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INCLEN diagnostic tool for epilepsy (INDT-EPI) for primary care physicians: Development and validation

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Abstract

Objective

To evaluate the diagnostic accuracy of a new diagnostic instrument for epilepsy — INCLEN Diagnostic Tool for Epilepsy (INDT-EPI) — with evaluation by expert pediatric neurologists.

Study design

Evaluation of diagnostic test.

Setting

Tertiary care pediatric referral centers in India.

Methods

Children aged 2–9 years, enrolled by systematic random sampling at pediatric neurology out-patient clinics of three tertiary care centers were independently evaluated in a blinded manner by primary care physicians trained to administer the test, and by teams of two pediatric neurologists.

Outcomes

A 13-item questionnaire administered by trained primary care physicians (candidate test) and comprehensive subject evaluation by pediatric neurologists (gold standard).

Results

There were 240 children with epilepsy and 274 without epilepsy. The candidate test for epilepsy had sensitivity and specificity of 85.8% and 95.3%; positive and negative predictive values of 94.0% and 88.5%; and positive and negative likelihood ratios of 18.25 and 0.15, respectively.

Conclusion

The INDT-EPI has high validity to identify children with epilepsy when used by primary care physicians.

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Authors and Affiliations

  1. INCLEN Trust International, F1/5, Okhla Industrial Area, Phase-1, New Delhi, India

    Ramesh Konanki, Devendra Mishra, Sheffali Gulati, Satinder Aneja, Vaishali Deshmukh, Donald Silberberg, Jennifer M. Pinto, Maureen Durkin, Ravindra M. Pandey, M. K. C. Nair & Narendra K. Arora

Authors
  1. Ramesh Konanki
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  2. Devendra Mishra
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  3. Sheffali Gulati
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  4. Satinder Aneja
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  5. Vaishali Deshmukh
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  6. Donald Silberberg
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  7. Jennifer M. Pinto
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  8. Maureen Durkin
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  9. Ravindra M. Pandey
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  10. M. K. C. Nair
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  11. Narendra K. Arora
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Consortia

INCLEN Study Group

Corresponding author

Correspondence to Narendra K. Arora.

Additional information

INCLEN Study Group: Core Group: Alok Thakkar, Arun Singh, Gautam Bir Singh, Manju Mehta, Manoja K Das, Monica Juneja, Nandita Babu, Paul SS Russell, Poma Tudu, Praveen Suman, Rajesh Sagar, Rohit Saxena, Savita Sapra, Sharmila Mukherjee, Sunanda K Reddy, Tanuj Dada, Vinod Bhutani. Extended Group: AK Niswade, Archisman Mohapatra, Arti Maria, Atul Prasad, BC Das, Bhadresh Vyas, GVS Murthy, Gourie M Devi, Harikumaran Nair, JC Gupta, KK Handa, Leena Sumaraj, Madhuri Kulkarni, Muneer Masoodi, Poonam Natrajan, Rashmi Kumar, Rashna Dass, Rema Devi, Sandeep Bavdekar, Santosh Mohanty, Saradha Suresh, Shobha Sharma, Sujatha S Thyagu, Sunil Karande, TD Sharma, Vinod Aggarwal, Zia Chaudhuri.

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Konanki, R., Mishra, D., Gulati, S. et al. INCLEN diagnostic tool for epilepsy (INDT-EPI) for primary care physicians: Development and validation. Indian Pediatr 51, 539–543 (2014). https://doi.org/10.1007/s13312-014-0443-7

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  • DOI: https://doi.org/10.1007/s13312-014-0443-7

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