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Revised guidelines on management of antenatal hydronephrosis

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Abstract

Widespread antenatal screening has resulted in increased detection of anomalies of the kidneys and urinary tract. The present guidelines update the recommendations published in 2000. Antenatal hydronephrosis (ANH) is transient and resolves by the third trimester in almost one-half cases. The presence of oligohydramnios and additional renal or extrarenal anomalies suggests significant pathology. All patients with ANH should undergo postnatal ultrasonography; the intensity of subsequent evaluation depends on anteroposterior diameter (APD) of the renal pelvis and/or Society for Fetal Urology (SFU) grading. Patients with postnatal APD exceeding 10 mm and/or SFU grade 3–4 should be screened for upper or lower urinary tract obstruction and vesicoureteric reflux. Infants with vesicoureteric reflux should receive antibiotic prophylaxis through the first year of life, and their parents counseled regarding the risk of urinary tract infections. The management of patients with pelviureteric junction or vesicoureteric junction obstruction depends on clinical features and results of sequential ultrasonography and radionuclide renography. Surgery is considered in patients with increasing renal pelvic APD and/or an obstructed renogram with differential renal function <35–40% or its subsequent decline. Further studies are necessary to clarify the role of prenatal intervention, frequency of follow up investigations and indications for surgery in these patients.

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References

  1. Mallik M, Watson AR. Antenatally detected urinary tract abnormalities: more detection but less action. Pediatr Nephrol. 2008;23:897–904.

    Article  PubMed  Google Scholar 

  2. Dudley JA, Haworth JM, McGraw ME, Frank JD, Tizard EJ. Clinical relevance and implications of antenatal hydronephrosis. Arch Dis Child Fetal Neonatal Ed. 1997;76:F31–F34.

    Article  PubMed  CAS  Google Scholar 

  3. Kim EK, Song TB. A study on fetal urinary tract anomaly: antenatal ultrasonographic diagnosis and postnatal follow-up. J Obstet Gynaecol Res. 1996;22:569–573.

    PubMed  CAS  Google Scholar 

  4. Ek S, Lidefeldt KJ, Varricio L. Fetal hydronephrosis; prevalence, natural history and postnatal consequences in an unselected population. Acta Obstet Gynecol Scand. 2007;86:1463–1466.

    Article  PubMed  Google Scholar 

  5. Livera LN, Brookfield DS, Egginton JA, Hawnaur JM. Antenatal ultrasonography to detect fetal renal abnormalities: a prospective screening programme. BMJ. 1989;298:1421–1423.

    Article  PubMed  CAS  Google Scholar 

  6. Sairam S, Al-Habib A, Sasson S, Thilaganathan B. Natural history of fetal hydronephrosis diagnosed on mid-trimester ultrasound. Ultrasound Obstet Gynecol. 2001;17:191–196.

    Article  PubMed  CAS  Google Scholar 

  7. Lee RS, Cendron M, Kinnamon DD, Nguyen HT. Antenatal hydronephrosis as a predictor of postnatal outcome: a metaanalysis. Pediatrics. 2006;118:586–593.

    Article  PubMed  Google Scholar 

  8. de Kort EHM, Bambang Oetomo S, Zegers SH. The long term outcome of antenatal hydronephrosis up 15 millimeters justifies a noninvasive postnatal follow-up. Acta Paediatrica. 2008;97:708–713.

    Article  PubMed  Google Scholar 

  9. Broadley P, McHugo J, Morgan I, Whittle MJ, Kilby MD. The 4-year outcome following the demonstration of bilateral renal pelvic dilatation on prenatal renal ultrasound. Br J Radiol. 1999;72:265–270.

    PubMed  CAS  Google Scholar 

  10. Nguyen HT, Herndon CD, Cooper C, Gatti J, Kirsch A, Kokorowski P, et al. The Society for Fetal Urology consensus statement on the evaluation and management of antenatal hydronephrosis. J Pediatr Urol. 2010;6:212–231.

    Article  PubMed  Google Scholar 

  11. Passerotti CC, Kalish LA, Chow J, Passerotti AM, Recabal P, Cendron M, et al. The predictive value of the first postnatal ultrasound in children with antenatal hydronephrosis. J Pediatr Urol. 2011;7:128–136.

    Article  PubMed  Google Scholar 

  12. Ouzounian JG, Castro MA, Fresquez M, al-Sulyman OM, Kovacs BW. Prognostic significance of antenatally detected fetal pyelectasis. Ultrasound Obstet Gynecol. 1996;7:424–428.

    Article  PubMed  CAS  Google Scholar 

  13. Walsh TJ, Hsieh S, Grady R, Mueller BA. Antenatal hydronephrosis and the risk of pyelonephritis hospitalization during the first year of life. Urology. 2007;69:970–974.

    Article  PubMed  Google Scholar 

  14. Indian Pediatric Nephrology Group, Indian Academy of Pediatrics. Consensus statement on management of antenatally detected hydronephrosis. Indian Pediatr. 2001;38:1244–1251.

    Google Scholar 

  15. Psooy K, Pike J. Investigation and management of antenatally detected hydronephrosis. Can Urol Assoc J 2009;3:69–72.

    PubMed  Google Scholar 

  16. Society of Obstetricians and Gynaecologists of Canada. Fetal soft markers in obstetric ultrasound. J Soc Obstet Gynaecol Can. 2005;27:592–612.

    Google Scholar 

  17. Breathnach FM, Fleming A, Malone FD. The second trimester genetic sonogram. Am J Med Genet C Semin Med Genet. 2007;145C:62–72.

    Article  PubMed  Google Scholar 

  18. Pereira AK, Reis ZS, Bouzada MC, de Oliveira EA, Osanan G, Cabral AC. Antenatal ultrasonographic anteroposterior renal pelvis diameter measurement: is it a reliable way of defining fetal hydronephrosis? Obstet Gynecol Int. 2011;2011:861–865.

    Google Scholar 

  19. Chitty LS, Altman DG. Charts of fetal size: kidney and renal pelvis measurements. Prenat Diagn. 2003;23:891–897.

    Article  PubMed  Google Scholar 

  20. Scott JE, Renwick M. Antenatal renal pelvic measurements: what do they mean? Br J Urol Int. 2001;87:376–380.

    Article  CAS  Google Scholar 

  21. Ismaili K, Hall M, Donner C, Thomas D, Vermeylen D, Avni FE; Brussels Free University Perinatal Nephrology study group. Results of systematic screening for minor degrees of fetal renal pelvis dilatation in an unselected population. Am J Obstet Gynecol. 2003;188:242–246.

    Article  PubMed  Google Scholar 

  22. Kim HJ, Jung HJ, Lee HY, Lee YS, Im YJ, Hong CH, et al. Diagnostic value of anteroposterior diameter of fetal renal pelvis during second and third trimesters in predicting postnatal surgery among Korean population: useful information for antenatal counseling. Urology. 2012;79:1132–1137.

    Article  PubMed  Google Scholar 

  23. Corteville JE, Gray DL, Crane JP. Congenital hydronephrosis: correlation of fetal ultrasonographic findings with infant outcome. Am J Obstet Gynecol. 1991;165:384–388.

    PubMed  CAS  Google Scholar 

  24. Scott JE, Wright B, Wilson G, Pearson IA, Matthews JN, Rose PG. Measuring the fetal kidney with ultrasonography. Br J Urol. 1995;76:769–774.

    PubMed  CAS  Google Scholar 

  25. Aksu N, Yava∈can O, Kangin M, Kara OD, Aydin Y, Erdoðan H, et al. Postnatal management of infants with antenatally detected hydronephrosis. Pediatr Nephrol. 2005;20:1253–1259.

    Article  PubMed  Google Scholar 

  26. Sidhu G, Beyene J, Rosenblum ND. Outcome of isolated antenatal hydronephrosis: A systematic review and metaanalysis. Pediatr Nephrol. 2006;21:218–224.

    Article  PubMed  Google Scholar 

  27. Maayan-Metzger A, Lotan D, Jacobson JM, Raviv-Zilka L, Ben-Shlush A, Kuint J, et al. The yield of early postnatal ultrasound scans in neonates with documented antenatal hydronephrosis. Am J Perinatol. 2011;28:613–618.

    Article  PubMed  Google Scholar 

  28. Wollenberg A, Neuhaus TJ, Willi UV, Wisser J. Outcome of fetal renal pelvic dilatation diagnosed during the third trimester. Ultrasound Obstet Gynecol. 2005;25:483–488.

    Article  PubMed  CAS  Google Scholar 

  29. Morin L, Cendron M, Crombleholme TM, Garmel SH, Klauber GT, D’Alton ME. Minimal hydronephrosis in the fetus: clinical significance and implications for management. J Urol. 1996;155:2047–2049.

    Article  PubMed  CAS  Google Scholar 

  30. Thomas DF, Madden NP, Irving HC, Arthur RJ, Smith SE. Mild dilatation of the fetal kidney: a follow-up study. Br J Urol. 1994;74:236–239.

    Article  PubMed  CAS  Google Scholar 

  31. Coplen DE, Austin PF, Yan Y, Blanco VM, Dicke JM. The magnitude of fetal renal pelvic dilatation can identify obstructive postnatal hydronephrosis, and direct postnatal evaluation and management. J Urol. 2006;176:724–727.

    Article  PubMed  Google Scholar 

  32. Feldman DM, DeCambre M, Kong E, Borgida A, Jamil M, McKenna P, et al. Evaluation and follow-up of fetal hydronephrosis. J Ultrasound Med. 2001;20:1065–1069.

    PubMed  CAS  Google Scholar 

  33. Longpre M, Nguan A, Macneily AE, Afshar K. Prediction of the outcome of antenatally diagnosed hydronephrosis: a multivariable analysis. J Pediatr Urol. 2012;8:135–139.

    Article  PubMed  Google Scholar 

  34. Kaefer M, Peters CA, Retik AB, Benacerraf BB. Increased renal echogenicity: a sonographic sign for differentiating between obstructive and nonobstructive etiologies of in utero bladder distension. J Urol. 1997;158:1026–1029.

    Article  PubMed  CAS  Google Scholar 

  35. Lee J, Kimber C, Shekleton P, Cheng W. Prognostic factors of severe foetal megacystis. ANZ J Surg. 2011;81:552–555.

    Article  PubMed  Google Scholar 

  36. Eckholdt F, Heling KS, Woderich R, Wolke S. Posterior urethral valves: prenatal diagnostic signs and outcome. Urol Int. 2004;73:296.

    Article  Google Scholar 

  37. Oliveira EA, Diniz JS, Cabral AC, Pereira AK, Leite HV, Colosimo EA, et al. Predictive factors of fetal urethral obstruction: a multivariate analysis. Fetal Diagn Ther. 2000;15:180.

    Article  PubMed  CAS  Google Scholar 

  38. Robyr R, Benachi A, Daikha-Dahmane F, Martinovich J, Dumez Y, Ville Y. Correlation between ultrasound and anatomical findings in fetuses with lower urinary tract obstruction in the first half of pregnancy. Ultrasound Obstet Gynecol. 2005;25:478–482.

    Article  PubMed  CAS  Google Scholar 

  39. Bernardes LS, Aksnes G, Saada J, Masse V, Elie C, Dumez Y, et al. Keyhole sign: how specific is it for the diagnosis of posterior urethral valves? Ultrasound Obstet Gynecol. 2009;34:419–423.

    Article  PubMed  CAS  Google Scholar 

  40. Babu R, Sai V. Postnatal outcome of fetal hydronephrosis: implications for prenatal counselling. Indian J Urol. 2010;26:60–62.

    Article  PubMed  Google Scholar 

  41. Maizels M, Wang E, Sabbagha RE, Dinsmoor M, Seshadri R, Ginsberg N, et al. Late second trimester assessment of pyelectasis (SERP) to predict pediatric urological outcome is improved by checking additional features. J Matern Fetal Neonatal Med. 2006;19:295–303.

    Article  PubMed  Google Scholar 

  42. Ghidini A, Strobelt N, Lynch L, Berkowitz RL. Fetal urinoma: a case report and review of its clinical significance. J Ultrasound Med. 1994;13:989–991.

    PubMed  CAS  Google Scholar 

  43. Miller M, Korzets Ze, Blumenfeld Y, Pomeranz M, Aviram R, Rathaus V, et al. Fetal urinoma as a sign of a dysplastic kidney. Pediatr Nephrol. 2003;18:65–67.

    Article  PubMed  Google Scholar 

  44. Oktar T, Acar O, Atar A, Salabas E, Ander H, Ziylan O, et al. How does the presence of antenatally detected caliectasis predict the risk of postnatal surgical intervention? Urology. 2012;80:203–206.

    Article  PubMed  Google Scholar 

  45. Oliveira EA, Diniz JS, Cabral AC, Leite HV, Colosimo EA, Oliveira RB, et al. Prognostic factors in fetal hydronephrosis: a multivariate analysis. Pediatr Nephrol. 1999;13:859–864

    Article  PubMed  CAS  Google Scholar 

  46. Oliveira EA, Rabelo EAS, Pereira AK, Diniz JS, Cabral ACV, Leite HV, et al. Prognostic factors in prenatallydetected posterior urethral valves: a multivariate analysis. Pediatr Surg Int. 2002;18:662–667.

    PubMed  Google Scholar 

  47. Zaccara A, Giorlandino C, Mobili L, Brizzi C, Bilancioni E, Capolupo I, et al. Amniotic fluid index and fetal bladder outlet obstruction. Do we really need more? J Urol. 2005;174:1657–1660.

    Article  PubMed  Google Scholar 

  48. Sibai H, Salle JL, Houle AM, Lambert R. Hydronephrosis with diffuse or segmental cortical thinning: impact on renal function. J Urol. 2001;165:2293–2295.

    Article  PubMed  CAS  Google Scholar 

  49. Daikha-Dahmane F, Dommergues M, Muller F, Narcy F, Lacoste M, Beziau A, et al. Development of human fetal kidney in obstructive uropathy: correlations with ultrasonography and urine biochemistry. Kidney Int. 1997;52:21–32.

    Article  PubMed  CAS  Google Scholar 

  50. Mahony BS, Filly RA, Callen PW, Hricak H, Golbus MS, Harrison MR. Fetal renal dysplasia: sonographic evaluation. Radiology. 1984;152:143–146.

    PubMed  CAS  Google Scholar 

  51. Mashiach R, Davidovits M, Eisenstein B, Kidron D, Kovo M, Shalev J, et al. Fetal hyperechogenic kidney with normal amniotic fluid volume: a diagnostic dilemma. Prenat Diagn. 2005;25:553–558.

    Article  PubMed  CAS  Google Scholar 

  52. Estroff JA, Mandell J, Benacerraf BR. Increased renal parenchymal echogenicity in the fetus: importance and clinical outcome. Radiology. 1991;181:135–159.

    PubMed  CAS  Google Scholar 

  53. Bromley B, Lieberman E, Shipp TD, Benacerraf BR. The genetic sonogram: a method of risk assessment for Down syndrome in the second trimester. J Ultrasound Med. 2002;21:1087.

    PubMed  Google Scholar 

  54. American College of Obstetrics and Gynaecology. Invasive prenatal testing for aneuploidy.ACOG Practice Bulletin Clinical management guidelines for Obstetrician-gynecologists. 2007;88:1459–1467.

    Google Scholar 

  55. Havutcu AE, Nikolopoulos G, Adinkra P, Lamont RF. The association between fetal pyelectasis on second trimester ultrasound scan and aneuploidy among 25,586 low risk unselected women. Prenat Diagn. 2002;22:1201–1206.

    Article  PubMed  CAS  Google Scholar 

  56. Coco C, Jeanty P. Isolated fetal pyelectasis and chromosomal abnormalities. Am J Obstet Gynecol. 2005;193:732–738.

    Article  PubMed  Google Scholar 

  57. Smith-Bindman R, Hosmer W, Feldstein VA, Deeks JJ, Goldberg JD. Second-trimester ultrasound to detect fetuses with Down syndrome: a meta-analysis. JAMA. 2001;285:1044–1055.

    Article  PubMed  CAS  Google Scholar 

  58. Wladimiroff JW, Sachs ES, Reuss A, Stewart PA, Pijpers L, Niermeijer MF. Prenatal diagnosis of chromosome abnormalities in the presence of fetal structural defects. Am J Med Genet. 1988;29:289–291.

    Article  PubMed  CAS  Google Scholar 

  59. Staebler M, Donner C, Van Regemorter N, Duprez L, De Maertelaer V, Devreker F, et al. Should determination of the karyotype be systematic for all malformations detected by obstetrical ultrasound? Prenat Diagn. 2005;25:567–573.

    Article  PubMed  CAS  Google Scholar 

  60. Bobrowski RA, Levin RB, Lauria MR, Treadwell MC, Gonik B, Bottoms SF. In utero progression of isolated renal pelvis dilation. Am J Perinatol. 1997;14:423–426.

    Article  PubMed  CAS  Google Scholar 

  61. Signorelli M, Cerri V, Taddei F, Groli C, Bianchi UA. Prenatal diagnosis and management of mild fetal pyelectasis: implications for neonatal outcome and followup. Eur J Obstet Gynecol Reprod Biol. 2005;118:154–159.

    Article  PubMed  Google Scholar 

  62. Siemens DR, Prouse KA, MacNeily AE, Sauerbrei EE. Antenatal hydronephrosis: thresholds of renal pelvic diameter to predict insignificant postnatal pelviectasis. Tech Urol. 1998;4:198–201.

    PubMed  CAS  Google Scholar 

  63. Alconcher LF, Tombesi MM. Natural history of bilateral mild isolated antenatal hydronephrosis conservatively managed. Pediatr Nephrol. 2012;27:1119–1123.

    Article  PubMed  Google Scholar 

  64. Wilkins IA, Chitkara U, Lynch L, Goldberg JD, Mehalek KE, Berkowitz RL. The non-predictive value of fetal urinary electrolytes: Preliminary report of outcomes and correlations with pathologic diagnosis. Am J Obstet Gynecol. 1987;157:694–698.

    PubMed  CAS  Google Scholar 

  65. Crombleholme TM, Harrison MR, Golbus MS, Longaker MT, Langer JC, Callen PW, et al. Fetal intervention in obstructive uropathy: Prognostic indicators and efficacy of intervention. Am J Obstet Gynecol. 1990;162:1239–1244.

    PubMed  CAS  Google Scholar 

  66. Morris RK, Ruano R, Kilby MD. Effectiveness of fetal cystoscopy as a diagnostic and therapeutic intervention for lower urinary tract obstruction: a systematic review. Ultrasound Obstet Gynecol. 2011;37:629–637.

    Article  PubMed  CAS  Google Scholar 

  67. Spitzer A. The current approach to the assessment of fetal renal function: fact or fiction? Pediatr Nephrol. 1996;10:230–235.

    Article  PubMed  CAS  Google Scholar 

  68. Holmes N, Harrison MR, Baskin LS. Fetal surgery for posterior urethral valves: long-term postnatal outcomes. Pediatrics. 2001;108:E7.

    Article  PubMed  CAS  Google Scholar 

  69. Ruano R, Duarte S, Bunduki V, Giron AM, Srougi M, Zugaib M. Fetal cystoscopy for severe lower urinary tract obstruction — initial experience of a single center. Prenat Diagn. 2010;30:30–39.

    PubMed  Google Scholar 

  70. Clark TJ, Martin WL, Divakaran TG, Whittle MJ, Kilby MD, Khan KS. Prenatal bladder drainage in the management of fetal lower urinary tract obstruction: a systematic review and meta-analysis. Obstet Gynecol. 2003;102:367–382.

    Article  PubMed  Google Scholar 

  71. Morris RK, Malin GL, Khan KS, Kilby MD. Systematic review of the effectiveness of antenatal intervention for the treatment of congenital lower urinary tract obstruction. BJOG. 2010;117:382–390.

    Article  PubMed  CAS  Google Scholar 

  72. McLorie G, Farhat W, Khoury A, Geary D, Ryan G. Outcome analysis of vesicoamniotic shunting in a comprehensive population. J Urol. 2001;166:1036–1040.

    Article  PubMed  CAS  Google Scholar 

  73. Biard JM, Johnson MP, Carr MC, Wilson RD, Hedrick HL, Pavlock C, et al. Long-term outcomes in children treated by prenatal vesicoamniotic shunting for lower urinary tract obstruction. Obstet Gynecol. 2005;106:503–508.

    Article  PubMed  Google Scholar 

  74. Pluto Collaborative Study Group, Kilby M, Khan K, Morris K, Daniels J, Gray R, Magill L, et al. PLUTO trial protocol: percutaneous shunting for lower urinary tract obstruction randomised controlled trial. BJOG. 2007;114,904–905.

    Article  PubMed  Google Scholar 

  75. Masson P, De Luca G, Tapia N, Le Pommelet C, Sathi A, Touati K, et al. Postnatal investigation and outcome of isolated fetal renal pelvis dilatation. Archives de Pe?diatrie. 2009;16:1103–1110.

    Article  CAS  Google Scholar 

  76. Ismaili M, Avni FE, Wissing KM, Hall M; Brussels Free University Perinatal Nephrology Study Group. Long term clinical outcome of infants with mild and moderate fetal pyelectasis: validation of neonatal ultrasound as a screening tool to detect significant nephrouropathies. J Pediatr. 2004;144:759–765.

    PubMed  Google Scholar 

  77. Moorthy I, Joshi N, Cook JV, Warren M. Antenatal hydronephrosis: negative predictive value of normal postnatal ultrasound: a 5-year study. Clin Radiol. 2003;58:964–970.

    Article  PubMed  CAS  Google Scholar 

  78. Nepple KG, Arlen AM, Austin JC, Cooper CS. The prognostic impact of an abnormal initial renal ultrasound on early reflux resolution. J Pediatr Urol. 2011;7:462–466.

    Article  PubMed  Google Scholar 

  79. Dejter SW Jr, Gibbons MD. The fate of infant kidneys with fetal hydronephrosis but initially normal postnatal sonography. J Urol. 1989;142:661–662.

    PubMed  Google Scholar 

  80. Wiener JS, O’Hara SM. Optimal timing of initial postnatal ultrasonography in newborns with prenatal hydronephrosis. J Urol. 2002;168:1826–1829.

    Article  PubMed  Google Scholar 

  81. Cordero L, Nankervis CA, Oshaughnessy RW, Koff SA, Giannone PJ. Postnatal follow-up of antenatal hydronephrosis: a health-care challenge. J Perinatol. 2009;29:382–387.

    Article  PubMed  CAS  Google Scholar 

  82. Homsy YL, Saad F, Laberge I, Williot P, Pison C. Transitional hydronephrosis of the newborn and infant. J Urol. 1990;144:579–583.

    PubMed  CAS  Google Scholar 

  83. Grignon A, Filion R, Filiatrault D, Robitaille P, Homsy Y, Boutin H, et al. Urinary tract dilatation in utero: classification and clinical applications. Radiology. 1986;160:645–647.

    PubMed  CAS  Google Scholar 

  84. Fernbach SK, Maizels M, Conway JJ. Ultrasound grading of hydronephrosis: Introduction to the system used by the Society for Fetal Urology. Pediatr Radiol. 1993;23:478–480.

    Article  PubMed  CAS  Google Scholar 

  85. Siemens DR, Prouse KA, MacNeily AE, Sauerbrei EE. Antenatal hydronephrosis: thresholds of renal pelvic diameter to predict insignificant postnatal pelviectasis. Tech Urol. 1998;4:198–201.

    PubMed  CAS  Google Scholar 

  86. Anderson NG, Fischer J, Leighton D, Hector-Taylor J, McEwing RL. Management in children of mild postnatal renal dilatation but without vesicoureteral reflux. Pediatr Nephrol. 2010;25:477–483.

    Article  PubMed  Google Scholar 

  87. Toiviainen-Salo S, Garel L, Grignon A, Dubois J, Rypens F, Boisvert J, et al. Fetal hydronephrosis: is there hope for consensus? Pediatr Radiol 2004;34:519–529.

    Article  PubMed  Google Scholar 

  88. Dremsek PA, Gindl K, Voitl P, Strobl R, Hafner E, Geissler W, et al. Renal pyelectasis in fetuses and neonates: diagnostic value of renal pelvis diameter in preand postnatal sonographic screening. Am J Roentgenol. 1997;168:1017–1019.

    Article  CAS  Google Scholar 

  89. Clautice-Engle T, Anderson NG, Allan RB, Abbott GD. Diagnosis of obstructive hydronephrosis in infants: comparison sonograms performed 6 days and 6 weeks after birth. AJR Am J Roentgenol. 1995;164:963–967.

    Article  PubMed  CAS  Google Scholar 

  90. Alconcher L, Tombesi M. Mild antenatal hydronephrosis: management controversies. Pediatr Nephrol. 2004; 19:819–820.

    Article  PubMed  Google Scholar 

  91. Chertin B, Pollack A, Koulikov D, Rabinowitz R, Hain D, Hadas-Halpren I, et al. Conservative treatment of ureteropelvic junction obstruction in children with antenatal diagnosis of hydronephrosis: lessons learned after 16 years of follow-up. Eur Urol. 2006;49:734–738.

    Article  PubMed  Google Scholar 

  92. Mercado-Deane MG, Beeson JE, John SD. US of renal insufficiency in neonates. Radiographics. 2002;22: 1429–1438.

    Article  PubMed  Google Scholar 

  93. Kaefer M, Barnewolt C, Retik AB, Peters CA. The sonographic diagnosis of infravesical obstruction in children: evaluation of bladder wall thickness indexed to bladder filling. J Urol. 1997;157:989–991.

    Article  PubMed  CAS  Google Scholar 

  94. Tibballs JM, De Bruyn R. Primary vesicoureteric reflux- How useful is postnatal ultrasound? Arch Dis Child. 1996;75:444–447.

    Article  PubMed  CAS  Google Scholar 

  95. Sarhan OM, El-Ghoneimi AA, Helmy TE, Dawaba MS, Ghali AM, Ibrahiem el-HI. Posterior urethral valves: multivariate analysis of factors affecting the final renal outcome. J Urol. 2011;185:2491–2495.

    Article  PubMed  Google Scholar 

  96. Chavhan G, Daneman A, Moineddin R, Lim R, Langlois V, Traubici J. Renal pyramid echogenicity in ureteropelvic junction obstruction: correlation between altered echogenicity and differential renal function. Pediatr Radiol. 2008;38:1068–1073.

    Article  PubMed  Google Scholar 

  97. Chi T, Feldstein VA, Nguyen HT. Increased echogenicity as a predictor of poor renal function in children with grade 3 to 4 hydronephrosis. J Urol. 2006;175:1898–1901.

    Article  PubMed  Google Scholar 

  98. Sanders RC, Nussbaum AR, Solez K. Renal dysplasia: sonographic findings. Radiology. 1988; 167: 623–626.

    PubMed  CAS  Google Scholar 

  99. Lidefelt KJ, Herthelius M. Antenatal hydronephrosis: infants with minor postnatal dilatation do not need prophylaxis. Pediatr Nephrol. 2008;23:2021–2024.

    Article  PubMed  Google Scholar 

  100. Shukla AR, Cooper J, Patel RP, Carr MC, Canning DA, Zderic SA, et al. Prenatally detected primary megaureter: a role for extended followup. J Urol. 2005;173:1353–1356.

    Article  PubMed  Google Scholar 

  101. Matsui F, Shimada K, Matsumoto F, Takano S. Late recurrence of symptomatic hydronephrosis in patients with prenatally detected hydronephrosis and spontaneous improvement. J Urol. 2008;180:322–325.

    Article  PubMed  Google Scholar 

  102. Gatti JM, Broecker BH, Scherz HC, Perez-Brayfield MR, Kirsch AJ. Antenatal hydronephrosis with postnatal resolution: how long are postnatal studies warranted? Urology. 2001;57:1178.

    Article  CAS  Google Scholar 

  103. Hafez AT, McLorie G, Bagli D, Khoury A. Analysis of trends on serial ultrasound for high grade neonatal hydronephrosis. J Urol. 2002;168:1518–1521.

    Article  PubMed  Google Scholar 

  104. Szymanski KM, Al-Said AN, Pippi Salle JL, Capolicchio JP. Do infants with mild prenatal hydronephrosis benefit from screening for vesicoureteral reflux? J Urol. 2012;188:576–581.

    Article  PubMed  Google Scholar 

  105. Peters CA, Skoog SJ, Arant BS Jr, Copp HL, Elder JS, Hudson RG, et al. Summary of the AUA Guideline on management of primary vesicoureteral reflux in children. J Urol. 2010;184:1134–1144.

    Article  PubMed  Google Scholar 

  106. Lee RS, Diamond DA, Chow JS. Applying the ALARA concept to the evaluation of vesicoureteric reflux. Pediatr Radiol. 2006;36:185–191.

    Article  PubMed  Google Scholar 

  107. Coelho GM, Bouzada MC, Pereira AK, Figueiredo BF, Leite MR, Oliveira DS, et al. Outcome of isolated antenatal hydronephrosis. A prospective cohort study. Pediatr Nephrol 2007;22:1727–1734.

    Article  Google Scholar 

  108. Tombesi MM, Alconcher LF. Short-term outcome of mild isolated antenatal hydronephrosis conservatively managed. J Pediatr Urol. 2012;8:129–133.

    Article  PubMed  Google Scholar 

  109. Hothi DK, Wade AS, Gilbert R, Winyard PJD. Mild fetal pelvis dilatation-Much ado about nothing? Clin J Am Soc Nephrol 2009;4:168–177

    Article  PubMed  Google Scholar 

  110. Riccabona M, Avni FE, Blickman JG, Dacher JN, Darge K, Lobo ML, et al. Imaging recommendations in paediatric uroradiology: minutes of the ESPR workgroup session on urinary tract infection, fetal hydronephrosis, urinary tract ultrasonography and voiding cystourethrography, Barcelona, Spain, June 2007. Pediatr Radiol. 2008; 38:138–145.

    Article  PubMed  Google Scholar 

  111. Zerin JM, Ritchey ML, Chang AC. Incidental vesicoureteral reflux in neonates with antenatally detected hydronephrosis and other renal abnormalities. Radiology. 1993;187:157–160.

    PubMed  CAS  Google Scholar 

  112. Hodson EM, Wheeler DM, Vimalchandra D, Smith GH, Craig JC. Interventions for primary vesicoureteric reflux. Cochrane Database Syst Rev. 2007;18:CD001532.

    Google Scholar 

  113. Garin EH, Olavarria F, Garcia Nieto V, Valenciano B, Campos A, Young L. Clinical significance of primary vesicoureteral reflux and urinary antibiotic prophylaxis after acute pyelonephritis: a multicenter, randomized, controlled study. Pediatrics. 2006;117:626–632.

    Article  PubMed  Google Scholar 

  114. Phan V, Traubici J, Hershenfield B, Stephens D, Rosenblum ND, Geary DF. Vesicoureteral reflux in infants with isolated antenatal hydronephrosis. Pediatr Nephrol. 2003;18:1224–1228.

    Article  PubMed  Google Scholar 

  115. Blane CE, DiPietro MA, Zerin JM, Sedman AB, Bloom DA. Renal sonography is not a reliable screening examination for vesicoureteral reflux. J Urol. 1993;150:752–755.

    PubMed  CAS  Google Scholar 

  116. Tibballs JM, De Bruyn R. Primary vesicoureteric reflux- How useful is postnatal ultrasound? Arch Dis Child. 1996;75:444–447.

    Article  PubMed  CAS  Google Scholar 

  117. Grazioli S, Parvex P, Merlini L, Combescure C, Girardin E. Antenatal and postnatal ultrasound in the evaluation of the risk of vesicoureteral reflux. Pediatr Nephrol. 2010;25:1687–1692.

    Article  PubMed  Google Scholar 

  118. Lidefelt KJ, Herthelius M. Antenatal hydronephrosis: infants with minor postnatal diaxislatation do not need prophylaxis. Pediatr Nephrol, 2008;23:2021–2024

    Article  PubMed  Google Scholar 

  119. Abdulnour HA, Williams JL, Kairalla JA, Garin EH. Does hydronephrosis predict the presence of severe vesicoureteral reflux? Eur J Pediatr. 2012;171:1605–1610.

    Article  PubMed  Google Scholar 

  120. Finnell SM, Carroll AE, Downs SM; Subcommittee on Urinary Tract Infection. Technical report-Diagnosis and management of an initial UTI in febrile infants and young children. Pediatrics. 2011;128:e749–770.

    Article  PubMed  Google Scholar 

  121. Ismaili K, Avni FE, Hall M. Results of systematic voiding cystourethrography in infants with antenatally diagnosed renal pelvis dilatation. J Pediatr. 2002;141:21–24.

    Article  PubMed  Google Scholar 

  122. Ward VL. Patient dose reduction during voiding cystourethrography. Pediatr Radiol. 2006;36:168–172.

    Article  PubMed  Google Scholar 

  123. Hubertus J, Plieninger S, Martinovic V, Heinrich M, Schuster T, Bürst M, et al. Children and adolescents with ureteropelvic junction obstruction: is an additional voiding cystourethrogram necessary? Results of a multicenter study. World J Urol. 2012; DOI 10.1007/s00345-012-0918-x

    Google Scholar 

  124. Gordon I, Piepsz A, Sixt R. Guidelines for standard and diuretic renogram in children. Eur J Nucl Med Mol Imaging. 2011;38:1175–1188.

    Article  PubMed  Google Scholar 

  125. Itoh K. 99mTc-MAG3: review of pharmacokinetics, clinical application to renal diseases and quantification of renal function. Ann Nucl Med. 2001;15:179–190.

    Article  PubMed  CAS  Google Scholar 

  126. Atasever T, Ozkaya O, Abamor E, Söylemezoglu O, Buyan N, Unlü M. 99mTc ethylene dicysteine scintigraphy for diagnosing cortical defects in acute pyelonephritis: a comparative study with 99mTc dimercaptosuccinic acid. Nucl Med Commun. 2004;25:967–970.

    Article  PubMed  Google Scholar 

  127. Lassmann M, Biassoni L, Monsieurs M, Franzius C, Jacobs F, EANM Dosimetry and Paediatrics Committees. The new EANM paediatric dosage card. Eur J Nucl Med Mol Imaging. 2008;35:1748.

    Article  PubMed  CAS  Google Scholar 

  128. Donoso G, Kuyvenhoven JD, Ham H, Piepsz A. 99mTc-MAG3 diuretic renography in children: a comparison between F0 and F+20. Nucl Med Commun. 2003;24:1189–1193.

    Article  PubMed  CAS  Google Scholar 

  129. Conway JJ, Maizels M. The “well tempered” diuretic renogram: a standard method to examine the asymptomatic neonate with hydronephrosis or hydroureteronephrosis. A report from combined meetings of the Society for Fetal Urology and members of the Pediatric Nuclear Medicine Council-the Society of Nuclear Medicine. J Nucl Med. 1992;33:2047–2051.

    PubMed  CAS  Google Scholar 

  130. Piepz A. Antenatal detection of pelviureteric junction stenosis: main controversies. Semin Nucl Med. 2011;41:11–19.

    Article  Google Scholar 

  131. Prigent A, Cosgriff P, Gates GF, Granderus G, Fine EJ, Itoh K, et al. Consensus report on quality control of quantitative measurements of renal function obtained from renogram: International Consensus Committee from the Scientific Committee of Radionuclides in Nephrourology. Semin Nucl Med. 1999;29:146–159.

    Article  PubMed  CAS  Google Scholar 

  132. Eskild-Jensen A, Gordon I, Piepsz A, Frøkiaer J. Interpretation of the renogram: problems and pitfalls in hydronephrosis in children. BJU Int. 2004;94:887–892.

    Article  PubMed  Google Scholar 

  133. Josephson S. Antenatally detected, unilateral dilatation of the renal pelvis: a critical review. 1. Postnatal nonoperative treatment 20 years on-is it safe? Scand J Urol Nephrol. 2002;36:243–250.

    Article  PubMed  CAS  Google Scholar 

  134. Moon DH, Park YS, Jun NL, Lee SY, Kim KS, Kim JH, et al. Value of supranormal function and renogram patterns on 99mTc-mercaptoacetyltriglycine scintigraphy in relation to the extent of hydronephrosis for predicting ureteropelvic junction obstruction in the newborn. J Nucl Med. 2003;44:725–731.

    PubMed  Google Scholar 

  135. Oh SJ, Moon DH, Kang W, Park YS, Park T, Kim KS. Supranormal differential renal function is real but may be pathological: assessment by 99m technetium mercaptoacetyltriglycine renal scan of congenital unilateral hydronephrosis. J Urol. 2001;165:2300–2304.

    Article  PubMed  CAS  Google Scholar 

  136. Amarante J, Anderson PJ, Gordon I. Impaired drainage on diuretic renography using half-time or pelvic excretion efficiency is not a sign of obstruction in children with a prenatal diagnosis of unilateral renal pelvic dilatation. J Urol. 2003;169:1828–1831.

    Article  PubMed  CAS  Google Scholar 

  137. Yohannes P, Hanna M. Current trends in the management of posterior urethral valves in the pediatric population. Urology. 2002; 60:947–953.

    Article  PubMed  Google Scholar 

  138. Sarhan O, Zaccaria I, Macher MA, Muller F, Vuillard E, Delezoide AL, et al. Long-term outcome of prenatally detected posterior urethral valves: single center study of 65 cases managed by primary valve ablation. J Urol. 2008;179:307–312.

    Article  PubMed  Google Scholar 

  139. Bajpai M, Dave S, Gupta DK. Factors affecting outcome in the management of posterior urethral valves. Pediatr Surg Int. 2001;17:11–15

    Article  PubMed  CAS  Google Scholar 

  140. Salem YH, Majd M, Rushton HG, Belman AB. Outcome analysis of pediatric pyeloplasty as a function of patient age, presentation and differential renal function. J Urol. 1995; 154:1889–1893.

    Article  PubMed  CAS  Google Scholar 

  141. Madden NP, Thomas DF, Gordon AC, Arthur RJ, Irving HC, Smith SE. Antenatally detected pelviureteric junction obstruction. Is non-operation safe? Br J Urol. 1993;68:305–310.

    Article  Google Scholar 

  142. Thomas DF. Prenatal diagnosis: what do we know of long-term outcomes? J Pediatr Urol. 2010;6:204–211.

    Article  PubMed  CAS  Google Scholar 

  143. Bajpai M, Bal CS, Kalaivani M, Gupta AK. Plasma renin activity for monitoring vesicoureteric reflux therapy: mid-term observations. J Pediatr Urol. 2008; 4:60–64

    Article  PubMed  Google Scholar 

  144. Heinlen JE, Manatt CS, Bright BC, Kropp BP, Campbell JB, Frimberger D. Operative versus nonoperative management of ureteropelvic junction obstruction in children. Urology. 2009;73:521–525.

    Article  PubMed  Google Scholar 

  145. Ransley PG, Dhillon HK, Gordon I, Duffy PG, Dillon MJ, Barratt TM. The postnatal management of hydronephrosis diagnosed by prenatal ultrasound. J Urol. 1990;144:584–587.

    PubMed  CAS  Google Scholar 

  146. Heinlen JE, Kropp BP, Frimberger DC. Progression of hydronephrosis correlates with worsening renal function in children. Conference: 2009 American Urological Association (AUA) Annual Meeting Chicago, IL United States. Conference Publication. J Urol. 2009;181:443.

    Article  Google Scholar 

  147. Zampieri N, Zamboni C, Ottolenghi A, Camoglio FS. Unilateral hydronephrosis due to ureteropelvic junction obstruction in children: long term follow-up. Minerva Urol Nefrol. 2009;61:325–329.

    PubMed  CAS  Google Scholar 

  148. Chertin B, Rolle U, Farkas A, Puri P. Does delaying pyeloplasty affect renal function in children with a prenatal diagnosis of pelvi-ureteric junction obstruction? BJU Int. 2002;90:72–75.

    Article  PubMed  CAS  Google Scholar 

  149. Uluocak N, Ander H, Acar O, Amasyali AS, Erkorkmaz U, Ziylan O. Clinical and radiological characteristics of patients operated in the first year of life due to ureteropelvic junction obstruction: significance of renal pelvis diameter. Urology. 2009;74:898–902.

    Article  PubMed  Google Scholar 

  150. Kumar S, Walia S, Ikpeme O, Zhang E, Paramasivam G, Agarwal S, et al. Postnatal outcome of prenatally diagnosed severe fetal renal pelvic dilatation. Prenat Diagn. 2012;32:519–522.

    Article  PubMed  Google Scholar 

  151. Dhillon HK. Prenatally diagnosed hydronephrosis: the Great Ormond Street experience. Br J Urol. 1998;81:39–44.

    Article  PubMed  Google Scholar 

  152. Koff SA, Campbell KD. The nonoperative management of unilateral neonatal hydronephrosis: natural history of poorly functioning kidneys. J Urol. 1994;152:593–595.

    PubMed  CAS  Google Scholar 

  153. Kim YS, Cho CK, Han SW. Comparison between unilateral pyeloplasty and conservative treatment in bilateral ureteropelvic junction obstruction of children. Korean J Urol. 1998;39:1248–1253.

    Google Scholar 

  154. Onen A, Jayanthi VR, Koff SA. Long-term follow up of prenatally detected severe bilateral newborn hydronephrosis initially managed nonoperatively. J Urol. 2002;168:1118–1120.

    Article  PubMed  CAS  Google Scholar 

  155. Kim J, Hong S, Park CH, Park H, Kim KS. Management of severe bilateral ureteropelvic junction obstruction in neonates with prenatally diagnosed bilateral hydronephrosis. Korean J Urol. 2010;51:653–656.

    Article  PubMed  Google Scholar 

  156. Bajpai M, Chandrasekharam VV. Nonoperative management of neonatal moderate to severe bilateral hydronephrosis. J Urol. 2002;167:662–665

    Article  PubMed  Google Scholar 

  157. Estrada CR, Peters CA, Retik AB, Nguyen HT. Vesicoureteral reflux and urinary tract infection in children with a history of prenatal hydronephrosis- should voiding cystourethrography be performed in cases of postnatally persistent grade II hydronephrosis? J Urol. 2009;181:801–806.

    Article  PubMed  Google Scholar 

  158. Kapadia H, Lidefelt KJ, Erasmie U, Pilo C. Antenatal renal pelvis dilatation emphasizing vesicoureteric reflux: two year follow-up of minor postnatal dilatation. Acta Paediatr. 2004;93:336–339.

    Article  PubMed  CAS  Google Scholar 

  159. Lee JH, Choi HS, Kim JK, Won HS, Kim KS, Moon DH, et al. Nonrefluxing neonatal hydronephrosis and the risk of urinary tract infection. J Urol. 2008;179:1524–1528.

    Article  PubMed  Google Scholar 

  160. Song SH, Lee SB, Park YS, Kim KS. Is antibiotic prophylaxis necessary in infants with obstructive hydronephrosis? J Urol 2007;177:1098–1101.

    Article  PubMed  Google Scholar 

  161. Yavascan O, Aksu N, Anil M, Kara OD, Aydin Y, Kangin M, et al. Postnatal assessment of growth, nutrition, and urinary tract infections of infants with antenatally detected hydronephrosis. Int Urol Nephrol. 2010; 48:781–788.

    Article  Google Scholar 

  162. Mori R, Fitzgerald A, Williams C, Tullus K, Verrier-Jones K, Lakhanpaul M. Antibiotic prophylaxis for children at risk of developing urinary tract infection: a systematic review. Acta Paediatr. 2009;98:1781–1786.

    Article  PubMed  Google Scholar 

  163. Mattoo TK. Evidence for and against urinary prophylaxis in vesicoureteral reflux. Pediatr Nephrol. 2010;25:2379–2382.

    Article  PubMed  Google Scholar 

  164. Skoog SJ. Prophylaxis versus no prophylaxis for reflux. J Urol. 2012;187:1161–1162.

    Article  PubMed  Google Scholar 

  165. Indian Society of Pediatric Nephrology, Vijayakumar M, Kanitkar M, Nammalwar BR, Bagga A. Revised statement on management of urinary tract infections. Indian Pediatr. 2011;48:709–717.

    PubMed  CAS  Google Scholar 

  166. Peters CA, Skoog SJ, Arant BS Jr, Copp HL, Elder JS, Hudson RG, et al. Summary of the AUA Guideline on Management of Primary Vesicoureteral Reflux in Children. J Urol. 2010; 184:1134–1144.

    Article  PubMed  Google Scholar 

  167. Cascio S, Chertin B, Colhoun E, Puri P. Renal parenchymal damage in male infants with high grade vesicoureteral reflux diagnosed after the first urinary tract infection. J Urol. 2002;168:1708–1710.

    Article  PubMed  CAS  Google Scholar 

  168. Ismaili K, Avni FE, Piepsz A, Wissing KM, Cochat P, Aubert D, et al. Current management of infants with fetal renal pelvis dilation: a survey by French-speaking pediatric nephrologists and urologists. Pediatr Nephrol. 2004;19:966–971.

    Article  PubMed  Google Scholar 

  169. Islek A, Güven AG, Koyun M, Akman S, Alimoglu E. Probability of urinary tract infection in infants with ureteropelvic junction obstruction: is antibacterial prophylaxis really needed? Pediatr Nephrol. 2011;26:1837–1841.

    Article  PubMed  Google Scholar 

  170. Roth CC, Hubanks JM, Bright BC, Heinlen JE, Donovan BO, Kropp BP, et al. Occurrence of urinary tract infection in children with significant upper urinary tract obstruction. Urology. 2009;73:74–78.

    Article  PubMed  Google Scholar 

  171. Madden NP, Thomas DF, Gordon AC, Arthur RJ, Irving HC, Smith SE. Antenatally detected pelviureteric junction obstruction. Is non-operation safe? Br J Urol. 1993;68:305–310.

    Article  Google Scholar 

  172. Brenner DJ, Hall EJ. Computed tomography-An increasing source of radiation exposure. N Engl J Med 2007;357:2277–2284

    Article  PubMed  CAS  Google Scholar 

  173. Mettler FA, Jr, Huda W, Yoshizumi TT, Mahesh M. Effective doses in radiology and diagnostic nuclear medicine: A catalog. Radiology. 2008;248:254–263.

    Article  PubMed  Google Scholar 

  174. Smith T, Gordon I. An update of radiopharmaceutical schedules in children. Nucl Med Communicat 1998;19:1023–1036

    Article  CAS  Google Scholar 

  175. Pearce MS, Salotti JA, Little MP, McHugh K, Lee C, Kim KP, et al. Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study. Lancet. 2012;380:499–505

    Article  PubMed  Google Scholar 

  176. Stabin MG, Gelfand MJ. Dosimetry of pediatric nuclear medicine procedures. Q J Nucl Med. 1998;42:93–112.

    PubMed  CAS  Google Scholar 

  177. Fahey FH, Treves ST, Adelstein SJ. Minimizing and communicating radiation risk in pediatric nuclear medicine J Nucl Med Technol. 2012;40:13–24.

    Article  PubMed  Google Scholar 

  178. Smith T, Gordon I. An update of radiopharmaceutical schedules in children. Nucl Med Commun. 1998;19:1023–1036.

    Article  PubMed  CAS  Google Scholar 

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Sinha, A., Bagga, A., Krishna, A. et al. Revised guidelines on management of antenatal hydronephrosis. Indian Pediatr 50, 215–231 (2013). https://doi.org/10.1007/s13312-013-0064-6

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