/s13318-016-0380-z

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